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01.

medRxiv (Medicine) 2026-06-24 DOI: HASH:be2bde9b264fdf32366c6f97e392243d

Rapid-Response Viral Genome Detection using TWIST Capture and Nanopore Flongle Sequencing

作者:

Rector↗Bloemen↗Swinnen↗Karatas↗De Coninck↗Matthijnssens↗Van Ranst↗Wollants↗

Background: Rapid detection of viral pathogens can be challenging, especially when routine PCR fails. Conventional assays typically detect known viruses which are specifically targeted by the assay, which may result in the failure to identify novel or non-targeted viruses. Broad-range hybrid-capture sequencing enables unbiased detection of viruses, including those that are uncommon or divergent. Methods: We combined the TWIST Comprehensive Viral Research Panel (>3,000 virus species) with Oxford Nanopore Flongle sequencing for easy and quick viral genome detection. The workflow includes random-primed cDNA synthesis, dsDNA conversion, TWIST probe enrichment, and Nanopore sequencing. Performance was evaluated using the QCMD 2024 Viral Metagenomics EQA panel and one clinical sample. Results: All expected targets of the QCMD 2024 Viral Metagenomics EQA panel were detected; eight of thirteen viruses achieved [≥]90% genome coverage. The negative control showed no targeted viral reads. Mixed infections of DNA and RNA viruses were resolved accurately. The workflow from nucleic acid extraction to obtaining sequence data was completed within 3 days.

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02.

bioRxiv (Bioinfo) 2026-06-11 DOI: HASH:2d3d07497b09a182ddd785e1b46d0e82

HalluDesign-NA: Extending HalluDesign for De Novo Nucleic Acid Design

作者:

Fang↗Wang↗Cao↗

AlphaFold3 has revolutionized the prediction of biomolecular structures and interactions, including atomic-level modeling of nucleic acids. However, the de novo design of structured and functional nucleic acids remains a significant challenge. Here, we extend our HalluDesign framework to nucleic acid design by integrating NA-MPNN for nucleic acid sequence optimization and design. This new framework, HalluDesign-NA, enables iterative sequence-structure co-optimization, facilitating the de novo design of nucleic acids. Computational benchmarking across ssDNA, ssRNA, and aptamer design tasks demonstrates consistent improvements in confidence scores (pLDDT, ipTM), supporting the feasibility of de novo nucleic acid design under various constraints, such as sequence length, symmetry, and protein structure context. We anticipate that HalluDesign-NA will accelerate the de novo design of functional nucleic acids for applications in biotechnology and medicine. The source code for HalluDesign-NA is available at https://github.com/MinchaoFang/HalluDesign_NA.

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03.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2606.14723

Disagreement-Based Cross-Model Routing for Implicit Video Question Answering

作者:

Durga Sandeep Saluru↗

We study multiple-choice video question answering on the ImplicitQA benchmark, where the correct answer is never explicitly shown but must be inferred from off-screen events, line-of-sight cues, causal structure, and cross-shot spatial layout. On this benchmark a single frontier video LLM already operates near its accuracy ceiling, and we observe that conventional self-consistency strategies – majority voting across repeated samples of the same model – can hurt rather than help, because the model's errors on hard questions are correlated. We propose disagreement-based cross-model routing, a pure inference-time procedure that requires no labels and no training. We triple-sample a native-video model (Gemini 3.1 Pro Preview) at temperature zero, exploit the genuine sample-to-sample variance of its video-processing pipeline to identify the roughly 20% subset of questions where the three samples disagree, and route only that subset to a second model from a different family (Claude Opus 4.8) that consumes uniformly sampled frames with adaptive thinking. On the 1001-question validation set with public ground truth – our main evaluation – the method improves AvgAcc by +1.43 over the best single sample of the primary model, with per-category gains concentrated on Motion & Trajectory (+5.49), Inferred Counting (+3.45), and Vertical Spatial Reasoning (+1.82) – the categories most dependent on cross-shot reference resolution. The same pipeline applied to the held-out 172-question CVPR 2026 ImplicitQA challenge test set achieves 82.03 AvgAcc / 79.71 MacroAvgAcc (+1.81 over the best single sample of the primary model), confirming the validation result on an independent split.

