探索全球前沿学术脉络

01.

medRxiv (Medicine) 2026-06-16 DOI: HASH:0d740f4dc207d41880b8e76bfbe736d7

High-Risk Anti-Seizure Medication Use in Childbearing-Age People with Epilepsy in a Taenia solium Endemic Region

作者:

Allen↗S. E↗Wardle↗M. T↗Moyano↗L. M↗Vilchez↗Bustos↗J. A↗Garcia↗H. H↗O'Neal↗…

Background: People of childbearing potential with epilepsy in regions endemic for Taenia solium, where neurocysticercosis (NCC) is highly prevalent, represent a vulnerable population due to the elevated burden of epilepsy and resource limitations. Clinical practice in these settings remains poorly characterized. This study characterized anti-seizure medication (ASM) prescribing patterns by medication risk profiles among people of childbearing potential with epilepsy in Northern Peru, a region highly endemic for T. solium. Methods: Participants were drawn from a prospective, population-based epilepsy cohort in Tumbes, Peru (2006 to 2020). The analytic population included females with epilepsy aged 15 to 49 years. The primary outcome was pregnancy-associated ASM risk of congenital malformations and adverse neurodevelopmental outcomes. ASMs were classified as ''Established Low Risk'' (lamotrigine, levetiracetam), ''Possible Risk/Inadequate Data'' (carbamazepine, phenobarbital, phenytoin), and ''Established High Risk'' (valproic acid). Prescription patterns were examined in relation to demographic and clinical characteristics. Results: Among 1,975 individuals with epilepsy, 685 were people of childbearing potential. Approximately 34.9% met criteria for probable or definite NCC. Most ASM prescriptions were in the ''Possible Risk/Inadequate Data'' category (87.0%), and 12.8% received ''Established High Risk'' medications. In multivariable analysis, high-risk prescribing was associated with prior ASM use and polytherapy. Discussion: People of childbearing potential with epilepsy were predominantly treated with carbamazepine, phenytoin, phenobarbital, and valproate, reflecting local ASM availability. Despite evidence supporting lamotrigine and levetiracetam in pregnancy, prescribing patterns reflect local formulary constraints. These findings highlight a gap between guideline recommendations and real-world prescribing in resource-limited settings, underscoring the need for context-specific treatment strategies.

阅读与讨论 → 访问原文 →

02.

arXiv (CS.CL) 2026-06-16 DOI: arXiv:2606.16281

Who Should Lead Decoding Now? Tracking Reliable Trajectories for Ensembling Masked Diffusion Language Models

作者:

Heecheol Yun↗Joonhyung Park↗Joowon Kim↗Eunho Yang↗

Masked Diffusion Language Models (MDLMs) have emerged as a distinct paradigm for sequence generation. As MDLMs become diverse in capabilities and knowledge coverage, an important question is how to combine their knowledge. Toward this, we first investigate the unique decoding dynamics of MDLMs. We find that successful generations exhibit stable confidence dynamics over answer-relevant positions, while unreliable trajectories can often be corrected by injecting promising intermediate states from other models. Guided by this observation, we propose $TIE$ ($T$rajectory-based $I$terative $E$nsembling), a knowledge fusion framework in which MDLMs iteratively identify reliable decoding trajectories and relay them across models. TIE tracks confidence dynamics over answer-relevant positions to determine which model currently follows a more reliable trajectory and selectively transfers partially denoised sequences across models. As the model on the more promising trajectory often changes across denoising steps, TIE allows different models to contribute complementary strengths at different stages of generation. Strong performance across diverse reasoning tasks, along with our analyses, suggests that TIE offers a practical approach to the underexplored problem of MDLM ensembling.

阅读与讨论 → 访问原文 →

03.

arXiv (CS.CV) 2026-06-17 DOI: arXiv:2606.17958

Beyond Visual Cues: CoT-Enhanced Reasoning for Semi-supervised Medical Image Segmentation

作者:

Yuming Chen↗Yuxin Xie↗Tao Zhou↗Yi Zhou↗

Semi-supervised medical image segmentation has emerged as a dominant research problem in medical image analysis, mitigating annotation scarcity by leveraging consistency regularization on unlabeled data. However, existing approaches operate predominantly via visual pattern matching, relying heavily on pixel-level similarities. This visual-centric dependency often falters in clinical scenarios characterized by the visual-semantic mismatch, where visually similar lesions warrant distinct diagnostic conclusions, thus failing to capture the underlying diagnostic logic used by experts. To address this, we move beyond visual cues and propose CERS (CoT-Enhanced Reasoning Segmentation), a framework that integrates Chain-of-Thought (CoT) reasoning to distinguish pathologically distinct cases. Specifically, we construct a knowledge pool enriched with linguistic reasoning descriptions generated by large language models (LLMs). A semantic-aware reference selection strategy is introduced to identify historical evidence, filtering candidates first by morphology, and then refining them via CoT consistency to eliminate hard negatives. Furthermore, a multi-scale coordinate attention module (MCAM) is designed to effectively fuse this reasoning-derived context into the decoding process. Extensive experiments demonstrate the superiority of CERS against state-of-the-art approaches, particularly in resolving boundary ambiguities and semantic inconsistencies. The code is available at https://github.com/cymasuna/CERS.

