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01.
Nature Medicine 2026-06-12

The Hong Kong Genome Project is a flagship initiative for precision medicine in Chinese populations

作者: 未知作者

The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing drug prescriptions. This work establishes a genomic resource and a transferable model for equitable precision medicine in underrepresented populations worldwide.

02.
arXiv (quant-ph) 2026-06-11

Super-Heisenberg Non-Equilibrium Quantum Sensing with Waveguide-Coupled Emitters

arXiv:2606.11975v1 Announce Type: new Abstract: We explore an array of quantum emitters as non-equilibrium probes, coupled to a one-dimensional photonic waveguide, aiming to estimate its properties such as wave number which encodes the waveguide frequency and dispersive characteristics. By considering transient dynamics following initial excitation, we show that the quantum Fisher information (QFI) can be significantly enhanced through careful emitter positioning. For two-emitter probes, optimal spacing stabilizes populations and coherences in the single-excitation subspace, suppressing super radiant decay and extending both the magnitude and longevity of QFI. Randomized emitter configurations also reveal that vanishing waveguide-mediated cross decay maximizes both achievable sensitivity and the temporal duration over which information about the parameter remains accessible. Extending to multipartite probes, we demonstrate that the maximum QFI and its temporal integral scale with system size, exceeding the Heisenberg limit for all positioning strategies. Our results highlight the potential of waveguide-coupled emitter arrays as versatile quantum sensors, where collective radiative dynamics can be harnessed to achieve tunable, long-lived, and enhanced precision.

03.
arXiv (CS.CL) 2026-06-11

DuDi: Dual-Signal Distillation with Cross-Lingual Verbalizer

Small language models (SLMs) are efficient and scalable, but their multilingual capabilities degrade severely at sub-billion scales, especially for Southeast Asian (SEA) languages. We introduce DuDi, a dual-signal multilingual distillation framework that combines an online sequence-level signal with off-policy and on-policy token-level signals. DuDi further uses a cross-lingual verbalizer to refine teacher feedback and improve teacher-student transferability in multilingual settings. Experiments on SEA-HELM across multiple model families, scales, and teacher-student settings show that DuDi consistently outperforms competitive distillation baselines. Ablations and analyses confirm that sequence-level optimization, token-level supervision, and cross-lingual verbalization provide complementary and transferable learning signals for multilingual SLMs.

04.
arXiv (quant-ph) 2026-06-17

Practical Tests and Witnesses of Fermionic non-Gaussianity

arXiv:2605.26218v2 Announce Type: replace Abstract: Fermionic Gaussian states describe free fermions and underlie the mean-field picture of matter, from metals to superconductors; they are also efficiently simulable on classical computers. Departures from Gaussianity – the correlations produced by interactions – are therefore what make a fermionic system hard to simulate classically and useful for quantum computation, analogous to the role of magic in stabilizer-based quantum computation. Yet detecting and quantifying such non-Gaussianity at scale has remained challenging. Here we introduce practical tests and witnesses of fermionic non-Gaussianity built on fermionic antiflatness, a measure derived from the two-point covariance matrix. We estimate it with two protocols – a two-copy Bell measurement and a single-copy scheme using commuting Majorana bilinears – that determine whether a state is Gaussian or far from it at lower measurement cost than existing approaches, using only operations native to fault-tolerant hardware. For mixed states, a purity-corrected witness certifies non-Gaussianity and remains robust under strong noise; running it on the IQM quantum processor, we find that noise can both reduce and enhance non-Gaussianity. Finally, we show that preparing pseudorandom fermionic states requires extensive non-Gaussianity. Together, these tools enable the study and certification of non-Gaussian fermionic resources on present-day quantum devices.

