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01.

Nature (Science) 2026-06-17 DOI: HASH:d4cc74ca53d780ce0135bd64f678bc55

The EU needs to back its ambition to end animal testing with cash

作者: 未知作者

The European Union has declared that it wants to stop using animals in chemical safety testing. Its goal will need a timeline and a serious funding commitment. The European Union has declared that it wants to stop using animals in chemical safety testing. Its goal will need a timeline and a serious funding commitment.

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02.

arXiv (quant-ph) 2026-06-16 DOI: arXiv:2606.15061

VQE as Initial State Preparation for QPE on Heisenberg Spin-Glass Hamiltonians

作者:

Elijah Pelofske↗Stephan Eidenbenz↗

arXiv:2606.15061v1 Announce Type: new Abstract: Quantum Phase Estimation (QPE) is the quantum algorithmic workhorse for computing ground state energies of quantum Hamiltonians with quantum computers. Ground state energy calculation of physical systems is perhaps the most promising use case for quantum computing in terms of scientific and commercial value with a plausible path to outperformance of classical alternatives. This path, however, hinges on the availability of initial states for QPE with significant overlap with the true ground state. Using extensive (classical) numerical computations, we study whether the NISQ-era algorithm VQE (Variational Quantum Eigensolver) could be used to efficiently prepare high-overlap states of disordered fully-connected anisotropic Heisenberg spin glass quantum Hamiltonians with up to $15$ qubits. We find that (i) – consistent with widely held, but rarely numerically illustrated beliefs – VQE is generally unable to efficiently converge to the ground state for our Hamiltonians, which is a well-known issue with VQE due to a variety of factors including vanishing gradients and local minima; (ii) low energy states do not necessarily have large ground-state overlap, but there is typically a correlation between the two measures; (iii) adding more than three layers to the VQE ansatz neither improves overlap nor the energies found; and (iv) the best-found overlap scaling as a function of the Hamiltonian system size is not strongly exponentially decreasing, suggesting potential for VQE to be a heuristic state preparation algorithm for QPE.

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03.

arXiv (CS.CV) 2026-06-16 DOI: arXiv:2606.14777

JoyAI-VL-Interaction: Real-Time Vision-Language Interaction Intelligence

作者:

Dingyu Yao↗Junhao Zhou↗Chenxu Yang↗Chuanyu Qin↗Haowen Hou↗Zheming Liang↗Congcong Wang↗Yuhang Cao↗Shenglong Ye↗Shuai Xie↗Shuhuan Gu↗Haoyang Huang↗…

Many moments in the real world do not wait for a user to ask. A fire starts on a security monitor, an expression flickers across a video call, or a product a viewer wants flashes by in a livestream. Yet today's large models remain mostly turn-based by design: they answer only when addressed, and even video-call apps that appear interactive still operate as question-answer systems, reacting only when polled or prompted. We argue for a different paradigm: a model that is present in the world like a person. It continuously watches what is happening now, decides on its own whether to speak or stay silent, interacts in real time, and delegates to a background model when the problem is hard. To advance interaction models and their adoption across domains, we make two fully open-sourced contributions. First, we release JoyAI-VL-Interaction, an 8B-scale, vision-first VL-interaction model. The model makes the response decision internally, choosing each second to stay silent, respond, or delegate to a background model, and it excels at vision-triggered responsiveness and time awareness. We pair it with a transferable training recipe, from which capabilities we never trained for emerge, such as guiding a shopper through changing app screens or improvising a lecture from a slide deck. Second, we release a complete, deployable system built around that model. The system streams any ongoing video into the model, making it genuinely present in the world. All other components are pluggable, including ASR/TTS modules, memory, visualization UI, and a background brain that can connect to any API or agent. Across six real-world scenarios, human raters prefer JoyAI-VL-Interaction over the in-app video-call assistants of Doubao and Gemini by a wide margin. To our knowledge, this is the first open, vision-driven interaction model released together with its training recipe, data, and complete deployable system.