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04.

arXiv (CS.LG) 2026-06-11 DOI: arXiv:2606.11266

Seeing Before Colliding: Anticipatory Safe RL with Frozen Vision-Language Models

作者:

Samuel Tetteh↗Cody Fleming↗

arXiv:2606.11266v1 Announce Type: new Abstract: The cost signal that constrained-RL algorithms optimize against is almost always reactive: the simulator emits a non-zero cost only after a collision has begun, and the Lagrange multiplier of PPO-Lagrangian grows only after the episode budget has been exceeded. At race speeds, where collisions are instantaneous and irreversible, any safety mechanism that waits for cost to accumulate is structurally too late. We present VLM-Safe-RL, a framework that integrates a frozen vision-language model into the CMDP Lagrangian update as an anticipatory cost term. The framework comprises four contributions: (i) Decoupled Dual-Path CLIP, independent reward/cost paths that respect the CMDP's factorization; (ii) VLM-Lagrange, an augmented multiplier update that incorporates a per-step VLM cost as an anticipatory term; (iii) Confidence Gating, a Bayes-optimal weight derived from a logistic noise model on the CLIP margin; and (iv) VLMPPOLag, the composed algorithm. On Safety-Gymnasium FormulaOne L2, our principal evaluation ($n{=}5$ seeds, $10^{6}$ steps, budget $d_{lim}{=}25$) VLMPPOLag$+$Conf is the only configuration in our default budget comparison that simultaneously retains substantive return ($J_r{\approx}40$) and holds cost within budget on a majority of seeds; the five constraint-aware baselines (PPOLag, CPO, CPPOPID, CPO-CLG, PPOLag-RND) each fail at least one requirement. The mechanism generalizes to held-out MetaDrive Medium (catastrophe rate $41\%{\to}26\%$, 95\% bootstrap CI $[-26,-5]$\,pp) and shows directionally consistent transfer to Bullet Safety-Gym; we report honestly where it does not (MetaDrive Easy/Hard, Qwen2-VL backbone) and trace the Hard failure to a Lagrangian-regulation pathology rather than the VLM signal itself. To our knowledge, this is the first work to use frozen VLM signals as an anticipatory cost term inside the CMDP Lagrangian update.

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05.

arXiv (CS.CV) 2026-06-25 DOI: arXiv:2606.25084

Are We There Yet? Exploring the Capabilities of MLLMs in Assistive AI Applications

作者:

Shayon Dasgupta↗Avijit Dasgupta↗C. V. Jawahar↗

Multimodal Large Language Models (MLLMs) have redefined visual understanding by combining vision encoders with large-scale language models. This unified architecture enables strong performance on tasks like image captioning, visual question answering, and multimodal dialogue, often in zero- and few-shot settings. Their general-purpose capabilities and flexible interfaces make MLLMs a promising foundation for real-world vision-language applications. Assistive AI aims to help users interact with their environments through natural language. These scenarios demand robust visual recognition, contextual reasoning, and multilingual comprehension-capabilities that MLLMs are believed to offer. However, their effectiveness in assistive settings remains to be fully understood. In this work, we explore whether MLLMs can support Assistive AI by evaluating state-of-the-art models on real-world tasks: recognizing everyday objects like currency, answering questions based on scene text, and reading visually presented content across multiple languages. To this end, we developed a system, NetraLink, using a head-mounted GoPro to capture real-world egocentric data, and collected a benchmark covering these assistive scenarios. Our findings provide a comprehensive diagnostic of current MLLMs, highlighting their strengths and limitations in enabling assistive technologies grounded in visual perception and language interaction.

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06.

arXiv (CS.CL) 2026-06-12 DOI: arXiv:2606.13177

MemRefine: LLM-Guided Compression for Long-Term Agent Memory

作者:

Minjae Kim↗Jinheon Baek↗Soyeong Jeong↗Sung Ju Hwang↗

Large language model (LLM) agents are increasingly expected to operate over long-term interactions, where information from past dialogues must be preserved and recalled to support future tasks. However, as interactions accumulate, the memory store grows without bound and fills with redundant entries that inflate storage cost and degrade retrieval by crowding out the most useful evidence. Furthermore, this is especially limiting on resource-constrained platforms with hard memory budgets, motivating us to formulate storage-budgeted memory management, the task of keeping an already constructed memory store within a fixed budget while preserving information useful for future interactions. To this end, we then propose MemRefine, an LLM-guided framework that, since surface similarity poorly reflects factual value, uses similarity only to propose candidate pairs and defers delete, merge, and preserve decisions to an LLM judge based on factual content, iterating until the budget is met. Across multiple memory frameworks and long-term conversation benchmarks, MemRefine consistently meets target budgets while preserving downstream performance and outperforming rule-based baselines under tight budgets.

