探索全球前沿学术脉络

01.

Nature Biotechnology 2026-06-08 DOI: HASH:b326d2c206ff6337de3beeca09957a02

Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors

作者: 未知作者

We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients treated in phase 1 trials, SSP revealed marked spatial heterogeneity in antibody delivery and target engagement, which was shaped by conserved stromal barriers.

阅读与讨论 → 访问原文 →

02.

arXiv (CS.CL) 2026-06-24 DOI: arXiv:2606.24014

Reinforcement Learning Towards Broadly and Persistently Beneficial Models

作者:

Akshay V. Jagadeesh↗Rahul K. Arora↗Khaled Saab↗Ali Malik↗Mikhail Trofimov↗Foivos Tsimpourlas↗Johannes Heidecke↗Karan Singhal↗

As AI systems are deployed across increasingly diverse and high-stakes settings, model alignment must generalize beyond the tasks and domains seen during training. This is especially important for reinforcement learning (RL), which can introduce unexpected misalignment through reward hacking, deception, or other unintended strategies. We study whether RL on beneficial behavior, instantiated in realistic domains, can produce broad and persistent alignment generalization beyond the training distribution. We construct a dataset of realistic situations designed to measure and train beneficial traits, such as truthfulness, fairness, risk awareness, and corrigibility, spanning varied domains, including health, science, and education. We then train models with RL on this dataset and evaluate them on more than 50 independent benchmarks of alignment and beneficial behavior. Compared to a compute-matched baseline, beneficial trait RL improves performance on over 80% of these out-of-distribution benchmarks. We observe substantial out-of-distribution alignment transfer: a beneficial-behavior RL intervention entirely limited to one domain, health, produces broad improvements on non-health alignment evaluations, including reduced reward hacking, deception, and general misalignment. Finally, we study alignment persistence: whether behavior remains robustly aligned under attempts to steer models towards misalignment. Models trained with beneficial trait RL show improved persistence, including greater resistance to adversarial prompting and harmful finetuning; further work is required to isolate the sources of these effects. These results suggest that RL to reinforce beneficial behavior in realistic domains can produce models that are more robustly aligned with human flourishing.

阅读与讨论 → 访问原文 →

03.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.12386

ATLAS: Active Theory Learning for Automated Science

作者:

No\'emi \'Eltet\H{o}↗Nathaniel D. Daw↗Kimberly L. Stachenfeld↗Kevin J. Miller↗

arXiv:2606.12386v1 Announce Type: cross Abstract: Advancing scientific understanding through mechanistic modeling requires posing the right experimental questions to yield maximally informative data. To automate this pursuit within cognitive science, we introduce ATLAS (Active Theory Learning for Automated Science), an active learning framework for the data-driven discovery of interpretable behavioral models. ATLAS iterates between generating mechanistic hypotheses–instantiated as a diverse ensemble of sparse neural networks (Disentangled RNNs)–and designing experiments that optimally distinguish between them. We test this approach on the problem of recovering reinforcement learning agents from their behavior in bandit tasks. ATLAS designs varied sequences of qualitatively novel experiments with temporal structure tailored to underlying agent characteristics. The models trained on these experiments are evaluated against a comprehensive set of metrics for mechanistic modeling that capture behavioral, structural, and computational similarity. ATLAS achieves a 5-10x improvement in sample efficiency across all metrics compared to random experimentation, and its performance is further validated against expert-designed experiments derived from literature. These in silico results showcase ATLAS's potential to accelerate human-interpretable insights in cognitive science and other domains where scientific inquiry relies on discovering mechanistic models.

阅读与讨论 → 访问原文 →

04.

arXiv (CS.AI) 2026-06-12 DOI: arXiv:2606.12736

Benchmarking AI Agents for Addressing Scientific Challenges Across Scales

作者:

Tianyu Liu↗Allen Xin Wang↗Antonia Panescu↗Lisa Xinyi Chen↗Wenxin Long↗Xinyu Wei↗Yueqian Jing↗Ziyao Zeng↗Jihang Chen↗Sihan Jiang↗Ziqing Wang↗Siyi Gu↗…