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04.

arXiv (CS.AI) 2026-06-19 DOI: arXiv:2606.19821

TelcoAgent: A Scalable 5G Multi-KPM Forecasting With 3GPP-Grounded Explainability

作者:

Geon Kim↗Dara Ron↗Sukhdeep Singh↗Suyog Moogi↗Pranshav Gajjar↗V V N K Someswara Rao Koduri↗Een Kee Hong↗Vijay K. Shah↗

arXiv:2606.19821v1 Announce Type: new Abstract: Key Performance Measurement (KPM) forecasting is essential for proactive network management of 5G and next-generation telecom networks. However, existing machine learning (ML) approaches face significant limitations in scalability and explainability, restricting their effectiveness in real-world deployments. We propose TelcoAgent, a foundation model-based framework that enables accurate, scalable, and explainable forecasting of multiple KPMs across diverse network cells without the need for site-specific training. Specifically, the framework comprises three key components: (i) an automated three-agent pipeline that constructs a 3rd Generation Partnership Project (3GPP) knowledge graph directly from specification documents, (ii) a scalable, time-series foundation model (TSFM)-based prediction pipeline to deliver accurate, zero-shot forecasting, and finally (iii) a reasoning and explanation pipeline that provides actionable, domain-grounded diagnostics. Evaluated using a 3-month, real-world, city-scale 5G KPM dataset from a U.S.-based network operator, TelcoAgent demonstrates high forecasting accuracy for all 7 considered KPMs per cell across 200 cells, while delivering explainable insights and actionable instructions to address network degradations.

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05.

arXiv (CS.CV) 2026-06-24 DOI: arXiv:2606.24457

Lite Any Stereo V2: Faster and Stronger Efficient Zero-Shot Stereo Matching

作者:

Junpeng Jing↗Ronglai Zuo↗Zhelun Shen↗Shangchen Zhou↗Rolandos Alexandros Potamias↗Stefanos Zafeiriou↗Krystian Mikolajczyk↗Jiankang Deng↗

Recent advances in stereo matching have achieved remarkable accuracy, but often rely on large models, heavy computation, or additional foundation-model priors, making them difficult to deploy on resource-constrained platforms. In contrast, efficient stereo models offer faster inference but are commonly considered less capable of strong zero-shot generalization. In this paper, we challenge this assumption by introducing Lite Any Stereo V2 (LAS2), an ultra-fast model series designed for efficient zero-shot stereo matching. LAS2 is developed from both architecture and training perspectives. Architecturally, we revisit efficient stereo design under practical deployment settings and propose a 2D-only cost aggregation framework, optimized for real inference latency rather than theoretical MACs alone. For training, we develop a three-stage strategy that combines synthetic supervision, self-distillation, and real-world knowledge distillation. To improve the reliability of real-world pseudo supervision, we further introduce pseudo-label filtering and an error-clamping operation, enabling smoother synthetic-to-real transfer. We instantiate LAS2 as a family of models, including feed-forward variants for different efficiency budgets and an iterative variant for higher accuracy. Extensive experiments show that LAS2 achieves state-of-the-art accuracy among efficient stereo methods while maintaining significantly lower latency. Specifically, LAS2-H achieves stronger overall zero-shot performance than the iterative method Fast-FoundationStereo, with 1.8x and 2.7x faster inference on H200 and Orin, respectively. The project page, demos, and code are available at https://tomtomtommi.github.io/LiteAnyStereoV2/.

