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01.
medRxiv (Medicine) 2026-06-15

Routine use of oral iron for people with heart failure and iron deficiency in primary care; retrospective cohort study

作者:
Maharajan↗Jones↗Bankhead↗Erone↗Haynes↗Katumba↗Li↗Maynard↗Roy↗Shah↗Stanworth↗Smith↗…

Aims: Iron deficiency is common among people with heart failure and associated with morbidity and mortality. While intravenous iron improves clinical outcomes, oral iron continues to be prescribed in routine practice despite limited evidence of benefit. Methods: We completed a retrospective primary care cohort study (2016 to 2021) to investigate the proportion of people with an incident diagnosis of heart failure who had iron deficiency identified (defined as ferritin

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02.
arXiv (quant-ph) 2026-06-16

REGRID-QAOA: A Resource-Efficient Graph-Reduced Hybrid QAOA Framework for Physics-Constrained Power System Islanding

作者:
Yuqi Jiang↗Yuqi Zhang↗Zhiding Liang↗Qiang Guan↗Yan Li↗Ganesh Kumar Venayagamoorthy↗

arXiv:2606.15083v1 Announce Type: new Abstract: Quantum computing has rapidly emerged as a powerful paradigm for tackling computationally demanding problems. In particular, quantum optimization shows strong promise for hard combinatorial problems in power systems, where increasing distributed energy penetration heightens the need for intentional islanding to maintain grid reliability and resilience. However, power system islanding is an NP-hard combinatorial optimization problem that becomes computationally prohibitive for classical solvers as network size grows, motivating the use of quantum computing as a promising alternative pipeline. This study develops a resource-efficient hybrid QAOA islanding framework that brings physics-constrained power-system partitioning into the quantum optimization workflow. The framework combines coherency-informed graph reduction, physics-aware constraint modeling, and structured post-processing to efficiently convert shallow-circuit QAOA samples into high-quality feasible islanding decisions without deep circuits or large shot budgets. The proposed framework is validated on the standard IEEE benchmark systems (9-, 14-, 24-, 30-, 39-, and 57-bus), demonstrating that the hybrid workflow achieves Gurobi-optimal solution quality with a clear quantum resource advantage over vanilla QAOA, while the resulting islanding solutions satisfy all physical feasibility requirements after network separation. This study establishes QAOA-based islanding as a viable quantum approach for critical infrastructure, with structured post-processing as the key enabler of quantum resource efficiency.

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03.
arXiv (CS.LG) 2026-06-16

Assessing Predictive Models for Fairness Based on Movement Patterns

作者:
Francesco Lettich↗Mario A. Nascimento↗Chiara Pugliese↗Chiara Renso↗

arXiv:2605.23234v3 Announce Type: replace Abstract: Assessing the spatial fairness of predictive models involves establishing whether they are statistically penalizing (favoring) individuals associated with certain geographical locations. Literature on this topic makes the fundamental assumption that each individual is assigned to a single geographical location (e.g., place of residence). However, fairness with respect to the set of locations where one has been, i.e., their movement patterns over different regions, also matters when fairness is considered. Consequently, we argue that it is necessary to generalize the notion of spatial fairness to also include movement patterns, leading to the novel problem of assessing predictive models for fairness relative to the movements of individuals. To deal with this problem, we propose an approach that first associates the movements of individuals to certain geographic regions, considering multiple spatial partitions with different resolutions and alignments, and then employs a suitable spatial scan statistic to assess whether a predictive model is fair based on movement patterns. In the experimental evaluation, we study the performance of our approach over thousands of synthetic unfair datasets, showing that it is effective at detecting this new type of unfairness and at retrieving the set of objects treated unfairly, while localization performance exhibits a consistent multi-resolution trade-off.