05.
arXiv (CS.CL) 2026-06-25

Space-Efficient Language Generation in the Limit

We initiate a resource-aware theory of language generation in the limit under the minimal constraint of space efficiency. In our framework, a learner observes an adversarial positive stream from a target language $K$ and must eventually output a hallucination-free hypothesis language $L \subseteq K$ while omitting at most $\Delta$ strings of $K$. We focus on $\mathcal{C}_{s,k}$, the collection of languages recognized by DFAs with at most $s$ states over an alphabet of size $k$, as the natural hypothesis class for memory-bounded learners. In the exponential-space regime, we prove that a learner can exactly identify the target $K$. Under a stricter memory budget, we characterize the strongest possible generation guarantees. In particular, we present a streaming algorithm using $\mathrm{poly}(s,k)$ space that converges to a hypothesis with generation gap $\Delta = O(k^{2s-2})$. Moreover, the learned hypothesis captures every string in $K$ of length at least $2s-1$. We complement this result with a near-matching lower bound through a reduction from a standard communication complexity problem. Specifically, achieving generation gap $\Delta \le k^{(1-\varepsilon)s}$ requires $k^{\Omega(\varepsilon s)}$ memory. Together, these results reveal a sharp transition between polynomial-space generation and exponential-space exact identification.

06.
arXiv (CS.CV) 2026-06-18

Investigation of Neural Network Methods for Reconstruction and Classification of Texture Images Under Conditions of Incomplete Information

The automated analysis of heterogeneous natural textures is frequently hindered by physical damage and data loss, presenting a significant challenge to computer vision. While deep learning has shown success in controlled environments, its application to complex geological materials under conditions of incomplete information remains underexplored. This study presents an integrated framework for the inpainting and classification of high-resolution core sample images. We propose an end-to-end pipeline that utilizes object detection for sample segmentation, followed by image inpainting using Generative Adversarial Networks (GANs) with Contextual Residual Aggregation (CRA) to reconstruct missing high-frequency details. Subsequently, we evaluate the performance of modern Transformer-based (Swin, ViT) and CNN architectures on the reconstructed data. Our experiments revealed a critical divergence between reconstruction quality and downstream utility: despite high structural fidelity (PSNR 28.7~dB, FID 74.01), classification accuracy plateaued at 53\%. To improve minority-class detection, we propose a confidence-based hybrid ensemble that raises MCA from 48\% to 58\%. These results highlight the limitations of current state-of-the-art generative models, which may produce visually plausible but semantically ambiguous features ("hallucinations") that confound classifiers. This work provides insights into the dependencies between image reconstruction quality and classification performance, offering a reproducible baseline for future research in non-destructive testing and material science. Given that cross-well accuracy remains in the 49–53\% range, we position the resulting system as a decision-support and screening tool for lithofacies interpretation rather than as a fully autonomous classifier. The code is available at https://github.com/GalymzhanAbdimanap/Lithology_recognition

07.
arXiv (CS.CL) 2026-06-25

Optimizing Abstractive Summarization With Fine-Tuned PEGASUS

Abstractive text summarization is the technique of generating a short and concise summary comprising the salient ideas of a source text without making a subset of the salient sentences from the source text. The introduction of transformer models such as BART, T5, and PEGASUS has made this sort of summarization process more efficient and accurate. The objective of this paper is to fine-tune PEGASUS on the XL-Sum English corpus to achieve a better performance compared to the baseline mT5 model. The performance of the generated summaries from the fine-tuned model is evaluated using the ROUGE metric, which basically compares the auto-generated summaries with human-created summaries. To the best of our knowledge, the results from our fine-tuned PEGASUS model give a state-of-the-art performance on the XL-Sum English Corpus. To quantify the improvement, there is a 4.04% improvement in the ROUGE-1 score, a 15.25% increase in the ROUGE-2 score, and a 3.39% improvement in the ROUGE-L score from the baseline model.

08.
arXiv (CS.CV) 2026-06-24

Training-free Cross-domain Few-shot Segmentation via Robust Semantic Representation and Matching

Cross-domain Few-shot Segmentation (CD-FSS) aims to transfer knowledge learned from source domain to distinct target domains, segmenting unseen target classes with only a few annotated samples. Although existing methods have made significant progress, they still rely on training or fine-tuning processes, which incur high computational costs and risk overfitting. We observe that when powerful and general-purpose vision foundation models are incorporated into these methods, their performance shows only marginal improvement or even degrades due to overfitting. To address this, we eliminate trainable parameters and propose a training-free framework to avoid both training overhead and overfitting. Built upon the self-supervised vision encoder DINOv3, our framework addresses cross-domain challenges through three core modules. First, the Semantic-aware Feature Re-fusion (SAFR) module identifies and re-fuses features that emphasize semantic patterns, generating representations with enhanced semantic discriminability. Additionally, the Adaptive Support Enhancement (ASE) module narrows semantic gaps between support and query through robust query information aggregation. Finally, the Hybrid Prototype Matching (HPM) module integrates matching results from diverse prototypes to adapt to varying semantic complexity across domains. Extensive experiments on four target domain datasets demonstrate that our method achieves state-of-the-art performance in CD-FSS without any training.