arXiv:2606.12736v1 Announce Type: new Abstract: AI agents are increasingly being developed to accelerate scientific discovery, yet their practical capabilities in real research settings remain poorly understood. Existing benchmarks for AI agents rarely capture the complexity, heterogeneity, and extended reasoning required by scientific work, whereas benchmarks for scientific tasks often reduce research to static, direct problems and provide limited support for interactive evaluation. Here, we introduce SciAgentArena, a systematic benchmark for evaluating AI agents in real-world scientific research scenarios drawn from emerging needs across multiple domains. SciAgentArena comprises approximately 200 tasks with stepwise verification and an interactive, agent-agnostic environment for assessing diverse AI agents. Using this benchmark, we find that current agents can contribute effectively to well-specified data-analysis workflows, particularly when the task structure and evaluation criteria are clear. However, their performance remains uneven across scientific contexts: agents struggle to generate genuinely novel insights, sustain self-directed exploration, and formulate robust solutions for open-ended research questions. We further characterize common failure modes across agents and identify opportunities for improving their reliability, autonomy, and scientific reasoning. Together, SciAgentArena provides a practical framework for measuring progress in AI agents for science and for guiding the design of future agents capable of addressing complex scientific challenges. Full codes, tasks, and datasets can be accessed via this link: https://sciagentarena.github.io/.

阅读与讨论 → 访问原文 →

05.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.11632

Sovereign Assurance Boundary: Certificate-Bound Admission for Agentic Infrastructure

作者:

Jun He↗Deying Yu↗

arXiv:2606.11632v1 Announce Type: cross Abstract: Agentic infrastructure introduces a critical control-plane authorization problem: non-deterministic reasoning systems can propose high-stakes mutations to production resources, yet existing security mechanisms – such as identity and access management (IAM), policy engines, consensus protocols, and audit logs – either enforce static, context-unaware permissions or merely record actions post-execution. This paper introduces the Sovereign Assurance Boundary (SAB), a certificate-bound runtime admission layer for autonomous execution authority. SAB intercepts agent proposals at an assurance airlock, compiles them into typed execution contracts $C$, and binds these contracts to cryptographic evidence digests $H(E)$ and policy versions. The contracts are then routed through consequence-aware certification paths. Upon successful admission, the system emits a signed Sovereign Assurance Certificate ($\Omega$) that is strictly scoped to a specific execution identity, revocation epoch, and validity window. Finally, a sovereign execution broker verifies $\Omega$ and performs fresh pre-execution revocation and drift checks before invoking infrastructure APIs. We detail the airlock-broker architecture, formalize its admission and revocation invariants, and report preliminary feasibility measurements from a Go prototype evaluated over 2,500 admission attempts. Ultimately, this broker-enforced model prevents autonomous reasoning from directly mutating state, transforming delegated execution authority into a cryptographically verifiable, evidence-bound, revocable, and replayable runtime artifact.

阅读与讨论 → 访问原文 →

06.

arXiv (CS.CV) 2026-06-25 DOI: arXiv:2606.25437

LinStereo: Linear-Complexity Global Attention for Multi-Scale Iterative Stereo Matching

作者:

Yiran Wang↗Oliver Turner↗Viorela Ila↗

Existing Vision Foundation Model (VFM)-based iterative stereo pipelines under-exploit three information pathways: multi-scale backbone features are collapsed into single-level correlations, geometric priors remain untapped at initialization, and context propagates only locally. These gaps widen under degraded photometric cues, making underwater scenes a stringent generalization test. To address this, we propose LinStereo, built upon Depth Anything V3, whose core is a Position-Aware Linear Attention (PALA) module that replaces local recurrence with global aggregation at linear cost, propagating reliable estimates from well-matched regions into degraded areas while preserving disparity structure. PALA is made effective by two enabling components: Hierarchical Semantic Cost Volumes (HSCV), which supply scale-aligned correlations from the VFM feature hierarchy, and a Depth Prior Initialization (DPI) that converts monocular depth into a metrically calibrated warm start. LinStereo achieves state-of-the-art-level accuracy on standard benchmarks and strong cross-domain generalization, particularly on underwater scene where severe photometric degradation makes stereo matching particularly challenging, attaining the best overall accuracy with consistent gains 28% lower AbsRel on TartanAir-UW, 26% on SQUID, a real-world underwater dataset).

阅读与讨论 → 访问原文 →

07.

PLOS Computational Biology 2026-06-24 DOI: HASH:9be92ab037451935d495bf32ca57dd16

A new cancer progression model: From synthetic tumors to real data and back

作者:

Daniela Volpatto↗

by Daniela Volpatto, Sandro Gepiro Contaldo, Simone Pernice, Marco Beccuti, Francesca Cordero, Roberta Sirovich Intratumor heterogeneity (ITH) arises from the combined effects of genetic alterations, clonal interactions, and environmental constraints, and plays a central role in therapeutic resistance and disease progression. While ITH has been extensively documented in empirical tumor data, the scientific debate regarding the biological mechanisms underlying this heterogeneity remains complex, highlighting the need for cancer evolution models that are sufficiently flexible and sophisticated to reproduce the observed behaviors and to give insights on the unobserved ones. Here, we present a stochastic modelling framework for tumor evolution that integrates genotypic inheritance with phenotype driven functional traits and resource mediated competition. Mutational events are associated with functional capabilities such as altered proliferation, increased mutation rates, limit evasion potential or enhanced control over shared resources, allowing multiple genotypes to converge on similar phenotypes. The model explicitly tracks subclonal lineages while incorporating environmental constraints that modulate growth and competition. The framework is defined through a mathematically rigorous construction and is accompanied by an efficient simulation algorithm. To facilitate exploration and reproducibility, we provide an open-source graphical user interface that allows users to configure model parameters, run simulations, and inspect clonal genealogies and population dynamics without requiring direct interaction with the underlying code. Using this model, we illustrate how ecological feedbacks can shape clonal dynamics over time, supporting an interpretation in which early tumor growth is dominated by stochastic expansion, while later evolution increasingly reflects selection for traits that alleviate environmental constraints. Rather than constituting a new evolutionary paradigm, this behaviour demonstrates how well-documented biological patterns can emerge naturally from a unified stochastic and ecological description. Overall, our approach offers a flexible and extensible platform for investigating how chance, functional traits, and environmental interactions jointly govern tumor heterogeneity.

阅读与讨论 → 访问原文 →

08.

arXiv (CS.CV) 2026-06-24 DOI: arXiv:2606.24297

Training-free Cross-domain Few-shot Segmentation via Robust Semantic Representation and Matching

作者:

Sujun Sun↗Mingwu Ren↗Haofeng Zhang↗

Cross-domain Few-shot Segmentation (CD-FSS) aims to transfer knowledge learned from source domain to distinct target domains, segmenting unseen target classes with only a few annotated samples. Although existing methods have made significant progress, they still rely on training or fine-tuning processes, which incur high computational costs and risk overfitting. We observe that when powerful and general-purpose vision foundation models are incorporated into these methods, their performance shows only marginal improvement or even degrades due to overfitting. To address this, we eliminate trainable parameters and propose a training-free framework to avoid both training overhead and overfitting. Built upon the self-supervised vision encoder DINOv3, our framework addresses cross-domain challenges through three core modules. First, the Semantic-aware Feature Re-fusion (SAFR) module identifies and re-fuses features that emphasize semantic patterns, generating representations with enhanced semantic discriminability. Additionally, the Adaptive Support Enhancement (ASE) module narrows semantic gaps between support and query through robust query information aggregation. Finally, the Hybrid Prototype Matching (HPM) module integrates matching results from diverse prototypes to adapt to varying semantic complexity across domains. Extensive experiments on four target domain datasets demonstrate that our method achieves state-of-the-art performance in CD-FSS without any training.

阅读与讨论 → 访问原文 →

09.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2605.10592

A Resilient Solution for Sewer Overflow Monitoring across Cloud and Edge

作者:

Vipin Singh↗Tianheng Ling↗Peter Ghaly↗Felix Grimmeisen↗Gregor Schiele↗Felix Biessmann↗

arXiv:2605.10592v2 Announce Type: replace Abstract: Aging combined sewer systems in many historical cities are increasingly stressed by extreme rainfall events, which can trigger combined sewer overflows (CSO) with significant environmental and public health impacts. Forecasting the filling dynamics of overflow basins is critical for anticipating capacity exceedance and enabling timely preventive actions for CSO. We present a web-based demonstrator that integrates Deep Learning forecasting methods in both cloud and edge settings into an interactive monitoring dashboard for overflow monitoring, resilient to network outages. A video showcase is available online (https://cloud.bht-berlin.de/index.php/s/b9xt4T3SdiLBiFZ).

阅读与讨论 → 访问原文 →

10.

arXiv (CS.AI) 2026-06-15 DOI: arXiv:2605.07984

Where's the Plan? Locating Latent Planning in Language Models with Lightweight Mechanistic Interventions

作者:

Nicole Ma↗Nick Rui↗

arXiv:2605.07984v2 Announce Type: replace-cross Abstract: We study planning site formation in language models – where internal representations of structurally-constrained future tokens form during the forward pass, and whether they causally drive generation. Using rhyming-couplet completion as a clean test of forward-looking constraint, we apply two lightweight methods (linear probing and activation patching) across Qwen3, Gemma-3, and Llama-3 at more than ten scales. Probing shows that future-rhyme information is linearly decodable at the line boundary, with signal that strengthens with scale in all three families. Activation patching reveals that only Gemma-3-27B causally relies on this encoding, exhibiting a handoff in which the causal driver migrates from the rhyme word to the line boundary around layer 30. Every other model we test conditions on the rhyme word throughout generation, with near-zero causal effect at the line boundary despite strong probe signal. We localize the Gemma-3-27B handoff to five attention heads through two-stage path patching that recover ~90% of the rhyme-routing capacity at the newline.