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06.

arXiv (CS.LG) 2026-06-24 DOI: arXiv:2507.11768

LLMs are Bayesian, In Expectation, Not in Realization

作者:

Leon Chlon↗Fatima Sheaib↗Zein Khamis↗Maggie Chlon↗Mahdi El Zein↗MarcAntonio M. Awada↗

arXiv:2507.11768v3 Announce Type: replace-cross Abstract: Bayesian accounts of in-context learning face a direct objection: exact posterior predictives for exchangeable data are invariant to task-preserving order, yet transformers change next-token probabilities when the same examples are serialized differently. We show this objection targets a structural invariant rather than the quantity scoring online prediction. For any Bayesian reference, excess prequential code length is exactly cumulative predictive KL. For unordered support sets that must be serialized, the expected regret of a single admissible ordering decomposes into that of the order-averaged predictor plus an order-averaging gain. Exchangeability violations are therefore not binary refutations; they are priced by log loss. We instantiate the theory with KT/Dirichlet finite-alphabet prediction and coarsened Bayesian linear-regression (BLR) predictive distributions. On Qwen2.5-7B/14B, floored candidate distributions at support $256$ have one-step excess code lengths of $0.020/0.011$ bits for Bernoulli and $0.039/0.022$ bits for four-way categorical prediction, with candidate mass above $0.999$; coarsened BLR continuations increasingly match the posterior-predictive digit distribution as support grows. A frequentist plug-in baseline sharpens the reading: the predictive distributions sit closer to the Bayesian posterior predictive than to the maximum-likelihood plug-in, by a margin largest at small support, where the plug-in is degenerate, and vanishing as the references converge. Position interventions and a from-scratch ablation localize order sensitivity to the positional encoding, activation patching tests causal use of decoded sufficient statistics, and permutation mixtures quantify the downstream log-loss cost of arbitrary orderings. Transformers need not realize exchangeable posterior predictives for every serialization to be Bayes-competitive prequential predictors.

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07.

arXiv (quant-ph) 2026-06-24 DOI: arXiv:2606.24869

Rapid Cavity-Based Mid-Circuit Measurement and Feedforward in a Neutral Atom Array

作者:

Tsai-Chen Lee↗Jacquelyn Ho↗Yue-Hui Lu↗Tai Xiang↗Nathaniel B. Vilas↗Zhenjie Yan↗Dan M. Stamper-Kurn↗

arXiv:2606.24869v1 Announce Type: new Abstract: Measuring part of a quantum system in the midst of its evolution and acting on the result in real time is essential for numerous quantum information protocols. Neutral-atom arrays are a leading platform for quantum information processing, but their mid-circuit measurement-and-feedforward cycle times have remained slow, typically exceeding 1 ms. Here we demonstrate fast mid-circuit measurement and real-time feedforward in an array of atomic qubits coupled to a high-finesse optical cavity. Local light shifts tune individual data qubits out of resonance with the cavity, shielding their coherence, while a near-resonant probe drives a selected qubit whose emission is collected with Purcell enhancement. Mid-circuit measurements of four qubits with sub percent infidelity reduce the coherence of a fifth unmeasured data qubit by less than 2%. We implement real-time feedforward to correct measurement-induced phase shifts and to realize an adaptive circuit for optimal quantum state discrimination and conditional state preparation. Our approach reduces the measurement-and-feedforward cycle time to below 100 $\mu$s and establishes optical cavities as a route to fast control of neutral-atom quantum systems.

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08.

arXiv (CS.LG) 2026-06-17 DOI: arXiv:2601.10962

Noise-Driven Exploration and Transient Freezing Select Flat Minima in Stochastic Gradient Descent

作者:

Ning Yang↗Yikuan Zhang↗Qi Ouyang↗Chao Tang↗Yuhai Tu↗

arXiv:2601.10962v2 Announce Type: replace Abstract: Stochastic gradient descent (SGD) is central to deep learning, yet the dynamical origin of its preference for flatter, more generalizable solutions remains unclear. Here, by analyzing SGD learning dynamics, we identify a nonequilibrium mechanism that governs solution selection during training. Numerical experiments reveal a transient exploratory phase in which SGD trajectories repeatedly escape sharp valleys and migrate toward flatter regions of the loss landscape before becoming confined to a final basin. Using a tractable physical model, we show that SGD noise reshapes the loss landscape into an effective potential that preferentially stabilizes flat solutions. We further uncover a transient freezing mechanism: as training progresses, the flattening landscape suppresses transitions between competing valleys. Stronger SGD noise delays this freezing transition, prolonging the exploratory phase and thereby increasing the probability of convergence to flatter minima. Together, these results provide a unified physical framework connecting learning dynamics, loss-landscape geometry, and generalization, and suggest guiding principles for the design of more effective optimization algorithms.