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04.
arXiv (quant-ph) 2026-06-17

Fermionic Hamiltonian engineering with local control

作者:
\"Ozg\"un Kum↗Matthias Zipper↗Ludwig Mathey↗Martin Kliesch↗

arXiv:2606.17158v1 Announce Type: new Abstract: Quantum simulators enable the exploration of complex quantum phenomena in condensed-matter systems by reproducing their dynamics on controllable quantum devices. However, experimental constraints often restrict the class of Hamiltonians that can be realized natively. Hamiltonian engineering addresses this limitation by expanding the set of accessible target Hamiltonians from a fixed system Hamiltonian defined by the hardware. We introduce a new framework for fermionic Hamiltonian engineering based on conjugating free evolution under the system Hamiltonian with sequences of experimentally feasible local fermionic unitaries. The required sequences and free-evolution times are obtained efficiently via a linear program. By interleaving system evolution with these local unitaries, our method realizes effective time evolution under a broad class of target Hamiltonians, with intrinsic robustness to finite-pulse-time errors. In particular, we demonstrate that arbitrary complex tunnelling coefficients can be realized, constrained only by the connectivity of the underlying system Hamiltonian. We illustrate this capability by engineering the dynamics of the non-interacting Harper-Hofstadter model on a 1088-mode lattice and an interacting Fermi-Hubbard chain with complex tunnelling coefficients. By construction, our approach avoids the continuous energy absorption inherent to Floquet engineering.

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05.
arXiv (CS.AI) 2026-06-25

AI-Assisted Computational Reproducibility on the FABRIC Testbed

作者:
Komal Thareja↗Paul Ruth↗Berent Aldikacti↗Michael Zink↗

arXiv:2606.25879v1 Announce Type: cross Abstract: Computational reproducibility remains difficult despite being central to scientific research. In this paper, we show how the international FABRIC testbed, combined with large language model (LLM) coding assistants through LoomAI, can simplify reproducing published experiments across multiple domains. We reproduced three case studies on FABRIC, covering BBR-family congestion-control evaluations, LAMMPS molecular dynamics scaling benchmarks on a CPU-only MPI cluster, and stress protein homeostasis genomics pipelines. Rather than focusing only on matching numerical outputs, we evaluate whether the reproduced experiments support the same scientific conclusions as the original studies. The AI assistant was effective in setting up the environment, adapting code, and debugging, but struggled with the analysis stages that lacked clearly defined workflows, which required human guidance to establish execution order and data dependencies. Across the case studies, the AI-assisted workflow reduced reproduction effort by roughly 4–6 times. We conclude with practical recommendations for improving AI-assisted reproducibility on research testbeds.

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06.
arXiv (quant-ph) 2026-06-16

Watching a Superconducting Coplanar Waveguide Heat Up with a Single Color Center

作者:
Ioannis Karapatzakis↗Jeremias Resch↗David Hunger↗Wolfgang Wernsdorfer↗

arXiv:2606.15398v1 Announce Type: new Abstract: Single color centers in diamond offer a local probe of their cryogenic environment, providing a direct way to quantify heating in spin-control hardware. Here, we establish a single spectrally stable tin-vacancy (SnV) center as an on-chip thermometer for a diamond membrane and use it to characterize microwave- and radio-frequency-induced heating in a superconducting coplanar waveguide patterned on the same chip. We first calibrate the temperature dependence of the optical C-transition frequency and linewidth from $20\,\mathrm{K}$ down to the few-kelvin regime. At lower temperatures, where the optical response becomes weakly temperature dependent, we use the spin-lattice relaxation time $T_1$ as a complementary thermometer and tune its sensitivity with the transverse magnetic-field component. Applying this local thermometer to a niobium coplanar waveguide, we observe magnetic-field-dependent superconducting breakdown under GHz drive, accompanied by abrupt heating of the diamond. In contrast, at $20\,\mathrm{MHz}$ and $400\,\mathrm{mT}$, relevant for nuclear-spin control, we detect no measurable heating up to the breakdown threshold of $9.4\,\mathrm{dBm}$, corresponding to $B_\mathrm{ac}\sim1.2\,\mathrm{mT}$. These results define a safe operating window for superconducting microwave and RF control structures in diamond-based quantum nodes.