09.
arXiv (CS.LG) 2026-06-18

A finite-element-inspired bipartite graph learned simulator for manufacturability assessment in large-deformation sheet forming

arXiv:2605.22845v2 Announce Type: replace-cross Abstract: Explicit dynamic finite element (FE) simulations are widely used for large deformation engineering analysis, but repeated simulations remain costly during design space exploration and optimisation. In explicit FE analysis, nodal kinematics and element level deformation measures evolve through coupled node element updates. This motivates graph learned simulators that approximate one step FE state transitions and roll them out autoregressively. However, many mesh based graph surrogates are node centred, which makes element level variables and native nodal elemental exchange less direct to represent. This work proposes CAttBiGNN, a cross attention based bipartite graph neural network for coupled nodal elemental learning. The graph represents FE mesh nodes and elements as distinct entities linked by directed node element edges, enabling nodal displacement increments and element level deformation states to be predicted on their native discretisation domains. An edge aware cross attention processor uses geometric edge embeddings to modulate directional node element message passing. For larger graphs, CAttBiUGNN combines the bipartite processor with graph downsampling and upsampling to improve long-range information propagation. The method is evaluated on dome shaped cold forming and corner shaped hot forming benchmarks. Comparisons with node centred baselines and bipartite and attention ablations show improved accuracy and balance in nodal displacement and elemental thinning prediction during autoregressive rollout. The results indicate that the proposed finite element inspired learned simulator can support manufacturability oriented field prediction and efficient design space exploration in large deformation sheet material forming.

10.
medRxiv (Medicine) 2026-06-12

A Machine Learning Pipeline for Scalable Annotation of Patient-Ventilator Dyssynchrony from Bedside Ventilator Data

Objective: Patient-ventilator dyssynchrony (PVD) is a common and clinically consequential problem in critically ill patients receiving invasive mechanical ventilation. Yet automated identification of PVD subtypes at scale remains an unmet clinical need, owing to the lack of large annotated bedside waveform datasets. Methods: We developed and validated a semi-supervised algorithm for automated annotation of PVD. In two medical ICUs at a tertiary academic center, bedside devices continuously collected airway flow and pressure waveforms from the ventilators. We developed a software interface with an information retrieval system that grouped similar breaths for expert human review, yielding 1,542,296 labeled breaths across eight categories: 2 labels for breath delivery mode, 5 labels for PVD subtypes, and 1 label denoting a normal breath. Two pulmonary physicians with expertise in ventilator training and education provided the expert reference labels. We trained an initial classification model on a model-derivation set of 771,148 breaths (divided into training and validation) and evaluated it on a hold-out test set of 771,149 breaths A semi-supervised approach was utilized to extend labeling to an additional 12,965,000 unlabeled breaths. Results: The supervised model performed well across all labels, with Macro-F1 scores between 0.96 and 1.00. Semi-supervised learning across 12 rounds expanded the training set from 771,148 to 8,563,995 breaths without significant performance degradation. Conclusion: We developed a practical and scalable system for automated PVD annotation that performed well across all subtypes. This work provides a reproducible foundation for automated PVD labeling to support the development of machine-learning-based clinical decision support systems for identifying patient-level asynchrony.