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07.

arXiv (quant-ph) 2026-06-24 DOI: arXiv:2606.24205

From Spectral Singularities to Multipartite Entanglement Scaling at Higher-Order Exceptional Points

作者:

Chunlai Yang↗Shuheng Liu↗Xinyao Huang↗Kaiye Shi↗Qiongyi He↗

arXiv:2606.24205v1 Announce Type: new Abstract: Exceptional points (EPs) are non-Hermitian spectral singularities exhibiting fractional-power responses, yet their implications for multipartite entanglement of interacting quantum many-body systems remain largely unexplored. Here we develop a general framework that links higher-order non-Hermitian degeneracies to the scaling behavior of genuine multipartite entanglement in interacting identical-qubit systems. Permutation symmetry of the identical qubits decomposes the exponentially large Hilbert space into independent irreducible-representation sectors, thereby constraining the maximal EP order of $N$ qubits to $N+1$ rather than $2^N$. Near an $n$th-order EP, genuine multipartite entanglement inherits the spectral response and generically exhibits a fractional-power scaling under weak perturbations. Explicit examples show that conventional two-body interactions support third- and fourth-order EPs with the corresponding entanglement responses, whereas higher-order EPs with genuine multipartite-entangled coalesced states require additional independent interaction channels, such as three-body interactions. Our results establish a fundamental connection among non-Hermitian degeneracies, multipartite entanglement, and symmetry, extending higher-order EP physics from spectral singularities to genuine many-body quantum correlations.

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08.

arXiv (CS.CL) 2026-06-15 DOI: arXiv:2606.14626

Characterizing Cultural Localization in AI-Generated Stories

作者:

Shaily Bhatt↗Supriti Vijay↗Jeremiah Milbauer↗Fernando Diaz↗

The global use of artificial intelligence has increased interest in assessing the ability to generate culturally localized content, including stories. Cultural localization in stories often occurs through either templated localization – the use of cultural markers (e.g., names, locations) in a generic narrative – or holistic localization – the variation of plots, values, and themes, in addition to cultural markers. We propose a method to measure the degree to which content was generated through templated localization. Specifically, we identify the lexical tokens that distinguish stories across nationalities and measure the similarity of the narratives that remain after removing them. In stories generated by five models on 125 topics for 193 nationalities, our method is able to detect that only a small subset (9-17%) of the vocabulary accounts for the variation across nationalities and that the narratives that remain after removing them contain repeated multi-word sequences, suggesting the presence of a shared culturally-agnostic narrative template. Finally, we characterize the cultural markers for their stereotypicality and offensiveness, finding that markers from 19 countries, mostly located in the Global South, are on average offensive.

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09.

arXiv (CS.CL) 2026-06-17 DOI: arXiv:2606.17688

LLMs Infer Cultural Context but Fail to Apply It When Responding

作者:

Yisong Miao↗Jian Zhu↗Vered Shwartz↗

Recent work has shown that LLMs overrepresent dominant cultures, particularly Western ones, while marginalizing others. We investigate whether this affects models' ability to generate culturally adapted responses by evaluating their use of local measurement units based on the user's perceived cultural background. We introduce Cultural and Pragmatic Response Inference (CAPRI), a dataset of conversations with varying levels of cultural cues. Experiments with state-of-the-art LLMs show that models can infer cultural background and recall relevant conventions, but often fail to utilize the information to adapt their answers to the relevant cultural conventions, unless explicitly prompted to perform the tasks sequentially. We further evaluate adaptation to the interpretation of time and quantity expressions, two subjective language grounding dimensions that are affected by culture. We find that models increasingly adapt their answers as cultural cues accumulate, but their priors are not culture-neutral, sometimes aligning with the model's country of origin. Overall, CAPRI provides a resource for future research aimed at narrowing the gap between cultural knowledge and culturally adaptive language generation.

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10.

arXiv (CS.AI) 2026-06-25 DOI: arXiv:2606.25964

WinDOM: Self-Family Distillation for Small-Model GUI Grounding

作者:

Chengheng Li-Chen↗Zhiqian Zhou↗Hao Chen↗Nicolas Chauvin↗

arXiv:2606.25964v1 Announce Type: new Abstract: Small ($\sim$2B) GUI-grounding agents are attractive for on-device deployment, accessibility tooling, and low-cost iteration, but at this scale they face two open recipe questions: how to obtain bounding-box training data without expensive human annotation, and how to combine supervised fine-tuning with reinforcement learning. We address both, with the explicit goal of pushing small-model performance rather than scaling up. WinDOM is a $54{,}425$-record grounding corpus harvested by driving an open-source Windows 11 web reimplementation under headless Playwright, with bounding boxes read directly off the DOM and no OCR or human annotation. Self-Family Distillation (SFD) is a single rejection-sampling cold-start parameterised only by the teacher choice: either an EMA of the student (no external model) or a frozen larger same-family teacher. We then treat the saturation depth of the SFD cold-start as an explicit GRPO hyperparameter. On a Qwen3.5-2B student, the under-saturated cold-start is a better GRPO initialiser than the converged one: SFD-4B with Early-init RL gains $+5.4$ OOD-mean ($+3.5$ ScreenSpot-Pro, $+7.0$ OSWorld-G, $+5.8$ ScreenSpot-V2) over the base. The same-size EMA mode lands within roughly one OOD-mean point of the cross-size $4$B variant ($65.2$ vs $66.3$) without an external teacher.