阅读与讨论 → 访问原文 →

04.

arXiv (quant-ph) 2026-06-24 DOI: arXiv:2508.21490

Testing quantum-like markers in neural dynamics

作者:

Partha Ghose↗Dimitris Pinotsis↗

arXiv:2508.21490v3 Announce Type: replace-cross Abstract: We propose two experiments for identifying quantum markers in neural data based on quantum variants of well-known equations for neural activity that describe electrical signal propagation on axonal arbors and dendrites. These include (i) testing if power spectra from subthreshold oscillations in neuronal cultures follow the classical Fitzgugh-Nagumo equations or a recently introduced quantum variant of them and (ii) testing if propagation statistics of electrical activity in axons follow the classical diffusive cable equation or a quantum variant of it.

阅读与讨论 → 访问原文 →

05.

medRxiv (Medicine) 2026-06-17 DOI: HASH:1bcd9b5f336e54dc2fa6e5190e58778a

LLM-Driven Extraction of NI-RADS and Imaging Tumor Characteristics to Enhance Oropharyngeal Cancer Survivorship Surveillance

作者:

Song↗Shbita↗Jang↗I. J. H↗Starostina↗Lewis↗Sahli↗Floyd↗W. R↗Mahin↗Rinsurongkawong↗Barbon↗…

Abstract Purpose Radiologic surveillance is essential for oropharyngeal cancer (OPC) survivors, guiding recurrence detection and follow-up strategies. The Neck Imaging Reporting and Data System provides a standardized framework for post-treatment risk reporting at both the primary tumor site (pNI-RADs) and cervical lymph nodes (nNI-RADS). Comprehensive surveillance additionally requires assessment of disease status, including the primary tumor, nodal involvement, and distant metastases. These clinical results are often embedded as unstructured data within free-text radiology reports. We hypothesized that a large language model (LLM) can reliably extract NI-RADS score criteria and summarize key imaging features from unstructured radiology text, achieving high concordance with expert review. Methods Previously untreated OPC patients who received definitive cancer therapy were identified. Eligible imaging reports included post-treatment head and neck CT, MRI, or FDG PET/CT scans containing narrative and impression text. Examinations lacking narrative or impression text, containing pre-existing NI-RADS annotations, or involving non-surveillance imaging modalities were excluded. A total of 200 reports were randomly selected from 7,076 eligible examinations for manual abstraction using a three-reviewer consensus framework to establish a reference dataset. Using the Palantir Foundry Pipeline Builder, a GPT-5-based LLM was deployed to extract pNI-RADS and nNI-RADS scores, and key imaging features of disease status from these reports. Performance was evaluated using exact agreement and F1-based metrics. Results Agreement for no evidence of disease (score of 1) was 93.3% (126/135; F1 = 0.94) and 90.3% (130/144; F1 = 0.93) for pNI-RADS and nNI-RADS, respectively. For NI-RADS [≥]2, exact category agreement was 73.1% (38/52; macro-F1 = 0.75) for pNI-RADS and 64.3% (27/42; macro-F1 = 0.56) for nNI-RADS. Quadratic weighted {kappa} was 0.81 and 0.59, respectively. For post-treatment disease surveillance variables, agreement was 94.9% (149/157; F1 = 0.87) for primary tumor presence, 89.1% (164/184; F1 = 0.87) for nodal disease presence, and 94.7% (126/133; F1 = 0.70) for distant metastasis detection. Specificity was high across disease-status variables (0.95-0.99), with negative predictive values of 0.95 for primary tumor, 0.87 for nodal disease, and 0.99 for distant metastasis. Conclusions Our LLM-based information retrieval and classification approach for radiographic treatment response from unstructured, multidimensional imaging reports achieved high performance for disease exclusion and moderate performance for detecting suspected residual and/or new disease. This pipeline supports scalable and standardized surveillance data capture for longitudinal monitoring, clinical analytics, and survivorship research in head and neck oncology.

阅读与讨论 → 访问原文 →

06.

bioRxiv (Bioinfo) 2026-06-15 DOI: HASH:7dfc4d6b7e129cac3c3b5baa70bf6b0d

Inferring Cell Fate Trajectories in Time-Resolved Metabolic RNA Labeling data

作者:

Audit↗Peyre↗Cantini↗

Single-cell RNA sequencing provides high-resolution snapshots of cellular states but lacks direct information about transcriptional dynamics. Metabolic RNA labeling addresses this limitation by distinguishing newly synthesized RNA, offering insight into the direction of cell state changes, and providing valuable information when attempting to recover the underlying continuous dynamics from static snapshots of cell distributions. However, existing trajectory inference methods do not fully exploit this additional signal. Here, we propose FLOWSATATE, a framework for single-cell trajectory inference that leverages time-resolved RNA labeling within an Optimal Transport setting. We model cell dynamics as a gradient flow in an inferred potential landscape parameterized by a neural network, integrating both total and labeled RNA across time points. The learned potential enables identification of key genes and transcription factors driving cell fate decisions and supports prediction of future cellular states. We benchmark our approach on its ability to generalize unseen data and recover coherent trajectories. We also apply it to study colorectal cancer response to demethylation treatment as well as neuronal differentiation of embryonic stem cells.