11.
arXiv (CS.AI) 2026-06-15

From Shield to Target: Denial-of-Service Attacks on LLM-Based Agent Guardrails

arXiv:2606.14517v1 Announce Type: cross Abstract: LLM-based guardrails have emerged as a highly effective defense against prompt injection and jailbreak attacks in autonomous agents. However, we reveal that the very reasoning and task-following capabilities enabling this protection introduce a novel vulnerability: attackers can inject crafted data to trap the guardrail in extended reasoning loops, effectuating a systematic denial-of-service (DoS) attack. To systematically expose this threat, we design a beam-search optimization framework that crafts natural-language payloads to maximize guardrail reasoning length, utilizing an LLM proposer guided by a strategy bank. Based on the observation of guardrail's schema-following nature, we also provide another attack framework driven by mechanism-aware structural mutations with less computational load. The attack efficacy is systematically evaluated in two parts. First, in standalone evaluations, the attack generalizes across diverse guardrail architectures, safety templates, and agent benchmarks. Payloads optimized on a single open-source surrogate successfully transfer to eight leading model backbones (e.g., Claude, GPT, Gemini, DeepSeek, and Qwen), achieving a 13–63$\times$ token amplification. Second, in end-to-end real-world agent deployments (web, desktop, code, and multi-agent systems), the attack reveals up to a 148$\times$ latency amplification. We show that a single poisoned document can saturate shared guardrail infrastructures, effectively starving co-located agents and paralyzing the entire system. By uncovering this availability flaw, our work underscores the urgent need to develop cost-bounded, reasoning-robust guardrails.

12.
arXiv (CS.LG) 2026-06-16

ExpRL: Exploratory RL for LLM Mid-Training

arXiv:2606.17024v1 Announce Type: new Abstract: Sparse reward reinforcement learning (RL) has become a standard tool for improving LLM reasoning, but its success depends critically on the coverage present in the base model. In practice, models are often primed for RL through mid-training on curated reasoning traces that teach useful primitive skills such as decomposition, verification, or self-correction. Although effective, this strategy requires manually specifying what the model should learn, and it remains unclear whether such primitive coverage is enough for much harder problems, which require combining these skills into broader solution strategies. We study a more automated approach: RL-based mid-training using large corpora of human-written question-answer data. Rather than treating reference solutions as targets to imitate, our method, ExpRL, uses them as reward scaffolds: references are hidden from the policy and used only to construct problem-specific grading rubrics for judging on-policy reasoning traces. The policy samples from the original problem prompt, while an LLM judge compares the sampled reasoning trace against the reference solution and assigns outcome-level or process-level dense rewards. This lets ExpRL reinforce partial progress, useful intermediate reductions, and productive reasoning behaviors that sparse final-answer rewards often fail to upweight. On challenging math reasoning tasks, ExpRL yields stronger RL priming than SFT, sparse-reward GRPO, and self-distillation, and provides a better initialization for subsequent sparse-reward RL. Additional mixed-domain experiments further suggest that ExpRL can extend beyond the original math-only setting.

13.
arXiv (CS.LG) 2026-06-24

Neural Posterior Estimation of Terrain Parameters from Radar Sounder Data

arXiv:2605.08179v2 Announce Type: replace-cross Abstract: Radar sounders are electromagnetic instruments that can probe deep into the subsurface of Earth and other planetary bodies by processing the echo of transmitted radar waves. Conventional approaches for analyzing such data rely on approximate assumptions and often produce point estimates that ignore parameter correlations as well as galactic and measurement noise. We propose a simulation-based inference approach to terrain parameter inversion from radar sounder data, where synthetic observations from a GPU-based simulator are used to train a neural network-based density estimator for neural posterior estimation (NPE). By explicitly conditioning on reference surface assumptions, the proposed framework allows systematic evaluation of posterior robustness to reference surface variability. We demonstrate that our NPE model is well calibrated on simulated data and transferable to real Mars radar profiles, where we analyze terrain parameters using literature-informed reference values.

14.
arXiv (CS.AI) 2026-06-11

Intelligent Automation for Embodied Benchmark Construction: Pipelines, Embodiments, Simulators, and Trends

arXiv:2606.12207v1 Announce Type: cross Abstract: Embodied intelligence now spans navigation, household assistance, manipulation, autonomous driving, aerial agents, and multimodal large-model control. This expansion has made benchmark construction a central bottleneck for reliable evaluation. Unlike static datasets, embodied benchmarks combine task specifications, environments, robot data, demonstrations, annotations, metrics, evaluation scripts, and release policies into a single evaluation system. This survey reviews the literature through a five-stage construction pipeline: requirement and task construction, data acquisition, data cleaning and annotation, benchmark suite generation and metric definition, and evaluation execution with diagnostic feedback. For each stage, the survey analyzes the transition from manual curation to traditional automation, foundation-model assistance, and agentic closed-loop workflows. It also compares qualitative construction costs across human labor, data and asset acquisition, compute and simulation, validation and debugging, governance and maintenance, and rework risk. The main conclusion is that automation does not simply reduce benchmark cost. Instead, it often shifts cost toward validation, auditability, version control, and long-term governance. Progress in embodied evaluation will therefore depend not only on larger benchmark suites, but also on construction pipelines that are diagnosable, auditable, and responsibly refreshable.