阅读与讨论 → 访问原文 →

11.

arXiv (CS.CV) 2026-06-18 DOI: arXiv:2606.18675

BrainFusionNet: a deep learning and XAI model to understand local, global, and sequential features of MRI images for improved brain tumour detection

作者:

Md Taimur Ahad↗Bo Song↗Yan Li↗

The noise of Magnetic Resonance Imaging MRI poses challenges for Deep Learning DL when tumor boundaries are obscured tumor location and appearance are complex Therefore we develop BrainFusionNet that combines Convolutional Neural Networks CNNs Vision Transformers ViT and Gated Recurrent Units GRUs to extract spatial contextual and sequential features from MRI images for improved brain tumor classification Furthermore explainable AI such as SHAP LIME and GradCAM are integrated to visualise and highlight image regions that contribute to BrainFusionNets decisionmaking process The proposed BrainFusionNet model is evaluated on two publicly available MRI datasets Kfold validation suggests 98 accuracy on both datasets The model was compared with the six stateoftheart SOTA CNNs and transfer learning Among the SOTA CNNs DenseNet121 and VGG16 achieved the highest accuracy of 96 The novelty of BrainFusionNet is that the hybrid model effectively extracts local and global features from MRI images even in smallscale tumor regions and small tumor sizes The model has a balanced sequential CNN architecture to capture lowlevel and deeperlayer features a customized ViT that captures local features stabilizes gradient flow and reduces the risk of vanishing gradients during MRI image training The CNN and ViT outputs are fed into a GRU for final classification Furthermore we analyze pixel intensities to determine whether MRI image quality affects image classification Our findings are very novel in image interpretation as we found that the distribution of pixel intensities in MRI images affects DL performance

阅读与讨论 → 访问原文 →

12.

arXiv (quant-ph) 2026-06-19 DOI: arXiv:2606.20281

Arrival times of an atomic Bose-Einstein condensate

作者:

Pascal Naidon↗Lucas Happ↗Denis Boiron↗

arXiv:2606.20281v1 Announce Type: cross Abstract: The times of flight of an atomic Bose-Einstein condensate are theoretically investigated in the experimentally unexplored regime corresponding to detection close to the trap of the condensate. In this regime, there is no consensus on how to calculate the distribution of times of arrival onto the detector. For non-interacting particles, distinct theoretical predictions have been made in the past. This work analyses how these predictions are modified for an interacting Bose-Einstein condensate. For this purpose, a time-dependent Gross-Pitaevskii equation is solved analytically and numerically.

阅读与讨论 → 访问原文 →

13.

arXiv (CS.LG) 2026-06-16 DOI: arXiv:2606.11123

Overcoming Rank Collapse in Feedback Alignment

作者:

Gauthier Boeshertz↗Razvan Pascanu↗Claudia Clopath↗

arXiv:2606.11123v2 Announce Type: replace Abstract: Backpropagation (BP) is widely viewed as biologically implausible, in part because it requires feedback weights to be the transpose of forward weights for error propagation. Interestingly, when training a network with fixed random feedback weights to circumvent this issue, learning aligns the forward weights with the feedback weights, leading the backpropagated error signal to become an approximation of the standard gradient used by BP. This process, called Feedback Alignment (FA), occurs in MLPs and very shallow CNNs but does not scale well to deeper architectures. In this work, we first investigated differences between BP and FA models, trained on CIFAR10, specifically focusing on the effective rank of the signal. We found that the FA error has a considerably lower rank and hence is constrained to a lower-dimensional subspace compared to BP, limiting exploration of the parameter space. Motivated by this observation, we evaluated two mechanisms for increasing the effective dimensionality of FA: Muon, an optimiser that orthogonalises weight updates; and hidden activity normalisation, which promotes activation orthogonality. Across larger architectures and benchmarks, we find that these methods consistently improve over FA baselines, for example, on CIFAR100 with a Resnet-18, accuracy increases by 9 percentage points. Our results identify low-dimensional gradient dynamics as a key obstacle to scaling FA and suggest that inducing higher-dimensional update geometry is a promising route toward scaling alternatives to backpropagation.