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07.
arXiv (quant-ph) 2026-06-11

Multipartite reference-frame-independent quantum cryptographic communication

作者:
Donghwa Lee↗Kyujin Shin↗Hyang-Tag Lim↗Yosep Kim↗Yong-Su Kim↗

arXiv:2606.12284v1 Announce Type: new Abstract: Reference frame mismatch among communication parties introduces errors in quantum cryptographic protocols. As the number of participants increases, aligning reference frames becomes increasingly difficult, complicating multipartite quantum cryptographic implementations. Here, we theoretically and experimentally investigate multipartite reference-frame-independent (RFI) quantum cryptographic communication using Greenberger-Horne-Zeilinger (GHZ) states. We generalize the bipartite RFI security parameter $C$ to an $N$-party parameter $C_N$ and derive the asymptotic secret key rate expressed solely in terms of experimentally accessible quantities. We analyze the key rate under global and local depolarizing noise models and find that increasing the number of parties $N$ enhances robustness against global depolarizing noise while increasing vulnerability to local channel noise. We also present a proof-of-principle experimental demonstration of four-party RFI quantum cryptographic communication using four-photon GHZ states, confirming the reference-frame invariance of both the $C_4$ parameter and the secret key rate under various reference frame rotations.

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08.
medRxiv (Medicine) 2026-06-16

Exercise Training Improves Skeletal Muscle Insulin Sensitivity and Reprograms the Adipose Transcriptome in Heavier Monozygotic Twins

作者:
Hentila↗Ullrich↗Ojala↗Lietzen↗M. S↗Heiskanen↗M. A↗Van der Stede↗Honkala↗Helmio↗Rajander↗Eskola↗…

Exercise training improves skeletal muscle insulin sensitivity, yet its effects on white adipose tissue remain incompletely understood. We investigated how adiposity and exercise training influence insulin-stimulated glucose uptake in skeletal muscle and abdominal subcutaneous adipose tissue (ASAT), alongside adaptations in gene expression and DNA-methylation. Ten monozygotic twin pairs discordant for BMI underwent [18F]FDG-PET/CT imaging of skeletal muscle (vastus lateralis, VL) and ASAT during a euglycemic-hyperinsulinaemic clamp before and after six months of exercise training. VL and ASAT biopsies were analyzed using mRNA-sequencing and reduced representation bisulfite sequencing. Exercise training improved whole-body and VL insulin sensitivity in leaner and heavier co-twins (p

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09.
arXiv (CS.CL) 2026-06-18

Trade-offs in Medical LLM Adaptation: An Empirical Study in French QA

作者:
Ikram Belmadani↗Oumaima El Khettari↗Carlos Ramisch↗Frederic Bechet↗Richard Dufour↗Benoit Favre↗

The development of large language models (LLMs) has led to an increased focus on their adaptation to specialized domains and languages, yet the effectiveness of domain adaptation strategies remains unclear. We present a study of medical domain adaptation using French medical question-answering (QA) as a case study. We compare continual pretraining (CPT), supervised fine-tuning (SFT), and their combination across three model families, multiple sizes, and three initialization types, explicitly disentangling adaptation effects from base model choice. We evaluate both multiple-choice (MCQA) and open-ended QA (OEQA) under greedy and constrained decoding using automatic metrics and LLM-as-a-Judge evaluation. For MCQA, CPT+SFT most often achieves the best scores, but gains over SFT are small and frequently not statistically significant, making SFT a strong and cost-effective default. For OEQA, CPT consistently improves overlap-based metrics, while SFT often degrades generation quality; instruction tuning and CPT+SFT are preferred by LLM-based evaluation. Cross-lingual experiments further show effective transfer from French adaptation to English benchmarks. Overall, we provide practical guidelines for selecting adaptation strategies under computational constraints.

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10.
arXiv (CS.CV) 2026-06-16

CRIS: Cross-Plane Self-Supervised Isotropic Restoration for Anisotropic Volumetric Imaging Across Modalities