15.
arXiv (CS.AI) 2026-06-11

Sparse probes and murky physics: a case study of interpretability challenges in a foundation model for continuum dynamics

arXiv:2606.11657v1 Announce Type: cross Abstract: Generative AI emulators are increasingly used in scientific domains where we already have strong theory, benchmarks, and physical intuition. This raises a central evaluation and interpretability question: when a foundation-style model can reproduce known continuum dynamics, what internal mechanism supports that behavior, is the internal behaviour consistent with known physics, and how does it relate to where the emulator succeeds or fails? We investigate a cross-domain foundation model for continuum dynamics, Walrus by Polymathic, using mechanistic interpretability guided by physical principles. We apply a sparse autoencoder (SAE) to probe a selected layer, and address the practical challenge of triaging a large feature set (over 20,000) using enstrophy as a physically grounded metric. As a deliberately simple testbed, we focus on shear flow and compare feature recruitment across multiple shear-flow setups, i.e. parameter values in the numerical simulation. Across setups we find evidence of piecewise consistency, with subsets of features recurring in similar roles, but this structure is intermittent and does not map cleanly onto standard physical decompositions. In parallel, direct comparisons between numerical simulation and the emulator reveal systematic output-level discrepancies, including regimes where energy/structures become too diffuse or too localized. We connect parts of these discrepancies to changes in specific SAE feature usage. Our work highlights open questions for scientific foundation models: how to robustly prioritize mechanistically meaningful features, how to separate stable structure from analysis artifacts (including single-layer and SAE limitations), and how to use established benchmarks to decide when "different" internal representations are genuinely informative rather than merely effective.

17.
arXiv (CS.AI) 2026-06-15

Large-scale semantic mapping of learner agency and autonomy reveals what measurement and generative AI research overlook

arXiv:2606.10881v2 Announce Type: replace Abstract: Learner agency and autonomy are foundational to personal development, yet a pervasive "jingle-jangle" fallacy (i.e. identical terms denoting different constructs, distinct terms denoting identical ones) has substantially hindered cumulative knowledge. Treating meaning as a phenomenon constituted through use in linguistic practice, we extracted 8,954 definitions and 2,700 scale items from over 14,000 publications, to investigate how researchers actually used learner agency and autonomy with a semantic analysis pipeline. The definitional landscape of two constructs resolves into three dimensions: regulation and control of learning (task), intrinsic motivation and internal decision-making (person), and social-relational action (sociocultural), thereby empirically quantifying the jingle-jangle fallacy. Existing scales, however, systematically underrepresent the sociocultural dimension. Critically, current generative AI research in education concentrates on learning regulation and control, narrowing the behavioral repertoire that AI-mediated learning environments are designed to cultivate. Beyond conceptual clarification, this work carries direct implications for conceptualization, measurement, and practice towards supporting the multidimensional learner agency and autonomy.

18.
arXiv (math.PR) 2026-06-16

Exponential Convengence of DLRA for SDEs

arXiv:2606.15843v1 Announce Type: new Abstract: We study dynamical orthogonal (DO) approximations of stochastic differential equations and investigate their long-time behaviour. The DO formulation represents the solution by a low-rank decomposition and leads to a coupled system consisting of an evolution equation on the Stiefel manifold and a reduced stochastic process. We establish the well-posedness of the strong DO system and derive quantitative error estimates between the original stochastic differential equation and its low-rank approximation in the Wasserstein distance. Our main contribution is the analysis of invariant probability measures for the DO dynamics. Under suitable dissipativity, Lipschitz continuity, and non-degeneracy assumptions on the coefficients, we prove the existence of an invariant probability measure for the strong DO system. The proof combines uniform moment estimates, a Krylov–Bogoliubov argument for an associated frozen system, and a Kakutani-Fan-Glicksberg fixed-point theorem to recover the self-consistent dynamics. We further show that the induced low-rank process admits an invariant probability measure and discuss the structure of invariant measures through several illustrative examples. These results provide a rigorous foundation for the use of dynamical low-rank approximations in the approximation of long-time statistical properties of stochastic dynamical systems.