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11.

arXiv (quant-ph) 2026-06-11 DOI: arXiv:2606.11516

Single Photon Cross-Phase Shifts Can Be Enhanced by Localization in both Frequency and Time

作者:

Xinyu Jiao↗Vida-Michelle Nixon↗Kyle Thompson↗Aephraim Steinberg↗

arXiv:2606.11516v1 Announce Type: new Abstract: Single-photon optical nonlinearities face a fundamental trade-off: maximum nonlinearity requires both spectral resonance (narrow bandwidth) and high peak intensity (short duration), constraints that are incompatible due to the time-energy uncertainty relation. We demonstrate experimentally that this limitation does not need to exist in cases involving post-selection. We measure a cross-phase shift (XPS) produced by a resonant photon from a narrow-band source that is first transmitted through a cold atomic cloud and then localized in time through detection. The peak size of this XPS is greatly enhanced compared to that of Gaussian single-photon-level pulses without post-selection, benefiting from the narrow bandwidth of the resonant prepared state and the high intensity of the post-selected state simultaneously. We measure enhancements in the peak XPS of 6$\pm$1 at an optical depth (OD) of 2.4$\pm$0.1, and our results are in qualitative agreement across a range of optical depths with the recently developed weak value theory of atomic excitation [Thompson et al., APL Quantum 2, 036108 (2025)] for such post-selected photons. This work uncovers new consequences of having simultaneous knowledge of frequency and time, raising new foundational questions about how a particle behaves, and interacts with other systems, when its preparation and post-selection are non-commuting.

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12.

arXiv (CS.AI) 2026-06-16 DOI: arXiv:2601.19612

Safe Exploration via Policy Priors

作者:

Manuel Wendl↗Yarden As↗Manish Prajapat↗Anton Pollak↗Stelian Coros↗Andreas Krause↗

arXiv:2601.19612v3 Announce Type: replace-cross Abstract: Safe exploration is a key requirement for reinforcement learning (RL) agents to learn and adapt online, beyond controlled (e.g. simulated) environments. In this work, we tackle this challenge by utilizing suboptimal yet conservative policies (e.g., obtained from offline data or simulators) as priors. Our approach, SOOPER, uses probabilistic dynamics models to optimistically explore, yet pessimistically fall back to the conservative policy prior if needed. We prove that SOOPER guarantees safety throughout learning, and establish convergence to an optimal policy by bounding its cumulative regret. Extensive experiments on key safe RL benchmarks and real-world hardware demonstrate that SOOPER is scalable, outperforms the state-of-the-art and validate our theoretical guarantees in practice.

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13.

arXiv (quant-ph) 2026-06-16 DOI: arXiv:2606.17036

Grid-state deformation in a no-jump non-Hermitian bosonic dimer

作者:

B. M. Rodriguez-Lara↗H. Ghaemi-Dizicheh↗S. Dehdashti↗A. Hanke↗A. Touhami↗J. N\"otzel↗

arXiv:2606.17036v1 Announce Type: new Abstract: We study the no-jump evolution of ideal grid states in a lossy bosonic dimer with differential decay. The effective non-Hermitian quadratic dynamics induces a complex symplectic flow in phase space that deforms both the primitive lattice vectors and the origin seed. The average decay rate controls common attenuation, while coherent hopping and differential decay control the reduced dimer deformation. The reduced sector contains elliptic, parabolic, and hyperbolic regimes with imaginary spectra, an exceptional point, and real spectra, producing oscillatory, linear, and exponential lattice deformations. Although projected lattice areas can change, the deformation comes from a determinant-one complex symplectic flow on the full four-dimensional phase space. For a Gaussian regularization of the origin seed, we derive the associated complex width matrix and identify the positivity conditions that preserve Gaussian form. For an initial two-mode qunaught product state, the lossless limit recovers the standard beam-splitter generation of a square GKP$+$ Bell pair, while the no-jump dynamics produces its non-Hermitian deformation with a postselection cost set by the no-jump probability.