作者:
Adi Ahituv↗Anat Ilivitzki↗Moti Freiman↗

Anisotropic volumetric acquisitions are common in clinical MRI and volume electron microscopy (vEM), where sparse through-plane sampling creates thick slices or sections that degrade orthogonal reformats and downstream analysis. We present CRIS, a cross-plane self-supervised framework for isotropic restoration without paired isotropic ground truth. CRIS casts 3D restoration as 2D stripe completion on orthogonal reformats of an isotropic grid: high-resolution in-plane slices are synthetically degraded and periodically masked for training, while at inference blank slices define the isotropic grid, two orthogonal reformats are restored, and predictions are fused by multi-view averaging. We evaluate CRIS on two MRI cohorts and two microscopy benchmarks up to 8x anisotropy. On brain MRI, CRIS achieves 32.921 +/- 0.436 dB PSNR and 0.9631 +/- 0.0027 SSIM, outperforming interpolation, SMORE4, SIMPLE, SA-INR, and ATME, and gives the best segmentation consistency (Dice 0.940 +/- 0.004, ASSD 0.245 +/- 0.014 mm, HD99 1.275 +/- 0.061 mm). On reference-free abdominal MRI, CRIS reduces FID/KID to 48.714/0.023. On vEM, CRIS outperforms interpolation, NIIV, and vEMINR, reaching 29.133 dB/0.834 3D PSNR/SSIM at 4x, 27.123 dB/0.734 on EPFL at 8x, and 21.915 dB/0.699 on noisy hemibrain data. In a robustness experiment, one variable-gap CRIS model evaluated across gap factors 3–7 and coronal, axial, and sagittal degradations maintained higher PSNR/SSIM than interpolation (36.36–31.14 dB and 0.977–0.932 vs. 33.07–27.85 dB and 0.951–0.853). These results support CRIS as a modality-flexible route to isotropic restoration without paired isotropic targets or configuration-specific retraining. Code is available at https://github.com/adi-hatav/CRIS.

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11.
arXiv (CS.CV) 2026-06-24

Fine-Grained Open-Vocabulary Object Detection with Fined-Grained Prompts: Task, Dataset and Benchmark

作者:
Ying Liu↗Yijing Hua↗Haojiang Chai↗Yanbo Wang↗TengQi Ye↗

Open-vocabulary detectors are proposed to locate and recognize objects in novel classes. However, variations in vision-aware language vocabulary data used for open-vocabulary learning can lead to unfair and unreliable evaluations. Recent evaluation methods have attempted to address this issue by incorporating object properties or adding locations and characteristics to the captions. Nevertheless, since these properties and locations depend on the specific details of the images instead of classes, detectors can not make accurate predictions without precise descriptions provided through human annotation. This paper introduces 3F-OVD, a novel task that extends supervised fine-grained object detection to the open-vocabulary setting. Our task is intuitive and challenging, requiring a deep understanding of Fine-grained captions and careful attention to Fine-grained details in images in order to accurately detect Fine-grained objects. Additionally, due to the scarcity of qualified fine-grained object detection datasets, we have created a new dataset, NEU-171K, tailored for both supervised and open-vocabulary settings. We benchmark state-of-the-art object detectors on our dataset for both settings. Furthermore, we propose a simple yet effective post-processing technique. Our data, annotations and codes are available at https://github.com/tengerye/3FOVD.

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12.
arXiv (CS.LG) 2026-06-11

GLACIER: A Multimodal Student-Teacher Foundation Model for Molecular Property Prediction

作者:
Emily Nguyen↗Yongchan Hong↗Harsh Toshniwal↗Yan Liu↗Andreas Luttens↗

arXiv:2606.11382v1 Announce Type: new Abstract: Deep learning models facilitate the discovery of molecules with tailored properties among billions of candidate compounds. However, the computational burden to develop and deploy state-of-the-art models continuously increases, limiting their scalability. Most large-scale models are unimodal in nature and overlook the potential to leverage complementary molecular data modalities. To address these shortcomings, this paper introduces the Graph-Language Alignment for Chemical Inference and Exploration using Representations (GLACIER) model, a student-teacher framework that integrates molecular graphs, SMILES strings, and physicochemical descriptors to learn rich molecular embeddings. Our framework consists of three stages: (1) we pretrain three student encoders on 100,000 drug-like molecules: a message-passing neural network for molecular graphs, a transformer-based encoder for SMILES strings, and a multilayer perceptron for physicochemical descriptors, (2) we fuse these student modalities using a novel Finsler geometry-aware module, and (3) distill complementary knowledge from large teacher models, including MiniMol and MolFormer, into a single lightweight model via contrastive learning. We demonstrate that GLACIER is a robust framework that delivers high predictive performance and computational efficiency in complex molecular property prediction tasks. Our code is publicly available at https://github.com/eemokey/glacier.