阅读与讨论 → 访问原文 →

07.

arXiv (CS.CL) 2026-06-15 DOI: arXiv:2505.12992

Fractured Chain-of-Thought Reasoning

作者:

Baohao Liao↗Hanze Dong↗Yuhui Xu↗Doyen Sahoo↗Christof Monz↗Junnan Li↗Caiming Xiong↗

Inference-time scaling techniques have significantly bolstered the reasoning capabilities of large language models (LLMs) by harnessing additional computational effort at inference without retraining. Similarly, Chain-of-Thought (CoT) prompting and its extension, Long CoT, improve accuracy by generating rich intermediate reasoning trajectories, but these approaches incur substantial token costs that impede their deployment in latency-sensitive settings. In this work, we first show that truncated CoT, which stops reasoning before completion and directly generates the final answer, often matches the full CoT sampling while using dramatically fewer tokens. Building on this insight, we introduce Fractured Sampling, a unified inference-time strategy that interpolates between full CoT and solution-only sampling along three orthogonal axes: (1) the number of reasoning trajectories, (2) the number of final solutions per trajectory, and (3) the depth at which reasoning traces are truncated. Through extensive experiments on five diverse reasoning benchmarks and several model scales, we demonstrate that Fractured Sampling consistently achieves superior accuracy-cost trade-offs, yielding steep log-linear scaling gains in Pass@k versus token budget. Our analysis reveals how to allocate computation across these dimensions to maximize performance, paving the way for more efficient and scalable LLM reasoning. Code is available at https://github.com/BaohaoLiao/frac-cot.

阅读与讨论 → 访问原文 →

08.

arXiv (CS.CV) 2026-06-12 DOI: arXiv:2402.01779

Plug-and-Play image restoration with Stochastic deNOising REgularization

作者:

Marien Renaud↗Jean Prost↗Arthur Leclaire↗Nicolas Papadakis↗

Plug-and-Play (PnP) algorithms are a class of iterative algorithms that address image inverse problems by combining a physical model and a deep neural network for regularization. Even if they produce impressive image restoration results, these algorithms rely on a non-standard use of a denoiser on images that are less and less noisy along the iterations, which contrasts with recent algorithms based on Diffusion Models (DM), where the denoiser is applied only on re-noised images. We propose a new PnP framework, called Stochastic deNOising REgularization (SNORE), which applies the denoiser only on images with noise of the adequate level. It is based on an explicit stochastic regularization, which leads to a stochastic gradient descent algorithm to solve ill-posed inverse problems. A convergence analysis of this algorithm and its annealing extension is provided. Experimentally, we prove that SNORE is competitive with respect to state-of-the-art methods on deblurring and inpainting tasks, both quantitatively and qualitatively.

阅读与讨论 → 访问原文 →

09.

arXiv (CS.CL) 2026-06-18 DOI: arXiv:2606.18686

ForecastBench-Sim: A Simulated-World Forecasting Benchmark

作者:

Jaeho Lee↗Nick Merrill↗Ezra Karger↗

Forecasting benchmarks for general-purpose AI systems usually inherit the constraints of the real world: outcomes resolve slowly, tail events are rare, and counterfactual questions are difficult to score. We introduce ForecastBench-Sim, a simulated-world forecasting benchmark built on game rollouts from Freeciv, a turn-based strategy game modelled on the Civilization series. Forecasters receive a fixed world report (a structured snapshot of the current game state) and answer questions about hidden future states; the benchmark then continues the simulation and scores forecasts. Because the world is simulated, the same setup can generate continuous or binary forecasting questions at arbitrary time horizons, paired intervention worlds for conditional or causal questions, and resolved examples of rare or disruptive outcomes. We describe the benchmark pipeline, question families, scoring protocol, and release artifacts, and report validation slices from model evaluations and an anonymized human pilot. ForecastBench-Sim is intended to complement real-world forecasting benchmarks by providing controlled, immediately resolvable tasks for studying probabilistic reasoning under dynamic world states.

阅读与讨论 → 访问原文 →

10.

medRxiv (Medicine) 2026-06-15 DOI: HASH:b239d8187fe84995897c4fd55fbe9868

Quantitative Gait Categorization in Parkinson's Disease with and without Freezing of Gait

作者:

Donovan↗Tripathi↗Chu↗Bernhard↗Factor↗McKay↗J. L↗Esper↗

Background: Freezing of gait (FOG) is a disabling and often underrecognized feature of Parkinsons disease (PD). Objective gait analysis may improve characterization of this motor symptom. Objective: To compare quantitative 3D gait parameters in PD with FOG (PDF) and PD without FOG (PDNF) in a routine clinical cohort. Methods: We retrospectively analyzed a sequential sample of 180 patients with PD referred for motion analysis between 2020 and 2024. All patients underwent 3D motion capture in the off-medication state. Eighteen gait outcomes spanning pace, rhythm, postural control, variability, and asymmetry domains were derived from steady-state walking tasks. FOG status was determined using physician documentation and Movement Disorder Society Unified Parkinsons Disease Rating Scale (MDS-UPDRS) items. Group differences between PDF (n=99) and PDNF (n=81) were evaluated using independent samples t-tests, with outcomes adjusted for disease duration and corrected for multiple comparisons. A secondary analysis among PDF compared those in Hoehn and Yahr (H&Y) stage [≥]III to those in H&Y [≤]II. Results: PDF had longer disease duration, higher OFF MDS-UPDRS III scores, and higher Hoehn and Yahr stage than PDNF but were similar in age and sex. After adjusting for disease duration and multiplicity, PDF demonstrated reduced step length, stride length, and forward velocity, and greater cadence variability, while most postural control, and asymmetry measures were comparable between groups. Among PDF, advanced H&Y stage was associated with impaired pace and rhythm, similar to previous reports among PD in general. Conclusion: In this large, sequential, clinically referred cohort, FOG was associated with more advanced PD and specific impairments in pace and gait variability. These findings support comprehensive 3D gait analysis as an objective tool to better delineate FOG-related gait abnormalities and identify features that may predict FOG, informing targeted interventions.

阅读与讨论 → 访问原文 →

11.

arXiv (CS.CL) 2026-06-15 DOI: arXiv:2606.14199

OdysSim: Building Foundation Models for Human Behavior Simulation

作者:

Xuhui Zhou↗Weiwei Sun↗Weihua Du↗Jiarui Liu↗Haojia Sun↗Qianou Ma↗Tongshuang Wu↗Yiming Yang↗Maarten Sap↗

Large language models are increasingly deployed as human simulators for interactive evaluation and social simulation. Yet helpfulness-driven post-training pulls them toward a homogeneous, overly agreeable assistant register, creating a behavioral Sim2Real gap. We present OdysSim, the largest open systematic investigation of behavioral foundation models, i.e., models trained to simulate human behavior at scale. We propose SOUL, a taxonomy of five capability axes (CONV, SS, COG, ROLE, EVAL) that unifies 62 datasets and 23 benchmark tasks under one framework. Specifically, we curate the OdysSim corpus (21.4M interactions, 10B tokens, retrofitted with back-generated social contexts), construct the SOUL-Index benchmark, and develop an end-to-end training recipe combining midtraining, task-specific RL, and expert distillation. The resulting open 8B OSim model ranks first or tied-first on 8 of 23 tasks, outperforming any individual frontier model by this count, with the strongest gains on conversational and social tasks. Its outputs are also more human-like in length, formatting, and word choice, and it transfers zero-shot to out-of-distribution user simulation on $\tau$-bench, nearly matching real users on reaction alignment (93.2 vs. 93.5). We further show that LLM-as-judge RL induces reward-hacking patterns, and that our detectors can mitigate them during post-training. Together, our findings suggest that behavioral foundation models require rethinking the LLM training paradigm. We release all artifacts to support future research.

阅读与讨论 → 访问原文 →

12.

arXiv (CS.LG) 2026-06-11 DOI: arXiv:2606.11629

Integral Formulation of QENDy for Robust Nonlinear System Identification

作者:

Nikhil Saran↗Sushant Pokhriyal↗Stefan Klus↗Rushikesh Kamalapurkar↗Joel A. Rosenfeld↗

arXiv:2606.11629v1 Announce Type: cross Abstract: This manuscript proposes an integral formulation of the newly defined quadratic embedding method for identifying nonlinear systems (QENDy). In the original algorithm, trajectory data points along with their time derivatives are used. Methods for calculating time derivatives make the algorithm sensitive to noise. Our integral formulation does not use the time derivatives. This results in a more robust method to learn the dynamics.

阅读与讨论 → 访问原文 →

13.

medRxiv (Medicine) 2026-06-24 DOI: HASH:5864d8464b4a9aa838ee639e86eaed0f

A Multidomain Model for Dementia Classification using Harmonized LASI and LASI-DAD Data

作者:

Anand↗Miyapuram↗

ABSTRACT Dementia classification in heterogeneous populations is complicated by the influence of education, language, socioeconomic position and health status on cognitive test performance. Approaches that rely on fixed cognitive thresholds or isolated predictor sets may therefore perform inconsistently across diverse older adult populations. We developed and internally validated a multidomain classification model using harmonized data from the Longitudinal Ageing Study in India (LASI) and its diagnostic sub-study, LASI-DAD. Clinical dementia status was defined as a binary outcome derived from consensus-based Clinical Dementia Rating (CDR) assessments, averaged across 20 multiply imputed outcome datasets and finalised using a 0.5 threshold. The analytic sample comprised 3,186 participants after exclusion of those with mild cognitive impairment. Twenty-two predictors spanning cognitive performance, informant-reported decline, cardiometabolic biomarkers and sociodemographic characteristics were retained. Missing predictor values were addressed using k-nearest neighbours imputation. Model development used a stratified 70:30 train-test split, with nested cross-validation conducted within the training set only, and class imbalance corrected using the Synthetic Minority Oversampling Technique (SMOTE) applied exclusively within training folds. Five supervised learning approaches were evaluated: logistic regression, random forest, gradient boosting, XGBoost and support vector machines. The final logistic regression model achieved an area under the receiver operating characteristic curve (ROC-AUC) of 0.932 and an average precision of 0.668 on the held-out set. At the optimal probability threshold of 0.70, sensitivity was 0.771, specificity was 0.905, positive predictive value was 0.325 and negative predictive value was 0.985. A cognition-only comparator, restricted to task-based cognitive measures and run through the same pipeline, yielded a ROC-AUC of 0.908 and average precision of 0.620, indicating incremental discriminatory value from the full multidomain feature set. Dementia prevalence increased progressively across model-derived risk strata, reaching approximately 50% in the highest category. Permutation importance and SHAP analyses identified informant-reported decline and orientation as the strongest contributors to classification, with cardiometabolic variables providing smaller but consistent incremental contributions. Dementia classification in a socially and clinically heterogeneous Indian cohort can be improved by integrating cognitive, informant, cardiometabolic and sociodemographic information within a single interpretable model. The strongest predictive signal was carried by cognitive and informant measures, with non-cognitive features adding structure around that core. The model requires external validation and calibration before broader application can be considered. Keywords - dementia; classification; multidomain modelling; machine learning; interpretability; older adults; India; LASI-DAD

阅读与讨论 → 访问原文 →

14.

arXiv (CS.AI) 2026-06-17 DOI: arXiv:2606.17667

Handling Feature Heterogeneity with Learnable Graph Patches

作者:

Yifei Sun↗Yang Yang↗Xiao Feng↗Zijun Wang↗Haoyang Zhong↗Chunping Wang↗Lei Chen↗

arXiv:2606.17667v1 Announce Type: cross Abstract: In recent years, the rapid development of foundation models and graph pre-training technologies has spurred increasing interest in constructing a universal pre-trained graph model or Graph Foundation Model (GFM). However, a significant challenge is that existing models are unable to address feature heterogeneity in graph data without textual information, which hinders the transferability of graph models across different datasets. To bridge this gap, we propose the concept of learnable graph patches, which we regard as the smallest semantic units of any graph data. We decompose the graph into learnable graph patches by unfolding the node features and constructing corresponding patch structures separately. We then design a framework that mines transferable information from graph data across domains. Specifically, after extracting graph patches, we propose a patch encoder to extract knowledge from each unit and a patch aggregator to learn how the units are combined into a whole. Due to its domain-agnostic nature, the model can be applied to downstream data across different domains. Furthermore, we analyze the connection between our method and existing graph models, as well as the transferability of the node embeddings it generates. Empirically, our method not only achieves the capability to use multi-domain graphs for pre-training, but also shows enhanced performance across various downstream datasets and tasks. Moreover, we observe consistent improvement in downstream performance as the volume of pre-training data increases.

阅读与讨论 → 访问原文 →

15.

arXiv (CS.AI) 2026-06-12 DOI: arXiv:2602.00343

Standardized Methods and Recommendations for Green Federated Learning

作者:

Austin Tapp↗Holger R. Roth↗Ziyue Xu↗Abhijeet Parida↗Hareem Nisar↗Marius George Linguraru↗

arXiv:2602.00343v2 Announce Type: replace-cross Abstract: Federated learning (FL) enables collaborative model training over privacy-sensitive, distributed data, but its environmental impact is difficult to compare across studies due to inconsistent measurement boundaries and heterogeneous reporting. We present a practical carbon-accounting methodology for FL CO2e tracking using NVIDIA NVFlare and CodeCarbon for explicit, phase-aware tasks (initialization, per-round training, evaluation, and idle/coordination). To capture non-compute effects, we additionally estimate communication emissions from transmitted model-update sizes under a network-configurable energy model. We validate the proposed approach on two representative workloads: CIFAR-10 image classification and retinal optic disk segmentation. In CIFAR-10, controlled client-efficiency scenarios show that system-level slowdowns and coordination effects can contribute meaningfully to carbon footprint under an otherwise fixed FL protocol, increasing total CO2e by 8.34x (medium) and 21.73x (low) relative to the high-efficiency baseline. In retinal segmentation, swapping GPU tiers (H100 vs.\ V100) yields a consistent 1.7x runtime gap (290 vs. 503 minutes) while producing non-uniform changes in total energy and CO2e across sites, underscoring the need for per-site and per-round reporting. Overall, our results support a standardized carbon accounting method that acts as a prerequisite for reproducible 'green' FL evaluation. Our code is available at https://github.com/Pediatric-Accelerated-Intelligence-Lab/carbon_footprint.