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14.

arXiv (CS.CV) 2026-06-11 DOI: arXiv:2606.11925

Corpus Augmentation for Sign Language Translation via LLM-Guided Video Stitching

作者:

Zsolt Robotka↗\'Ad\'am R\'ak↗Jalal Al-Afandi↗Andr\'as Horv\'ath↗Gy\"orgy Cserey↗

Sign language translation (SLT) converts sign language video into spoken language text and holds significant promise for improving accessibility and enabling communication between signing and non-signing communities. While large weakly-aligned datasets have enabled pre-training at scale and gloss-free methods have reduced reliance on expert annotation, high-quality parallel sign video-text pairs for fine-tuning remain scarce, limiting generalisation on long-tail vocabulary and unseen constructions. We propose a corpus augmentation approach that requires no additional human annotation, external sign-language video corpora, or generative video models, relying only on the existing gloss-annotated training corpus and an LLM for sentence generation: per-gloss clips are extracted from training videos via CTC forced-alignment, novel gloss-sentence pairs are generated by a corpus-anchored LLM, and synthetic sequences are assembled through random sentence sampling and clip assignment. The resulting synthetic RGB video-text pairs are architecture-agnostic at the downstream training stage and can be consumed directly by RGB-based SLT models, or converted into pose or feature representations by pipelines that derive such inputs from video. Sincan et al. re-evaluated five recent gloss-free methods under strictly identical conditions; the largest verified gain over the GFSLT-VLP baseline was only 0.98 BLEU-4. Our augmentation, applied within the same framework, achieves +2.92 BLEU-4 without any change to architecture or training protocol. We further identify that synthetic data harms vision-language pretraining despite improving its objectives, and that optimising clip transitions for visual smoothness is counter-productive under L2-based criteria; we propose that abrupt boundaries may act as a form of implicit regularisation. Code is available at https://github.com/robizso/slt-datagen.

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15.

arXiv (CS.LG) 2026-06-18 DOI: arXiv:2606.19138

INDEQS: Informed Neural controlled Differential EQuationS

作者:

Michael Detzel↗Gabriel Nobis↗Kristiyan Blagov↗Juri Schubert↗Jackie Ma↗Wojciech Samek↗

arXiv:2606.19138v1 Announce Type: new Abstract: Neural Controlled Differential Equations (NCDE) provide a powerful continuous-time framework for forecasting time series, but standard graph-based extensions typically learn spatial structure purely from data, even in settings where a directed graph structure is known a priori. We introduce Informed Neural controlled Differential EQuationS (INDEQS), a graph-based NCDE forecasting method that incorporates prior knowledge of a directed graph at distinct architectural positions. INDEQS separates inner mixing of hidden states across graph nodes from outer mixing between vector field and control, and offers both a lightweight graph-constrained variant and a more expressive variant, learning additional graph connections from data via adaptive graph convolutions. To systematically study when graph informedness is beneficial in forecasting, we devise a continuous advection simulation on directed graphs, yielding synthetic spatio-temporal datasets with known ground-truth flow structure. We then evaluate INDEQS on two real-world tasks: river discharge forecasting on a hydrological network and traffic flow prediction on PeMS08. Across these synthetic and real-world benchmarks, outer informedness consistently improves mean absolute error over an uninformed NCDE with comparable parameter count, particularly on larger graphs, while inner informedness offers a more parameter-efficient alternative when strict adherence to a known adjacency is desired. A comparison of discrete convolutional and continuous-time decoders further shows that continuous decoders yield better accuracy and greater temporal flexibility on real-world tasks. An implementation of INDEQS and the advection simulation is available at https://github.com/Mitchi1/indeqs.

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16.

arXiv (CS.AI) 2026-06-17 DOI: arXiv:2510.01359

Breaking the Code: Security Assessment of AI Code Agents Through Systematic Jailbreaking Attacks

作者:

Shoumik Saha↗Jifan Chen↗Sam Mayers↗Sanjay Krishna Gouda↗Zijian Wang↗Varun Kumar↗

arXiv:2510.01359v2 Announce Type: replace-cross Abstract: Code-capable large language model (LLM) agents are embedded in software engineering workflows where they can read, write, and execute code, raising "jailbreak" stakes beyond text-only settings. Prior evaluations emphasize refusal or harmful-text detection, leaving open whether agents compile and run malicious programs. We present JAWS-Bench (Jailbreaks Across WorkSpaces), a benchmark spanning three escalating workspace regimes mirroring attacker capability: empty (JAWS-0), single-file (JAWS-1), and multi-file (JAWS-M). We pair this with a hierarchical, executable-aware Judge Framework that tests (i) compliance, (ii) attack success, (iii) syntactic correctness, and (iv) runtime executability, to measure deployable harm. Across seven LLM backends from five families, prompt-only attacks in JAWS-0 achieve 61% compliance; 58% are harmful, 52% parse, and 27% run end-to-end. In JAWS-1, compliance reaches ~100% for stronger models with a mean ASR (Attack Success Rate) ~71%; JAWS-M raises mean ASR to ~75%, with 32% runnable attack code. Wrapping an LLM in an agent increases ASR by 1.6$\times$, by overturning initial refusals during planning and tool use. Similar trends hold for OpenHands, SWE-Agent, and OpenAI Codex, suggesting our JAWS-Bench is agent-agnostic. Category analyses identify which attack classes are most vulnerable and deployable, motivating execution-aware defenses and refusal-preserving agent designs.

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17.

arXiv (CS.CL) 2026-06-18 DOI: arXiv:2606.18850

ScholarSum: Student-Teacher Abstractive Summarization via Knowledge Graph Reasoning and Reflective Refinement

作者:

Bohou Zhang↗Xiaoyu Tao↗Mingyue Cheng↗Huijie Liu↗Qi Liu↗

Abstractive summarization plays a crucial role in enabling efficient understanding of scientific literature, yet it inherently demands both linguistic fluency and factual faithfulness. Existing approaches often fail to reconcile these two requirements. Extractive methods rely on rigid sentence splicing that disrupts macro-level logical coherence, while large language model (LLM)-based generative approaches, despite mastering linguistic fluency, exhibit limited factual consistency. In this work, we propose ScholarSum, a hierarchical reflective graph-based framework that emulates a student-teacher writing process for fluent and faithful scientific summarization. ScholarSum first organizes the document into a hierarchical knowledge graph by segmenting it into semantically coherent units, whose multi-layered community structure captures global logic and macro-level themes. Guided by this global structure, the student generates an initial draft, which is subsequently refined through fine-grained evidence retrieval. To ensure factual consistency, a teacher-like reviewer then iteratively examines the draft, identifies unsupported content, and prompts targeted re-retrieval and rewriting until the summary meets rigorous quality standards. Extensive experiments demonstrate that ScholarSum significantly outperforms previous baselines in terms of both completeness and faithfulness. Our code is available at https://github.com/Xiaoyu-Tao/ScholarSum.

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18.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2606.16421

Beer-Lambert Guided Representation Learning for Unsupervised Anomaly Detection in Sub-THz Food Inspection Images

作者:

Gyutae Hwang↗Sang Jun Lee↗

Food manufacturing requires reliable inspection systems to detect foreign material contamination and maintain product safety. Sub-THz transmission imaging provides material-dependent attenuation characteristics that are useful for detecting low-density contaminants in food products. However, existing unsupervised anomaly detection methods mainly rely on RGB-pretrained visual representations, which may not adequately capture the transmission behavior of Sub-THz images. This paper proposes a Beer-Lambert guided representation learning framework for unsupervised anomaly detection in Sub-THz food inspection images. The proposed method introduces an attenuation decomposition module as an auxiliary regularization module that constrains student representations through attenuation reconstruction during training. In addition to the conventional one-class setting, we introduce a Leave-One-Food-Out protocol to evaluate generalization capability under unseen food categories. Experimental results on the Inline-Food-Inspection-THz dataset show that the proposed method improves overall anomaly detection performance over the baseline method.

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19.

arXiv (CS.CV) 2026-06-25 DOI: arXiv:2606.25657

Steering Vision-Language Models with Joint Sparse Autoencoders

作者:

Huizhen Shu↗Xuying Li↗Hongxu Lin↗Wenjie Sun↗Hui Li↗

Sparse Autoencoders (SAEs) have shown promise for analyzing language models, but applying them to vision-language models (VLMs) often yields representations that are difficult to use as controllable cross-modal steering directions. We introduce the Joint Sparse Autoencoder (JSAE), which uses an explicit alignment constraint to jointly factorize sequence-pooled vision and language activations into shared, interpretable image/caption-level features. Applied to LLaVA, JSAE recovers cross-modal features for recognizable concepts (e.g., food and animals). Through bidirectional interventions (additive steering and suppression), we observe a layer-dependent asymmetry under our protocol: additive steering peaks at mid-to-late (pre-output) layers and weakens at both ends, whereas suppression scores remain within a comparable range across all probed layers within statistical noise. Experiments on three VLMs, namely LLaVA-v1.6-Mistral-7B, Llama3-LLaVA-8B, and the MoE-based Qwen3-VL-30B, show related layer-localized effects across architectures. Together, these results suggest that explicitly aligned sparse representations support more controllable intervention-based analysis of multimodal features, within an identifiable layer range, than the unconstrained alternatives tested here.