阅读与讨论 → 访问原文 →

14.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.11262

PermDoRA – Understanding Adapter Interference in Language Models: Limits of Parameter-Space Geometry

作者:

Gowtham Sivaramakrishnan↗Sarvesha Kumar Kombaiah Seetha↗Kishan Gupta Balaji↗Santhosh Baradwaj Vaduvur Ranganathan↗

arXiv:2606.11262v1 Announce Type: cross Abstract: Access control in large language models (LLMs) requires modular mechanisms to enable domain-specific behavior without retraining or cross-domain interference. A common hypothesis is that interference during adapter composition arises from overlap in linear parameter updates, suggesting that enforcing orthogonality or directional independence should improve multi-domain performance. We test this hypothesis using DoRA-RBAC, a hierarchical adapter composition framework based on weight-decomposed low-rank adaptation. We compare conventional Euclidean merging with a geometry-aware Riemannian-inspired merging strategy that approximates the Frechet mean via normalized directional averaging across multiple QA benchmarks (GPQA, PubMedQA, SimpleQA, WMDP) on LLaMA-3.1-8B and Mistral-7B. Our results show that while single-domain performance matches LoRA, geometry-aware merging provides no consistent advantage over standard averaging in multi-domain settings.Diagnostic analysis further reveals that angular alignment and orthogonality of adapter updates are weak predictors of composition performance. These findings suggest that adapter interference is not governed primarily by parameter-space geometry, but is instead consistent with interactions in shared nonlinear representations.

阅读与讨论 → 访问原文 →

15.

arXiv (CS.CL) 2026-06-15 DOI: arXiv:2606.13683

UP-NRPA: User Portrait based Nested Rollout Policy Adaptation for Planning with Large Language Models in Goal-oriented Dialogue Systems

作者:

Hui Wang↗Fafa Zhang↗Meng Liu↗Xiangyu Chen↗Chaoxu Mu↗

To address the challenge that current dialogue policy planning methods struggle to dynamically adapt to diverse user characteristics, this paper proposes a User Portrait based Nested Rollout Policy Adaptation (UP-NRPA) online framework with Large Language Models. In contrast to conventional approaches dependent on model training and require offline reinforcement learning policy models for user groups, UP-NRPA enables dynamic customization of dialogue strategies through an adaptive mechanism. This is achieved by leveraging real-time user feedback alongside personality, preferences, and objectives mapped from the current user portrait, thereby adapting to user characteristics without offline reinforcement learning. In collaborative and non-collaborative dialogue benchmarks, UP-NRPA demonstrated considerable benefits, achieving an impressive 100% success rate in multiple dialogue tasks. Particularly in negotiation tasks, the sale-to-list ratio (SL) increased by 56.41%. This demonstrates that UP-NRPA can adapt to diverse user needs without requiring a training mechanism, enabling the dialogue system to adapt to user characteristics.

阅读与讨论 → 访问原文 →

16.

arXiv (CS.LG) 2026-06-24 DOI: arXiv:2602.22810

Multi-agent imitation learning with function approximation: Linear Markov games and beyond

作者:

Luca Viano↗Till Freihaut↗Emanuele Nevali↗Volkan Cevher↗Matthieu Geist↗Giorgia Ramponi↗

arXiv:2602.22810v2 Announce Type: replace Abstract: In this work, we present the first theoretical analysis of multi-agent imitation learning (MAIL) in linear Markov games where both the transition dynamics and each agent's reward function are linear in some given features. We demonstrate that by leveraging this structure, it is possible to replace the state-action level "all policy deviation concentrability coefficient" (Freihaut et al., arXiv:2510.09325) with a concentrability coefficient defined at the feature level which can be much smaller than the state-action analog when the features are informative about states' similarity. Furthermore, to circumvent the need for any concentrability coefficient, we turn to the interactive setting. We provide the first, computationally efficient, interactive MAIL algorithm for linear Markov games and show that its sample complexity depends only on the dimension of the feature map $d$. Building on these theoretical findings, we propose a deep MAIL interactive algorithm which clearly outperforms BC on games such as Tic-Tac-Toe and Connect4.

阅读与讨论 → 访问原文 →

17.

bioRxiv (Bioinfo) 2026-06-22 DOI: HASH:155baf23fd9ef7ce2e8334dbb1ec475c

Few-Shot Classification of C. elegans Developmental Stages via Explainable Hierarchical Hyperbolic Graph Embeddings

作者:

Khalid↗Elliott↗Obafemi-Ajayi↗Wunsch↗Scharf↗

Automated, accurate, and fast developmental-stage classification of C. elegans from microscopy-based morphological images is essential for aging research, drug screening, and disease modeling. However, it remains challenging due to morphological similarities between stages and the limited annotated data. In this work, we propose HyperDev, a hyperbolic few-shot learning framework that addresses these limitations by directly encoding developmental hierarchies in the embedding space, unlike conventional Euclidean approaches that treat stages as independent classes. HyperDev uses Poincare ball geometry, combined with a biologically informed developmental prior, to naturally represent stage relationships. We introduce our selfcurated C. elegans dataset spanning seven developmental stages (Egg, L1-L4, Adult, Dauer) with extreme class imbalance (6-8 samples per minority class). HyperDev achieves competitive classification accuracy (76.9-88.3%) while providing intrinsic explainability across nine 7-way few-shot evaluation settings. The learned embeddings exhibited strong biological alignment (Pearson r = 0.669, p < 0.001), while significantly outperforming ProtoNet (r = 0.187), MatchingNet (r = 0.235), and RelationNet (r = 0.464). These results establish hyperbolic geometry as a principled approach to explainable few-shot learning in biological imaging, where understanding learned representations is as critical as predictive performance. Clinical Relevance–By enabling explainable, data-efficient developmental staging from scarce samples, HyperDev supports improved phenotype quantification for aging research, disease modeling, and drug screening. Index Terms–Hyperbolic learning, few-shot classification, developmental staging, Caenorhabditis elegans, interpretability, explainability.

阅读与讨论 → 访问原文 →

18.

arXiv (quant-ph) 2026-06-17 DOI: arXiv:2606.17877

Frequency upconversion of infrared signals via molecular cavity optomechanical systems with gain

作者:

Shu-Xian Quan↗Fen Zou↗Yong Li↗

arXiv:2606.17877v1 Announce Type: new Abstract: Molecular cavity optomechanical systems have recently emerged as a promising platform for enhancing infrared detection sensitivity, owing to their ability to up-convert low-frequency infrared (IR) photons to visible frequency range. Generally, under red-detuned pumping in such systems, the ideal conversion efficiency of the IR signal approaches 1. To overcome this efficiency constraint, we propose a scheme that incorporates gain into the infrared cavity of a molecular cavity optomechanical system comprising two cavities and an ensemble of N molecules. The upconversion process, which relies on IR absorption and Raman scattering associated with specific vibrational modes, is significantly amplified by the incorporation of gain under the red-detuned conditions. Moreover, our analysis demonstrates that the added noise is maintained near 0.5.

阅读与讨论 → 访问原文 →

19.

arXiv (math.PR) 2026-06-15 DOI: arXiv:2603.29047

Longest weakly increasing subsequences of discrete random walks on the integers with heavy tailed distribution of increments

作者:

Jos\'e Ricardo G. Mendon\c{c}a↗Marcelo V. Freire↗

arXiv:2603.29047v2 Announce Type: replace-cross Abstract: We investigate the behavior of the length of the longest weakly increasing subsequences (weak LIS) of $n$-step random walks with nonzero integer increments $k = \pm 1, \pm 2, \dots$ given by a symmetric heavy tailed mass distribution proportional to $|k|^{-1-\alpha}$ for several values of the real parameter $\alpha > 0$ together with that of the simple random walk ($k=\pm 1$), to which the $n$-step heavy tailed walks reduce when $\alpha$ grows large enough that step jumps beyond $\pm 1$ become essentially absent on the scale of $n$. By means of exploratory fits, weighted nonlinear least squares, and nested-model comparisons, we found that the sample average length $\langle{L_{n}}\rangle$ scales like $\langle{L_{n}}\rangle \sim \sqrt{n}\log{n}$ when the distribution of increments has finite variance ($\alpha > 2$) and $\langle{L_{n}}\rangle \sim n^{\theta}$ with a varying exponent $\theta > 0.5$ when the variance is infinite ($\alpha \leq 2$). Distributional diagnostics indicate that the bulk of the $L_{n}$ distribution is very well-approximated by a lognormal model, though systematic deviations are observed in the tails. Our results corroborate and expand upon previous results for the LIS of other types of heavy-tailed random walks and raise a conjecture as to whether the distribution of $L_{n}$ is given, or can be effectively described, by a lognormal distribution.

阅读与讨论 → 访问原文 →

20.

arXiv (CS.AI) 2026-06-16 DOI: arXiv:2606.15096

VGPT-RSI for RH-Adjacent Formal Progress: Boundary Certificates, Verified Finite Lagarias Inequalities, and Explicit Failure Localization

作者:

Zhixin Hu↗Tao Xu↗Xiaodian Sun↗Li Jin↗Momiao Xiong↗

arXiv:2606.15096v1 Announce Type: new Abstract: The Riemann Hypothesis remains one of the central unsolved problems in mathematics. Rather than claiming proof, we investigate whether a verifiable AI-assisted reasoning system can produce reliable, formally checked partial progress while explicitly identifying the remaining mathematical obstructions. We apply the Verifiable Growing Physical Transformer with Recursive Self-Improvement (VGPT-RSI) to two RH-adjacent certification tasks. First, we construct and verify a finite RH-boundary certificate for inequality on a parameterized safe lower curve over a region. The numerical boundary curve is converted into a certificate-backed lower curve, audited using outward-rounded interval arithmetic and Arb/FLINT ball arithmetic, and then checked in Rocq/CoqInterval for the parameterized theorem. Second, we initiate a formal Lagarias-route certificate. Lagarias criterion states that RH is equivalent to the global inequality. We formalize the finite quantity and produce a Coq-checked finite certificate. The final system identifies the exact unresolved mathematical bottlenecks: formalizing the Lagarias equivalence, proving the global tail theorem beyond any finite cutoff, and potentially reducing counterexamples to colossally abundant or related extremal integers. These results demonstrate that VGPT-RSI can produce certified RH-adjacent formal progress, organize proof dependencies, and avoid overclaiming when the remaining obstruction is genuinely mathematical.

阅读与讨论 → 访问原文 →

21.

arXiv (CS.CV) 2026-06-24 DOI: arXiv:2606.24330

REDI-Match: Rotation-Equivariant Distillation for Efficient and Robust Dense Matching

作者:

Yinji Ge↗Guixu Zheng↗Wulong Guo↗Qian Feng↗Xu Wu↗Kai Zhou↗Xinyuan Liu↗Fei Xing↗

Vision Foundation Models (VFMs) have significantly advanced dense feature matching, yet severe in-plane rotation remains a critical challenge. Existing solutions face a fundamental dilemma: data-driven methods require inefficient parameter scaling to implicitly learn rotations, whereas strictly equivariant networks lack the semantic capacity of modern VFMs. Consequently, current frameworks typically freeze VFMs and shift the entire burden of rotation generalization to the downstream decoder. To break this architectural bottleneck, we propose REDI-Match, an efficient framework driven by a novel Rotation-Equivariant Distillation (REDI) paradigm. Instead of relying on rotation data augmentation to establish rotational correspondences, REDI distills the non-equivariant semantic representations of a VFM into a lightweight, strictly rotation-equivariant encoder, leveraging an equivariant geometric architecture to constrain robust high-dimensional semantics. To fully exploit these features, we equip the decoder with an entropy-driven spatial alignment module. By evaluating discrete rotation hypotheses, this mechanism explicitly locks onto the canonical coordinate system, eliminating global ambiguity before continuous refinement. Extensive experiments demonstrate that REDI-Match establishes a new state-of-the-art (SOTA) across multiple benchmarks. Notably, it achieves a 13.89% absolute pose accuracy improvement on the highly challenging SatAst dataset while operating 1.9x faster than the current SOTA (RoMa v2), enabling real-time inference (~41 FPS) on a single RTX 4090 GPU. Code: https://github.com/YinjiGe/REDI-Match.

阅读与讨论 → 访问原文 →

22.

medRxiv (Medicine) 2026-06-15 DOI: HASH:266b3d0161a06b994fc62243b3890604

Wellbeing After Stroke-2 (WAterS-2): a feasibility study with process evaluation exploring inclusive, accessible, online psychological support after stroke

作者:

Longley↗Woodward-Nutt↗Cotterill↗Chouliaria↗Thomas↗Bamford↗Bowen↗Patchwood↗

Objectives: Explore feasibility and acceptability of upskilling a workforce to deliver a co-developed intervention, based on Acceptance and Commitment Therapy (ACT), to support psychological adjustment post-stroke targeting underserved groups. Design: Multi-site, single-arm feasibility study with embedded mixed-methods process evaluation (ISRCTN17628580). Setting: Four NHS community stroke services across England. Participants: 1. Stroke survivors [&ge;]18 years of age, [&ge;]4 months post-stroke, reporting psychological difficulties adjusting to stroke, able to consent and access remote group sessions in English; 2. Group facilitators from NHS stroke services, not ACT specialists. Intervention: WAterS-2: an eight-session, remotely-delivered ACT-informed group intervention. Outcome measures: Recruitment, fidelity, safety, acceptability and perceived value were assessed using fidelity checklists, post-intervention surveys and semi-structured interviews with stroke survivors and facilitators. Clinical outcomes including mood (HADS), wellbeing (ONS4), psychological flexibility (AAQ-ABI), measured post-group and three-months later. Results: Nineteen stroke survivors recruited (mean 9.6 months post-stroke; n=5 (26%) minoritised ethnicities; n=10 (52%) with aphasia). Thirteen facilitators - including two peer support workers - delivered the intervention with fidelity following structured training across four services. Drop-out was low (2/19; 11%); with 15 (79%) attending [&ge;]5/8 sessions. Remote data collection was feasible (79% follow-up completion), with no adverse events recorded. Acceptability was high: survivors valued peer connection, grounding and mindfulness practices. ACT metaphors were helpful for some but challenging for others, including some with aphasia. Online delivery was suitable but limited informal connection. Facilitators reported increased capability, incorporating ACT skills into routine care. NHS workforce pressures and geographically-constrained referral pathways limited recruitment reach. Conclusions: WAterS-2 is feasible, safe, acceptable and inclusive. A mixed workforce, including NHS peer support workers, can be upskilled to deliver with fidelity. Inclusion of underserved groups is achievable but requires active strategies beyond standard NHS referral routes. Findings inform a provisional logic model and a future pragmatic trial.