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13.
medRxiv (Medicine) 2026-06-18

Looked but didn't see: inattentional blindness and yes-bias confabulation in vision-language models

作者:
Raymond↗J. D↗Hu↗Solomon↗B. D↗Duong↗

Previous work showed that many participants fail to notice a gorilla in a video of people playing basketball. Another study found that 83% of trained radiologists failed to report a gorilla figure inserted into a chest CT nodule-search task, even though eye-tracking revealed that most observers had foveated the figure. We ask whether a similar phenomenon exists in contemporary vision-language models (VLMs). We find that (i) VLMs are capable of spotting the gorilla in both still-frame images and videos of lung CT scans; (ii) models display inattentional blindness, which varies according to model generation and type of stimulus presented; (iii) Gemini-3.1-Pro outperforms most other flagship and open-weight VLMs at identifying the presence or absence of the gorilla. We additionally ran a segmentation experiment utilizing two different model classes: a generalist (SAM 3), which found the gorilla but produced little to no results for anatomy-based prompts; a medical specialist (BiomedParse), which produced more promising anatomy-based results but flagged "gorilla" on gorilla-free control videos on 82% of frames. The behavioral signature of inattentional blindness reproduces in VLMs, but a unique confabulation failure mode means that any "did the model see X" claim requires signal-detection analysis with a matched-control false-alarm baseline.

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14.
PLOS Computational Biology 2026-06-08

Statistics of cortical representational drift can enable robust readout

作者:
Charles Micou↗

by Charles Micou, Timothy O’Leary Representational drift of fixed stimuli, learned tasks and familiar environments is observed in many brain areas, leading to reconfiguration of population codes over days to weeks. This raises the question of whether downstream brain regions employ mechanisms to track changes in population activity and thus preserve the fidelity of the information they extract. We show that the statistical properties of drift have a significant impact on such mechanisms. Over an extended period, a net change in population tuning due to drift can arise from an accumulation of small changes distributed across the population, or via abrupt jumps that affect smaller subsets of cells at each time point. We demonstrate that an adaptive readout can exploit the heavy-tailed statistics of abrupt jumps to maintain a more stable readout using a simple inference mechanism. Using experimental data, we investigate the extent to which heavy-tailed drift statistics are observed during representational drift in the posterior parietal cortex and visual cortex. We find that experimentally measured drift does not conform to a Gaussian random walk. Instead, we find sudden jumps in neural tuning that would be advantageous for a downstream observer adapting to changes in representation. These observations motivate future study to determine whether adaptive decoding mechanisms exist in the brain and to determine the physiological mechanisms that shape the statistics of representational drift.

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15.
arXiv (CS.AI) 2026-06-24

CompressKV: Semantic-Retrieval-Guided KV-Cache Compression for Resource-Efficient Long-Context LLM Inference

作者:
Xiaolin Lin↗Jingcun Wang↗Olga Kondrateva↗Yiyu Shi↗Bing Li↗Grace Li Zhang↗

arXiv:2606.24467v1 Announce Type: new Abstract: Long-context large language model (LLM) inference is increasingly constrained by the memory footprint and decoding cost of key-value (KV) caches, limiting sustainable deployment on resource-constrained hardware. Existing KV cache eviction methods typically apply heuristic token scoring over all heads in GQA-based LLMs. These methods ignore the different functionalities of attention heads, leading to the eviction of critical tokens and thus degrading the performance of LLMs. To address this issue, we propose CompressKV, a resource-efficient KV-cache compression framework for GQA-based LLMs. Instead of aggregating attention scores from all heads, CompressKV identifies Semantic Retrieval Heads (SRHs) that capture both the initial and final tokens of a prompt and semantically important mid-context evidence, and uses them to select tokens whose KV pairs should be retained. Furthermore, CompressKV allocates cache budgets across layers according to offline estimates of layer-wise eviction error. Experiments on LongBench and Needle-in-a-Haystack show that CompressKV consistently outperforms existing KV-cache eviction methods across memory budgets. Notably, it preserves over 97\% of full-cache performance using only 3\% of the KV cache on LongBench question-answering tasks and achieves 90\% accuracy with just 0.7\% KV storage on Needle-in-a-Haystack. These results demonstrate an improved resource–performance trade-off for long-context LLM inference. Our code is publicly available at: https://github.com/TUDa-HWAI/CompressKV