阅读与讨论 → 访问原文 →

16.

arXiv (CS.CV) 2026-06-19 DOI: arXiv:2606.19641

Scaling Self-Play for End-to-End Driving

作者:

Luke Rowe↗Roger Girgis↗Rodrigue de Schaetzen↗Daphne Cornelisse↗Alaap Grandhi↗Felix Heide↗Eugene Vinitsky↗Christopher Pal↗Liam Paull↗

End-to-end autonomous driving models are typically trained on offline human-demonstration datasets that provide limited state coverage and often no closed-loop feedback, making them prone to compounding errors when deployed in closed-loop and brittle to long-tail agent interactions. To overcome these limitations, we propose an alternative strategy for training end-to-end driving models: large-scale self-play directly from pixels in simulation. While prior self-play approaches have shown promising transfer to real-world driving, they typically assume vectorized Bird's-Eye-View (BEV) observations that are incompatible with end-to-end policies operating directly on sensor observations. To this end, we introduce Gigapixel, a high-throughput batched driving simulator with perspective rendering, enabling scalable self-play directly from pixel observations. Rather than targeting compute-costly photorealistic sensor simulation, Gigapixel renders a simplified bounding-box world that preserves essential scene structure while achieving throughput at 50k agent steps per second. Since direct pixel-space self-play RL is prohibitively sample-inefficient at end-to-end model scale, we propose self-play DAgger training: we train pixel-based policies in self-play via on-policy distillation from a privileged RL teacher. To bridge the sim-to-real gap, we subsequently transfer the self-play trained policies to real-world sensor data through lightweight perception adaptation. Policies trained in Gigapixel and adapted to real-world sensor data achieve competitive performance on the HUGSIM and NAVSIM-v2 benchmarks without human trajectory supervision. Moreover, scaling self-play training yields proportional gains in policy performance, establishing self-play as a practical and scalable strategy for training end-to-end models.

阅读与讨论 → 访问原文 →

17.

arXiv (CS.AI) 2026-06-17 DOI: arXiv:2606.18154

Learning Cardiac Electrophysiology Digital Twins Through Agentic Discovery of Hybrid Structure

作者:

Ziqi Zhou↗Yubo Ye↗Sumeet Atul Vadhavka↗Linwei Wang↗Zhiqiang Tao↗

arXiv:2606.18154v1 Announce Type: new Abstract: Building personalized cardiac electrophysiology (EP) digital twins requires identifying the appropriate model structure for each patient, not merely fitting parameters. Traditional methods rely on experts to manually prescribe hybrid physics-neural architectures, which requires deep domain expertise and does not transfer across patients. Recent works have applied large language models (LLMs) to generate or act as hybrid models. However, despite their promising generalization capacity, these LLM-based methods lack the structural priors needed for stable cardiac simulations. Hence, we propose LEADS, a framework that formulates cardiac EP domain knowledge as a structured action space and utilizes an LLM agent to discover hybrid models. The agent follows an iterative reasoning-and-action loop to select, combine, and refine hybrid models, whilst gradient descent handles parameter fitting. The proposed LEADS designs every candidate model towards physically grounded, interpretable, and numerically stable, while allowing open-ended architectural discovery. We validate LEADS on synthetic data with three ground-truth reaction models and on real cardiac EP data, demonstrating that it outperforms both human-designed hybrid models and other LLM-based hybrid modeling.

阅读与讨论 → 访问原文 →

18.

arXiv (quant-ph) 2026-06-17 DOI: arXiv:2606.18084

Cavity-enhanced superconducting response in an underdoped cuprate

作者:

Angela Montanaro↗Vadim Plastovets↗Nitesh Khatiwada↗Jacopo Fiore↗Giacomo Jarc↗Abdullah Alabbadi↗Antonio Mastropasqua↗Enrico Maria Rigoni↗Shahla Y. Mathengattil↗Simone Dal Zilio↗Francesca Fassioli Olsen↗Fabio Novelli↗…

arXiv:2606.18084v1 Announce Type: cross Abstract: Superconductors carry electrical current without resistance when paired electrons condense into a coherent macroscopic quantum state. In underdoped cuprates, evidence suggests that pairing-related correlations and superconducting fluctuations can survive above the temperature at which global coherence is lost, pointing to phase fluctuations as a key limitation on superconductivity in this regime. Motivated by recent demonstrations of cavity-modified collective states in quantum materials, we investigate whether superconducting coherence can be stabilized by engineering the electromagnetic environment of the superconductor. We study an underdoped YBa$_2$Cu$_3$O$_{7-\delta}$ thin film in a tunable terahertz cavity formed with a semi-transparent gold mirror. From temperature-dependent terahertz transmission measurements, we find that the cavity enhances the superconducting response below the critical temperature, with an increase of the inferred superfluid weight. The effect becomes more pronounced at smaller cavity lengths and is accompanied by an upward shift of the superconducting onset temperature. Calculations based on a cavity-coupled model for phase-fluctuating superconductors capture these trends and support an interpretation in terms of cavity-enhanced phase stiffness. These results showcase the potential of cavity engineering for designing emergent functionalities in correlated systems.