19.
arXiv (CS.AI) 2026-06-25

GCT-MARL: Graph-Based Contrastive Transfer for Sample-Efficient Cooperative Multi-Agent Reinforcement Learning

arXiv:2606.25073v1 Announce Type: cross Abstract: In cooperative multi-agent reinforcement learning (MARL), from a deployment perspective, it is challenging and expensive to train agents from scratch for each new environment or task. In this work, we propose GCT-MARL, a transfer learning framework that builds on the multi-view graph contrastive backbone of MAIL and augments it with a per-view, adaptively weighted alignment loss and a two-phase training protocol specifically designed for transfer across populations of varying sizes and compositions. We empirically demonstrate that the proposed framework markedly accelerates convergence on the target task relative to from-scratch training, in both homogeneous (within-faction, varying N) and heterogeneous (cross-faction and mixed unit-type) transfer scenarios. Furthermore, we show that the framework naturally supports continual learning by sequentially chaining the two-phase transfer protocol across a series of related tasks. Overall, this work provides a unified approach to mitigating key limitations in current MARL transfer methods with new insights at both methodological and empirical levels.

20.
arXiv (quant-ph) 2026-06-24

Controlled Chaos in 4D SCFTs

arXiv:2606.23785v1 Announce Type: cross Abstract: Chaotic dynamics play an important role in a number of physical systems. One of the qualitative hallmarks of this behavior is the appearance of a sufficiently "complex" spectrum of energy levels. This also makes it challenging to directly verify the onset of chaos in interacting quantum field theories. We present a class of 4D superconformal field theories (SCFTs) given by orbifolds of 4D $\mathcal{N} = 4$ Super Yang–Mills theory in which operator mixing in a controlled subsector is described by an effective spin chain in one spatial dimension with nearest neighbor interactions tuned by the marginal couplings of the SCFT. Tuning the marginal couplings results in a chaotic spectrum, while generically the spin chain exhibits Anderson localization. We diagnose the onset of chaos by analyzing the statistical distribution of eigenvalues of the dilatation operator, in particular properties such as eigenvalue level repulsion, spectral rigidity, and the spectral form factor. We also show that other diagnostics such as Krylov complexity sometimes do not faithfully capture this information. This structure defines a chaotic billiard in the target space of the stringy realization. We also comment on the large $N$ holographic dual description, where the controlled single spin chain approximation must be supplemented by multi-trace dynamics, i.e., the splitting and joining of multiple spin chains.

21.
arXiv (CS.LG) 2026-06-25

Variational Autoencoder Layer

作者:

arXiv:2606.25900v1 Announce Type: new Abstract: Variational Autoencoders (VAEs) belong to a family of autoencoders with probabilistic properties, making them well suited for generating data by producing a smooth and continuous latent space. Despite being introduced over a decade ago, the method continues to be widely adopted in both research and industry for diverse applications. While VAEs are typically used as standalone models, this paper introduces a novel approach to integrate them as a neural network layer. Furthermore, a new training strategy is proposed for models incorporating these layers, and their performance is thoroughly analyzed.

22.
Nature Biotechnology 2026-06-19

Optimized R2 retroelement complexes for DNA insertion into plant genomes

Traditional approaches for DNA insertion into plant genomes using Agrobacterium tumefaciens result in random integration. Newer genetic engineering methods based on nucleases, prime editors, transposases and recombinases extend capabilities but remain constrained with low efficiencies, off-target integration or limited payload size. Here we adapt the avian Taeniopygia guttata R2 protein (R2Tg) for targeted DNA insertion into plant genomes by engineering R2Tg expression cassettes and RNA payloads carrying intron-disrupted reporters, with optimized ribosomal DNA homology arms and untranslated regions. In Arabidopsis thaliana protoplasts, Nicotiana benthamiana leaves and Solanum lycopersicum seedlings, our R2Tg editor system achieves targeted insertion of full-length payloads ranging from 2.2 kb to 5 kb. In Nicotiana benthamiana leaves, integration occurs, on average, at 1 copy per genome, which is 30 times more efficient than that achieved by Cas9 homology-directed repair. This work establishes an R2Tg ribonucleoprotein platform for targeted DNA insertion into plant genomes, using a multicopy genomic safe-harbor site to enable efficient addition of multikilobase genes. R2 retrotransposons are used to integrate DNA into plant and crop 25S ribosomal DNA sites.