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16.
arXiv (CS.LG) 2026-06-11

Energy Use of AI Inference, Efficiency Pathways, and Test-Time Scaling

作者:
Felipe Oviedo↗Fiodar Kazhamiaka↗Esha Choukse↗Allen Kim↗Amy Luers↗Melanie Nakagawa↗Ricardo Bianchini↗Juan M. Lavista Ferres↗

arXiv:2509.20241v2 Announce Type: replace Abstract: As AI inference scales to billions of queries, estimates of per-query energy use are increasingly important for capacity planning, efficiency interventions, and policy. Yet many public estimates assume non-production settings, leading to systematic overestimation. We introduce a bottom-up framework estimating inference energy from token throughput, node power, and overhead under large-scale deployment assumptions. For frontier-scale models (>200B parameters) on H100 nodes, we estimate a median energy of 0.31 Wh/query (IQR 0.16-0.60), indicating widely cited estimates are overstated by 4-20x. In test-time scaling scenarios 15x longer than typical queries, the median energy rises 13x to 3.91 Wh (IQR 2.15-7.05). Across models, serving systems, and hardware, we estimate 8-20x line-of-sight energy reductions. At datacenter scale, serving 1 billion queries/day requires 0.7 GWh; if 10% are long queries, demand rises to 1.7 GWh/day. With efficiency interventions, it falls to 0.8 GWh/day, mitigating the energy impact of test-time scaling.

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17.
arXiv (quant-ph) 2026-06-24

How rare are Markovian quantum dynamics?

作者:
Charlotte B\"acker↗Nick Maryshchak↗Walter T. Strunz↗

arXiv:2606.24511v1 Announce Type: new Abstract: A profound understanding of decoherence and dissipation in quantum dynamics is crucial for the realistic modeling of the evolution of quantum systems. In open quantum dynamics one distinguishes between a memoryless, so-called Markovian evolution and dynamics incorporating memory effects, termed non-Markovian. In this work we study how prevalent memory effects are in the set of all such dynamics. We thus investigate how often a Markovian description is applicable. This question is approached by investigating randomly generated two-step qubit dynamics with respect to different concepts and witnesses of non-Markovianity. We observe that almost all dynamics are non-Markovian, and only a small (yet finite) fraction is Markovian. Furthermore, we study how this proportion changes when considering certain subclasses such as lower rank or mixed-unitary dynamics. Importantly, our results shed light on the relative ratios of – and interrelations between – the sets of dynamics that are non-Markovian with respect to different criteria. Finally, we investigate the fraction of dynamics in which the memory effects are necessarily of quantum nature and establish a connection between two recently developed concepts that characterize the quantumness of memory in non-Markovian dynamics.

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18.
arXiv (CS.LG) 2026-06-11

Bootstrapped Monitoring: Leveraging Transparent Reasoning to Oversee Stronger AI Agents

作者:
Frank Xiao↗Mary Phuong↗

arXiv:2606.11998v1 Announce Type: new Abstract: Trusted monitoring is a cornerstone of AI control. However, as frontier models grow more capable, the increasing capabilities gap between trusted and untrusted models may render trusted models unreliable monitors. We introduce bootstrapped monitoring, a protocol that addresses this by inserting a stronger, intermediate untrusted model with transparent chain-of-thought reasoning into the oversight chain. The untrusted monitor ($U_m$) evaluates the agent's actions, while a weaker trusted model ($T$) oversees $U_m$'s reasoning to detect collusion. We evaluate bootstrapped monitoring on multi-turn software engineering tasks (BashArena) across multiple agents and monitors. Bootstrapped monitoring substantially improves catch rates over trusted-only monitoring, even when the untrusted monitor actively colludes with the agent, provided we have access to its raw chain-of-thought. Our results suggest that bootstrapped monitoring can extend the useful lifetime of trusted models in control as AI capabilities advance.