阅读与讨论 → 访问原文 →

19.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2602.04789

Light Forcing: Accelerating Autoregressive Video Diffusion via Sparse Attention

作者:

Chengtao Lv↗Yumeng Shi↗Yushi Huang↗Ruihao Gong↗Shen Ren↗Wenya Wang↗

Advanced autoregressive (AR) video generation models have improved visual fidelity and interactivity, but the quadratic complexity of attention remains a primary bottleneck for efficient deployment. While existing sparse attention solutions have shown promise on bidirectional models, we identify that applying these solutions to AR models leads to considerable performance degradation for two reasons: isolated consideration of chunk generation and insufficient utilization of past informative context. Motivated by these observations, we propose \textsc{Light Forcing}, the first sparse attention solution tailored for AR video generation models. It incorporates a Chunk-Aware Growth mechanism to quantitatively estimate the contribution of each chunk, which determines their sparsity allocation. This progressive sparsity increase strategy enables the current chunk to inherit prior knowledge in earlier chunks during generation. Additionally, we introduce a Hierarchical Sparse Attention to capture informative historical and local context in a coarse-to-fine manner. Such two-level mask selection strategy (i.e., frame and block level) can adaptively handle diverse attention patterns. Extensive experiments demonstrate that our method outperforms existing sparse attention in quality (e.g., 84.5 on VBench) and efficiency (e.g., $1.2{\sim}1.3\times$ end-to-end speedup). Combined with other efficient solutions, \textsc{Light Forcing} further achieves a $2.0{\sim}3.0\times$ end-to-end speedup across diverse GPUs (e.g., 27.4\,FPS on RTX 5090 and 33.9\,FPS on H100). Code is released via this \href{https://github.com/chengtao-lv/LightForcing}{link}.

阅读与讨论 → 访问原文 →

20.

arXiv (quant-ph) 2026-06-24 DOI: arXiv:2606.18428

Quantum algorithm for Valiant-Vazirani reduction

作者:

Patrick Kelly↗Victoria S. Ordonez↗Michael R. Geller↗Yohannes Abate↗

arXiv:2606.18428v2 Announce Type: replace Abstract: There is growing interest in extensions of the standard model of gate-based quantum computation to include auxiliary degrees of freedom evolving according to a nonlinear Schrödinger equation. By reducing the Boolean satisfiability problem SAT to quantum state discrimination, Abrams and Lloyd argued that the right type of nonlinearity can be used to solve NP and #P problems in polynomial time, at least in an idealized noise-free limit. For practical implementation, however, we are restricted to simulated and emergent nonlinearities, such as that appearing in mean field models for ultracold atoms and similar ensembles. A prominent example is the torsion model, which arises in two-component Bose-Einstein condensates and spin models with all-to-all Ising interaction. But torsion-based state discrimination appears to fall short of solving SAT. Here we close this gap by constructing the filtered oracle of the Valiant-Vazirani theorem, providing a randomized polynomial-time reduction from SAT to UNIQUE SAT, a promise problem where there is at most 1 satisfying assignment. In the noise-free limit, the UNIQUE SAT problem can be solved in polynomial time using torsion nonlinearity. Quantum Valiant-Vazirani reduction is no faster than the efficient classical version, but a fault-tolerant implementation coupled to a nonlinear quantum coprocessor simulating torsion would enable polynomial time solution to NP (but not #P) problems.

阅读与讨论 → 访问原文 →

21.

arXiv (CS.CV) 2026-06-24 DOI: arXiv:2511.18037

Hybrid Event Frame Sensors: Modeling, Calibration, and Simulation

作者:

Yunfan Lu↗Nico Messikommer↗Xiaogang Xu↗Liming Chen↗Yuhan Chen↗Nikola Zubic↗Davide Scaramuzza↗Hui Xiong↗

Hybrid event-frame sensors integrate an Event Vision Sensor (EVS) and an Active Pixel Sensor (APS) within a single chip, combining the high dynamic range and low latency of the EVS with the rich spatial intensity information from the APS. While this tight integration offers compact and temporally precise imaging, the complex circuit architecture introduces nontrivial noise patterns that remain poorly understood and unmodeled. In this work, we present the first unified statistics-based imaging noise model that jointly describes the noise behavior of APS and EVS pixels. Our formulation explicitly incorporates photon shot noise, dark current noise, fixed-pattern noise, and quantization noise, and links EVS noise to illumination level and dark current. Based on this formulation, we further develop a calibration pipeline to estimate noise parameters from real data and provide a detailed analysis of both APS and EVS noise behaviors. Finally, we propose H-ESIM, a statistically grounded simulator that generates RAW frames and events under realistic jointly calibrated noise statistics. Experiments on two hybrid sensors validate our model across multiple imaging tasks, including video frame interpolation and deblurring, demonstrating strong transfer from simulation to real data.

