Microglia at a key inflection point in Alzheimer’s disease

作者: 未知作者

摘要 / Abstract

We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amyloid plaques and tau pathology that distinguish early, clinically silent, disease from later stages associated with cognitive decline.

同行评议区

登录学者账户后即可在此处发表评述或点赞。

立即登录

暂无评议记录。