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19.
bioRxiv (Bioinfo) 2026-06-10

A Unified Spatial AI Framework for Cross-Domain Tissue-State Analysis in Trauma, Oral, and Cardiovascular Pathology

作者:
Pham↗T. D↗

Objective: To develop a cross-domain spatial AI framework for identifying conserved tissue-state organisation across trauma, oral disease, and cardiovascular tissue using spatial transcriptomic data. Methods: Four public spatial transcriptomic datasets spanning wound healing, periodontitis, oral squamous cell carcinoma, and cardiac tissue were integrated using recurrence modelling, graph-based spatial learning, fuzzy tissue-state analysis, and tensor decomposition. Cross-domain coupling, spatial fragmentation, recurrence structure, and permutation-based topological validation were evaluated. Results: Six conserved fuzzy tissue states were identified, dominated by extracellular matrix remodelling, fibroblast/stromal activation, endothelial signalling, and inflammatory pathways. Latent embedding analysis demonstrated strong overlap between trauma and oral domains, while cardiovascular tissue exhibited more compact spatial organisation. Oral inflammatory tissue showed the highest fragmentation, whereas cardiovascular tissue demonstrated greater recurrence coherence. Tensor decomposition identified conserved stromal-remodelling programmes across domains. Permutation testing confirmed significantly elevated graph modularity and reduced spatial entropy relative to null distributions. Conclusion: The proposed framework identified conserved spatial tissue-state architecture linking wound healing, oral pathology, and cardiovascular tissue despite differences in tissue origin, pathology, and acquisition technology. Significance: These findings demonstrate the potential of spatial AI for investigating conserved stromal and inflammatory microenvironmental organisation across clinically related disease systems and may support spatial biology research in trauma–oral–systemic health.

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20.
arXiv (quant-ph) 2026-06-17

Photon anti-bunching in high harmonic generation

作者:
Philipp Stammer↗Javier Rivera-Dean↗Maciej Lewenstein↗

arXiv:2606.17620v1 Announce Type: new Abstract: Photon anti-bunching is the direct evidence for the existence of photons without having a classical counterpart. Unlike bunching of photons, which can have a semi-classical description, the effect of photon anti-bunching can only be understood with quantized electromagnetic fields. However, for the process of high harmonic generation (HHG), where many photons of the driving field are upconverted to a single photon of higher energy, there is yet no clear evidence for the presence of individual photon emission. The key result of this work is the prediction of photon anti-bunching in the process of HHG, marking it the first theoretical discovery of non-classicality in the temporal correlations of HHG photons. While other non-classical signatures in HHG, such as sub-Poissonian statistics or squeezing, have been discussed for an ensemble of photons, the anti-bunching signature reported here is a signature of a single photon. This is achieved by using the recently developed Heisenberg picture approach for quantum optical HHG, revealing clear anti-bunching signatures in the intensity correlation function across the entire harmonic spectrum.

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21.
arXiv (CS.LG) 2026-06-24

Sesame: Structure-Aware Molecular Generation via Spatial Density-Map Conditioning

作者:
Konstantin Yatsenko↗Arvind Thiagarajan↗

arXiv:2606.23856v1 Announce Type: new Abstract: Generative molecular models for drug design are a promising direction with much active research. In the next phase of computational drug design, such models will need to understand small molecule structure and protein-ligand interactions, and they will need to possess the machinery to generate molecules de novo. Incorporating each feature poses a critical challenge. Equally important, yet often treated as secondary, is the ability to grow a molecule from a partial starting point – a scaffold or fragment supplied by a chemist – which is the central operation of lead optimization. We present Sesame (Spatial Evoformer for a Structure-Aware Molecular Engine), a diffusion-based molecular generation model that leverages a novel spatial pairformer module to condition on partial molecular structure and the surrounding protein pocket, both expressed as continuous spatial density maps. This single conditioning mechanism supports both de novo generation and fragment-conditioned lead optimization, letting a medicinal chemist prune a hit to a scaffold and have Sesame grow it in productive ways. In addition to this module, we also introduce a diffusion framework for joint denoising of atom types, bond types, and positions, along with a trajectory finetuning scheme that trains on the model's own sampling rollouts to improve generation quality. Sesame is trained on a large corpus of ligand-only and protein-ligand datasets.