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20.

PLOS Computational Biology 2026-06-22 DOI: HASH:15fea16de53dee1cce31700388039efd

TCRBinder: Unified pre-trained language model with paired-chain synergy for predicting T-cell receptor binding specificity

作者:

Weihe Dong↗

by Weihe Dong, Qiang Yang, Long Xu, Xiaokun Li, Kuanquan Wang, Suyu Dong, Gongning Luo, Xianyu Zhang, Tiansong Yang, Xin Gao, Guohua Wang Deciphering how human T cells recognise peptide-HLA (pHLA) complexes underpins next-generation vaccines and personalised immunotherapies, yet extreme sequence diversity and paired-chains interdependence still hamper reliable in silico prediction of T-cell receptor (TCR) specificity. To overcome these hurdles, we built TCRBinder, a paired-chain-aware deep model with a multi-branch encoder that routes each molecular component through dedicated transformer-based modules to capture contextual signals in both HLA pseudo-sequences and antigenic peptides while simultaneously processing the TCR α and β chains. This design captures the synergistic interaction between paired chains to emulate peptide-HLA-TCR (PHT) interactions and expose residue-level contact motifs. Across PHT and peptide-TCR (pTCR) benchmarks, the model delivered state-of-the-art performance (AUC-ROC = 0.911, AUPR = 0.791 for the PHT task) and remained superior on multiple independent datasets. We tracked the dynamics of clonal expansion and, in a large SARS-CoV-2 repertoire containing completely unseen peptides, improved the AUC-ROC by up to 16.3% over the leading alternatives. Moreover, TCRBinder provided mechanistic insights by pinpointing contact hotspots and quantifying residue contributions to binding probability. These capabilities position TCRBinder as a versatile tool for rational antigen discovery, immunotherapy stratification, and neoantigen vaccine design.

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21.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2606.16271

Contrastive Learning for Seismic Horizon Tracking with Domain-Specific Priors

作者:

Alexandre Thouvenot↗Lionel Boillot↗Vincent Gripon↗

Unsupervised 3D seismic horizon tracking faces a key limitation: signal-based propagators provide accurate trace-level alignment but often fail near faults, whereas texture-driven deep models are more robust to discontinuities, typically at the cost of labeled data requirements and reduced trace-level precision. We propose a self-supervised fusion of both paradigms in which signal-derived local horizon correspondences act as domain-specific priors to train a texture-based deep learning model. Specifically, we estimate reliable trace-to-trace flows from reflector slopes and use them to form positive pairs in a contrastive objective, while restricting training to high-confidence neighborhoods, optionally augmented with a fault mask. The objective is not to infer ambiguous correspondences close to discontinuities, but to preserve horizon identity across them. As a result, the network learns voxel-wise embeddings that preserve local signal continuity while enabling horizon propagation beyond discontinuities through similarity search. Experiments on the public F3 dataset and a faulted synthetic dataset achieve lower mean absolute error (MAE) than unsupervised baselines and competitive performance against a semi-supervised method using a single labeled slice.

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22.

arXiv (quant-ph) 2026-06-12 DOI: arXiv:2606.13641

Generalized two-qubit Hamiltonian for Projective Quantum Feature Maps

作者:

Rafael Sim\~oes do Carmo↗Edson Amaro Junior↗Felipe Fanchini↗

arXiv:2606.13641v1 Announce Type: new Abstract: Projected quantum feature maps provide a strategy for using quantum processors as feature generators for classical machine-learning models. Building on counterdiabatic Ising-glass and one-dimensional Heisenberg PQFMs, we introduce a generalized two-qubit Hamiltonian-based PQFM that provides a unified way to encode classical features through local Pauli fields and pairwise two-qubit Pauli interactions. This construction allows distinct classical variables to be embedded along different Pauli axes of the same qubit, increasing the information density of shallow circuits while remaining compatible with hardware constraints. We develop and implement these methods in pqfmlib, a publicly available Python library for constructing, executing, and benchmarking Hamiltonian-based PQFMs.We then benchmark the generalized Hamiltonian PQFMs against reference PQFMs on four biomedical classification datasets under a nested cross-validation protocol with paired statistical tests. Quantum features are generated using both IBM quantum processors with up to 156 qubits and statevector simulations. Our results show that the generalized two-qubit Hamiltonian family provides the most consistent pattern of statistically supported gains over matched classical baselines, although the performance of all methods depends on the dataset, encoding strategy, measured observables, and hardware conditions. These findings support generalized Hamiltonian PQFMs as a promising route toward near-term quantum utility.