23.
arXiv (CS.CV) 2026-06-25

Curvature-Guided Mixing for MLLM Adaptation

Fine-tuning Multimodal Large Language Models (MLLMs) on specialized tasks often leads to catastrophic forgetting of their general capabilities. Existing model merging methods to combat this are often heuristic or use sub-optimal objectives. We propose CurvatureGuided Mixing (CGM), a theoretically grounded framework that merges pre-trained and fine-tuned models. CGM formulates a joint optimization objective and uses a second-order (Hessian) approximation of the loss landscapes to analytically derive an optimal, closed-form "soft mixing" ratio. This ratio intelligently blends parameters based on their relative task-specific curvatures. We also introduce CGM$\dagger$, a robust "hard mixing" variant that performs sparse parameter selection guided by a novel, curvature-aware score. Experiments on LLaVA-1.5 and Qwen2.5VL across multiple downstream tasks show that CGM and CGM$\dagger$ consistently improve the trade-off between task specialization and general knowledge retention over existing methods. Code is available at github.com/zzsyjl/CGM-ECCV-2026.

24.
arXiv (CS.CV) 2026-06-12

Why Commodity WiFi Sensors Fail at Multi-Person Gait Identification: A Systematic Analysis Using ESP32

WiFi Channel State Information (CSI) has shown promise for single-person gait identification, raising interest in its use for contactless biometrics, continuous authentication, and passive identification. However, the feasibility of multi-person identification on low-cost commodity devices remains unclear. A critical question is whether weak multi-person performance is primarily an algorithmic limitation, or whether it reflects a more fundamental sensing ceiling on commodity WiFi hardware. We address this question through a systematic empirical study using commodity ESP32 WiFi sensors. We evaluated six different signal separation methods–FastICA, SOBI, PCA-ICA, NMF, Wavelet, and Tensor decomposition–across seven scenarios spanning 1-10 people in both controlled and realistic indoor environments. To investigate beyond classification accuracy, we introduce three diagnostic metrics: intra-subject variability (ISV), inter-subject distinguishability (ISD), and performance degradation rate (PDR). In all methods, performance remains moderate (39%-56% accuracy), with limited evidence that algorithmic choice alone solves the problem. The best-performing method, NMF, reaches 56% accuracy, while all methods exhibit extremely high feature-space overlap (97%-99%), unstable within-subject representations, and marked environmental sensitivity. These findings suggest that, under commodity ESP32 CSI constraints, dense multi-person gait identification is limited more by sensing quality and spatial diversity than by the chosen separation algorithm. Our results have direct implications for security and privacy: they call into question the practicality of commodity WiFi CSI as a robust multi-user biometric primitive for authentication, while also placing important bounds on the passive identification capabilities achievable with low-cost off-the-shelf WiFi hardware.

25.
arXiv (CS.CV) 2026-06-25

Reflective VLA: In-Context Action Consequences Make VLAs Generalize

Most vision-language-action (VLA) models are reactive: they predict the next action from the current instruction and observation, implicitly assuming that the current observation fully specifies the action-relevant state. In embodied control, however, embodiment-specific factors such as camera-to-robot geometry, robot calibration, or systematic actuation bias are often hard to identify from a single observation. As a result, reactive policies cannot reliably disambiguate these factors in general, overfitting to training environments and generalizing poorly at deployment. We propose Reflective VLA, which conditions each decision on a context of observation-action-consequence triplets. Each triplet records not only what the robot observed and executed, but also how the scene changed afterward, exposing the deployment-specific mapping from actions to observed effects. Architecturally, Reflective VLA routes all observation modalities through the VLM under shared attention, so the action expert reasons directly over past triplets and the current observation. A block-causal mask enables parallel multi-frame training without leakage and supports KV-cached real-time inference. On standard LIBERO and SimplerEnv-Bridge, Reflective VLA preserves strong in-distribution performance. Under distribution shift on LIBERO-Plus and the harder LIBERO-Plus-Hard, it improves average success rate by 5.4 and 4.2 percentage points over a matched reactive baseline. Ablations with a matched history-only baseline further show that action consequences – rather than additional context length alone – are the key to cross-environment generalization. Project page: https://lianqing11.github.io/reflective-vla-page/