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22.
Nature (Science) 2026-06-22

Why heritage sites are at risk in a warming world — and how to save them

作者:
William Megarry↗

As rising seas and intensifying disasters threaten historic sites worldwide, new ways to understand, preserve and adapt these places are needed urgently. As rising seas and intensifying disasters threaten historic sites worldwide, new ways to understand, preserve and adapt these places are needed urgently.

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23.
arXiv (CS.LG) 2026-06-12

Multimodal Graph Negative Learning

作者:
Zhengyu Wu↗Xu Wang↗Hongchao Qin↗Xunkai Li↗Guang Zeng↗Rong-Hua Li↗Guoren Wang↗

arXiv:2606.12863v1 Announce Type: new Abstract: Multimodal attributed graphs (MAGs) integrate graph topology with heterogeneous modality attributes, such as text and images, thereby enabling richer modeling of complex relational systems. However, such expressiveness also makes learning on MAGs depend on multiple semantic sources, including structural topology, textual and visual attributes, each of which can be regarded as a branch for node representation. Node-level branch semantic imbalance arises when these branches differ across nodes in semantic informativeness and reliability: a branch that provides discriminative semantics for one node may mislead another due to bias in modality quality or structural context. Existing methods often mitigate such heterogeneity through cross-branch agreement or alignment, implicitly treating the dominant prediction as reliable supervision. When the dominant branch is biased, forced imitation may propagate its bias to other branches and suppress original semantics that are useful for classification. We propose GraphMNL, a graph-aware multimodal negative learning framework that addresses this issue by using Negative Learning as cross-branch guidance. Instead of forcing inferior branches to imitate a teacher prediction, the model teaches them which classes a node is unlikely to belong to. GraphMNL builds a branch library, identifies dominant and inferior branches via graph-aware reliability arbitration, gates unstable transfer, and applies target-preserving negative learning over non-target classes. This design decouples target supervision from branch guidance so that supervised losses learn the correct class, while Negative Learning suppresses unlikely alternatives when branch agreement is unreliable. Through the comprehensive experimental evaluation, GraphMNL achieves the best performance on Grocery datasets with 72.47% accuracy and 76.60 F1 score on Reddit M datasets.

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24.
arXiv (CS.CV) 2026-06-11

Tac-DINO: Learning Vision-Tactile Features with Patch Alignment

作者:
Hong Li↗Yankang Dong↗Yue Xu↗Yihan Tang↗Mingzhu Li↗Jiamin Qiu↗Qihang Yao↗Xing Zhu↗Yujun Shen↗Nan Xue↗Yong-Lu Li↗

Touch is the primary medium through which humans interact with the environment. Currently, tactile learning mainly focuses on image-level pretraining or alignment. However, tactile signals correspond to local object contact, while research into scale alignment and holographic matching remains limited and proper datasets and benchmarks also lack. To bridge this gap, we first construct a data collection system to acquire a large-scale tactile dataset, with over 20 K tactile contacts from 505 real-world objects. Building on this dataset, we design a Vis-Tac Holographic Matching Benchmark to evaluate vision-tactile local-to-global alignment ability. Then we propose Vision-Tactile Patch Alignment (VTPA) methods for vision-tactile representation learning. Experiments demonstrate that these exceed the performance of methods without alignment and align with whole-object images.

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25.
arXiv (CS.CL) 2026-06-24

Exploring Language-Agnosticity in Function Vectors: A Case Study in Machine Translation

作者:
Nurkhan Laiyk↗Gerard I. G\'allego↗Javier Ferrando↗Fajri Koto↗

Function vectors (FVs) are vector representations of tasks extracted from model activations during in-context learning. While prior work has shown that multilingual model representations can be language-agnostic, it remains unclear whether the same holds for function vectors. We study whether FVs exhibit language-agnosticity, using machine translation as a case study. Across three decoder-only multilingual LLMs, we find that translation FVs extracted from a single English$\to$X direction transfer to other target languages, consistently improving the rank of correct translation tokens across multiple unseen languages. We further find that the highest-gain tokens span multiple languages and that translation FVs across directions share most of their top-ranked heads, indicating that the FV encodes a largely language-agnostic translation signal rather than a language-pair-specific mapping.

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