阅读与讨论 → 访问原文 →

23.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2512.24838

CropTrack: A Tracking with Re-Identification Framework for Precision Agriculture

作者:

Md Ahmed Al Muzaddid↗Jordan A. James↗William J. Beksi↗

Multiple-object tracking (MOT) in agricultural environments presents major challenges due to repetitive patterns, similar object appearances, sudden illumination changes, and frequent occlusions. Contemporary trackers in this domain rely on the motion of objects rather than appearance for association. Nevertheless, they struggle to maintain object identities when targets undergo frequent and strong occlusions. The high similarity of object appearances makes integrating appearance-based association nontrivial for agricultural scenarios. To solve this problem we propose CropTrack, a novel MOT framework based on the combination of appearance and motion information. CropTrack integrates a reranking-enhanced appearance association, a one-to-many association with appearance-based conflict resolution strategy, and an exponential moving average prototype feature bank to improve appearance-based association. Evaluated on publicly available agricultural MOT datasets, CropTrack demonstrates consistent identity preservation, outperforming traditional motion-based tracking methods. Compared to the state of the art, CropTrack achieves significant gains in association accuracy and identification precision scores with a lower number of identity switches.

阅读与讨论 → 访问原文 →

24.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.11794

Multimodal Ordinal Modeling of Alzheimer's Disease Severity Using Structural MRI and Clinical Data

作者:

Boris-Stephan Rauchmann↗Jonathan Laib↗Buse Ercik↗Robert Perneczky↗Sergio Altares-L\'opez↗

arXiv:2606.11794v1 Announce Type: cross Abstract: Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability. We propose an attention-enhanced multimodal machine learning framework with ordinal regression for automated and interpretable AD severity staging. The framework integrates T1-weighted MRI with demographic and genetic variables and compares unimodal and multimodal architectures using ordinal and non-ordinal prediction heads. Models were trained and validated using cohort-stratified splits derived from the ADNI, AIBL, and NIFD datasets. A strictly held-out test set was constructed using subjects excluded from all training, validation, preprocessing, and hyperparameter tuning procedures, with subject-level splitting employed throughout to prevent data leakage. Among unimodal approaches, the T1-weighted MRI model achieved slightly higher adjacent-stage accuracy (0.963) and agreement with clinical staging (QWK 0.444) than the tabular model (QWK 0.433). Integrating imaging, demographic, and genetic information improved overall performance. The multimodal non-ordinal baseline achieved the lowest prediction error (MAE 0.340), whereas the ordinal multimodal model achieved the highest adjacent-stage accuracy (0.970) and strongest agreement with clinical staging (QWK 0.549). These findings indicate that ordinal formulations better capture the ordered structure of the CDR scale and yield predictions more consistent with clinical staging. Explainability analyses using Grad CAM++ and SHAP demonstrated anatomically and clinically plausible model behavior, supporting transparent decision-making. Overall, attention-based multimodal learning with ordinal regression represents a robust, interpretable, and scalable approach for automated AD severity staging and AI-assisted clinical decision support.

阅读与讨论 → 访问原文 →

25.

arXiv (CS.AI) 2026-06-19 DOI: arXiv:2606.20216

Learner-based Concept Drift Detection: Analysis and Evaluation

作者:

Md Moman Ul Haque Khan↗Samira Sadaoui↗

arXiv:2606.20216v1 Announce Type: cross Abstract: Machine learning algorithms deployed for evolving streaming environments must handle the non-stationary data distributions, commonly referred to as concept drift. The presence of concept drift poses a major challenge for many real-world applications because it can severely degrade their predictive performance, hindering their ability to support robust decision-making. Consequently, the timely and efficient detection of drift events is critical for sustaining high accuracy over time. This study examines theoretically the concept drift characteristics and numerous drift detection algorithms across several categories. Furthermore, we evaluate their performance on both synthetic and real-world datasets exhibiting diverse streaming scenarios and drift characteristics, such as abrupt and gradual changes. This study aims to enhance understanding of the complex notion of concept drift characteristics and behavior of drift detectors, along with their applicability to diverse contexts.

阅读与讨论 → 访问原文 →