阅读与讨论 → 访问原文 →

22.

arXiv (CS.LG) 2026-06-19 DOI: arXiv:2511.22283

The Hidden Cost of Approximation in Online Mirror Descent

作者:

Ofir Schlisselberg↗Uri Sherman↗Tomer Koren↗Yishay Mansour↗

arXiv:2511.22283v2 Announce Type: replace Abstract: Online mirror descent (OMD) is a fundamental algorithmic paradigm that underlies many algorithms in optimization, machine learning and sequential decision-making. The OMD iterates are defined as solutions to optimization subproblems which, oftentimes, can be solved only approximately, leading to an inexact version of the algorithm. Nonetheless, existing OMD analyses typically assume an idealized error free setting, thereby limiting our understanding of performance guarantees that should be expected in practice. In this work we initiate a systematic study into inexact OMD, and uncover an intricate relation between regularizer smoothness and robustness to approximation errors. When the regularizer is uniformly smooth, we establish a tight bound on the excess regret due to errors. Then, for barrier regularizers over the simplex and its subsets, we identify a sharp separation: negative entropy requires exponentially small errors to avoid linear regret, whereas log-barrier and Tsallis regularizers remain robust even when the errors are only polynomial. Finally, we show that when the losses are stochastic and the domain is the simplex, negative entropy regains robustness-but this property does not extend to all subsets, where exponentially small errors are again necessary to avoid suboptimal regret.

阅读与讨论 → 访问原文 →

23.

arXiv (CS.CV) 2026-06-12 DOI: arXiv:2605.01391

VISTA: Video Interaction Spatio-Temporal Analysis Benchmark

作者:

Alejandro Aparcedo↗Akash Kumar↗Aaryan Garg↗Dalton Pham↗Wen-Kai Chen↗Anirudh Bharadwaj↗Aman Chadha↗Yogesh Rawat↗

Existing benchmarks for Vision-Language Models (VLMs) primarily evaluate spatio-temporal understanding on simple single-action videos, closed attribute sets and restricted entity types, failing to capture the freeform, multi-action interactions between diverse entities which characterize real-world video understanding. Furthermore, the lack of a systematic framework for analyzing model failures across complementary spatio-temporal axes hinders comprehensive evaluation. To address these gaps, we introduce VISTA, a Video Interaction Spatio-Temporal Analysis benchmark designed for open-set, multi-entity and multi-action spatio-temporal understanding in VLMs. VISTA decomposes videos into interpretable entities, their associated actions, and relational dynamics, enabling multi-axis diagnostics and unified assessment of relational, spatial, and temporal understanding. Our benchmark integrates multiple datasets into a single interaction-aware taxonomy and comprises ~12K curated video-query pairs spanning diverse scenes and complexities. We systematically evaluate 11 state-of-the-art VLMs on VISTA, and break down aggregate performance across our taxonomy to reveal shortcomings and pronounced spatio-temporal biases obscured by traditional metrics. By providing detailed, taxonomy-driven diagnostics on a challenging dataset, VISTA offers a nuanced framework to guide advances in model design, pretraining strategies, and evaluation protocols. Overall, VISTA is the first, large-scale, interaction-aware diagnostic benchmark for spatio-temporal understanding in VLMs.

阅读与讨论 → 访问原文 →

24.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.11635

Are LLMs Bad at Moral Reasoning?

作者:

Menghang Zhu↗Seth Lazar↗

arXiv:2606.11635v1 Announce Type: cross Abstract: For highly capable AI systems to operate safely in dynamic, open-ended environments, they must be able to identify, understand, and respond to moral reasons for action, and constrain their behaviour accordingly. A growing body of research aims to evaluate this capacity – moral competence – in today's most capable AI systems, recently reaching broadly pessimistic conclusions. One of the most ambitious such papers collects gold-standard human-authored rubrics for evaluating moral reasoning in 1,000 cases, and benchmarks frontier AI models against those rubrics, with underwhelming results. In this paper, we argue that the MoReBench dataset can be redeployed to give a much more optimistic picture of LLMs' moral reasoning (an essential part of moral competence). We show that if, instead of scoring LLMs' responses to these cases against these rubrics, we instead give the LLMs the same task given to humans – to generate scoring rubrics for the moral analysis of particular cases – the rubrics they generate are both better calibrated to the human rubrics than their open-ended responses, and, where they differ, plausibly reflect nothing more than the vast dimensionality of most moral problems, as well as highlighting some human departures from the "rubric for creating rubrics". Taking these points into consideration, the MoReBench dataset suggests that LLMs are significantly more capable at moral reasoning than was previously believed.

阅读与讨论 → 访问原文 →

25.

arXiv (CS.LG) 2026-06-12 DOI: arXiv:2603.17527

Mirror Descent on Riemannian Manifolds

作者:

Jiaxin Jiang↗Lei Shi↗Jiyuan Tan↗

arXiv:2603.17527v2 Announce Type: replace-cross Abstract: Mirror Descent (MD) is a scalable first-order method widely used in large-scale optimization, with applications in image processing, policy optimization, and neural network training. This paper generalizes MD to optimization on Riemannian manifolds. In particular, we develop a Riemannian Mirror Descent (RMD) framework via reparameterization and further propose a stochastic variant of RMD. We also establish non-asymptotic convergence guarantees for both RMD and stochastic RMD. As an application to the Stiefel manifold, our RMD framework reduces to the Curvilinear Gradient Descent (CGD) method proposed in [26]. Moreover, when specializing the stochastic RMD framework to the Stiefel setting, we obtain a stochastic extension of CGD, which effectively addresses large-scale manifold optimization problems.

阅读与讨论 → 访问原文 →