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23.

arXiv (quant-ph) 2026-06-25 DOI: arXiv:2606.25933

From spectral structure to sensing limits in quantum thermometry

作者:

Youssef Aiache↗Simone Cavazzoni↗Abderrahim El Allati↗Paolo Bordone↗Matteo G. A. Paris↗

arXiv:2606.25933v1 Announce Type: new Abstract: The precision of a quantum thermometer is fundamentally constrained by the spectral structure of the probe itself, and a systematic mapping between the configurations of energy levels and thermometric performance provides relevant information to design optimized devices. In this work, we establish such a mapping by analyzing a broad class of quantum systems, ranging from finite spin ensembles and degenerate atoms to confining potentials, quantum walks, and continuous-spectrum models. We derive exact scaling laws for the quantum Fisher information, revealing two distinct high-temperature universality classes: finite-spectrum probes exhibit a $T^{-4}$ decay, while unbounded or continuous spectra yield a slower $T^{-2}$ decay. At low temperatures, we show that sensitivity, though universally exponentially suppressed, can be enhanced arbitrarily by engineering degenerate excited states or a quantum walk on a fully connected topology. By contrast, specific quantum walk topologies provide a distinct enhancement mechanism based on gap engineering, whereby an optimal network size yields an optimized $T^{-2}$ low-temperature scaling. Furthermore, power-law spectra enable tunable scaling of thermometric performance with system size, offering a design principle for optimal probes in specific temperature windows. Our results contribute to transform spectral information into a resource for quantum thermometry, providing both fundamental bounds and practical guidelines to tailored temperature sensing.

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24.

arXiv (CS.AI) 2026-06-19 DOI: arXiv:2603.09420

Class-Incremental Motion Forecasting

作者:

Nicolas Schischka↗Nikhil Gosala↗B Ravi Kiran↗Senthil Yogamani↗Abhinav Valada↗

arXiv:2603.09420v3 Announce Type: replace-cross Abstract: Motion forecasting enables autonomous vehicles to anticipate scene evolution by predicting the future trajectories of dynamic agents. However, existing approaches typically assume a closed-world setting with a fixed object taxonomy and access to high-quality perception, limiting their applicability in the real world where perception is imperfect, and new object classes may emerge over time. In this work, we introduce class-incremental motion forecasting, a novel setting in which new object classes are sequentially introduced over time and future object trajectories are predicted directly from camera images. We propose the first end-to-end framework for this setting, which adapts to newly introduced classes while mitigating catastrophic forgetting of previously learned ones. Our method generates motion forecasting pseudo-labels for known classes and matches them with 2D instance masks from an open-vocabulary segmentation model. This 3D-to-2D keypoint voting mechanism filters inconsistent and overconfident predictions, while a query feature variance-based replay strategy samples informative past sequences to preserve prior knowledge. Extensive evaluations on nuScenes and Argoverse 2 show that our approach successfully preserves performance on known classes while effectively adapting to novel ones. We further demonstrate zero-shot transfer to real-world driving and show that the framework extends naturally to open- and closed-loop end-to-end class-incremental planning on nuScenes and NeuroNCAP. Code and models will be made publicly available at https://omen.cs.uni-freiburg.de.

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25.

arXiv (CS.LG) 2026-06-25 DOI: arXiv:2603.07221

Margin in Abstract Spaces

作者:

Yair Ashlagi↗Roi Livni↗Shay Moran↗Tom Waknine↗

arXiv:2603.07221v2 Announce Type: replace Abstract: Margin-based learning, exemplified by linear and kernel methods, is one of the few classical settings where generalization guarantees are independent of the number of parameters. This makes it a central case study in modern highly over-parameterized learning. We ask what minimal mathematical structure underlies this phenomenon. We begin with a simple margin-based problem in arbitrary metric spaces: concepts are defined by a center point and classify points according to whether their distance lies below $r$ or above $R$. We show that whenever $R>3r$, this class is learnable in any metric space. Thus, sufficiently large margins make learnability rely only on the triangle inequality, without any linear or analytic structure being necessary. Our first main result extends this phenomenon to concepts defined by bounded linear combinations of distance functions, and reveals a sharp threshold: there exists a universal constant such that whenever the margin is larger than this constant, the class is learnable in every metric space, while below it there exist metric spaces where it is not learnable at all. We then ask whether margin-based learnability can always be explained via an embedding into a linear space – that is, reduced to linear classification in some Banach space through a kernel-type construction. We answer this negatively by demonstrating a margin learnable class that cannot be embedded into any Banach space in which linear classification with margins is learnable.

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