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09.

arXiv (CS.CV) 2026-06-19 DOI: arXiv:2606.20140

SA-VIS: Sparse frame Annotations for training Video Instance Segmentation

作者:

Edoardo Mello Rella↗Ajad Chhatkuli↗Shipra Jain↗Ender Konukoglu↗Luc Van Gool↗

Recent online video instance segmentation (VIS) methods have achieved impressive results, thus becoming the preferred approach to segment instances in videos. Despite the resurgence of impressive single image models, the online (or semi-online) VIS approaches outperform single-image models (e.g., based on SAM) by using long sequences of densely annotated frames during training. However,such a training setup of VIS is expensive in the sense of compute as well as dense annotations required. In order to solve these major flaws, we argue that the effective modeling of the instances and their evolution in videos do not require densely annotated frames. To that end, we propose a simple and effective module, called Past-frames Feature Propagation (PFP) which aggregates low-dimensional features from the image encoder of multiple frames. This simple low-compute module provides tremendous learning capability in using sparse video frame labels for end-to-end training. Combined with a light-weight frame-specific Instance Queries, our Sparse frame Annotation VIS (SA-VIS) significantly improves performance over its baseline. Most interestingly, our simple design that avoids complexities effectively bridges the gap in accuracy between training on sparsely and densely annotated video sequences. This translates to a mere 0.4% drop in performance of SA-VIS when using annotations for only 1/5 of the images in the dataset. Empirically, SA-VIS shows strong improvements over the baseline on YouTube-VIS 2019/2021/2022 and Occluded VIS (OVIS) and an over 1% improvement in AP on the state-of-the-art in a limited annotations scenario.

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10.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.11976

Exploration Structure in LLM Agents for Multi-File Change Localization

作者:

Akeela Darryl Fattha↗Kia Ying Chua↗Lingxiao Jiang↗Laura Wynter↗

arXiv:2606.11976v1 Announce Type: cross Abstract: Software engineering tools increasingly rely on LLM based agents to localize files to change to resolve a software issue. Most AI agents explore repositories linearly, that is, visiting one directory or file per step. We postulate that this is a structural mismatch for changes that span several subsystems. We compare linear sequential exploration against non-linear, domain-scoped parallel agentic exploration. Using SWE Bench Pro as initial benchmark, we focus on ansible as an exemplar. We construct an approach for persistent-session evaluation of GitHub issues anchored at a single base commit. We compare our non-linear domain-agent file traversal system against a base LLM without direct repository access, a single agent Recursive Language Model (RLM) baseline with a persistent Python REPL and an external CLI baseline using Codex 5.5 High. Domain scoped parallel agent spawning with a small Haiku-class model achieves the highest micro F1 among Haiku class models by a large margin. Domain-agents is the second highest behind only the much larger Codex 5.5 High on our own expanded benchmark including over more recent PRs from 2025 and 2026. On the original, curated, 2020 SWE-bench Pro benchmark, a larger Sonnet plain LLM baseline attains higher micro F1 by predicting few files, leading to higher precision, but at significantly lower all gold recall. We also present three additional findings. First, documentation evolution is a latent dependency unresolved by any approach. Second, naive file system access can degrade localization driven by test-file over prediction. Lastly, forced multi-agent consultation does not measurably help and raises token cost substantially.

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11.

medRxiv (Medicine) 2026-06-22 DOI: HASH:51c9bb8db4069c1d2487eeaa0d9e0ca2

AI-driven Multimodal Representation Learning for Latent Mediation Structure Discovery of Socioeconomic Disadvantage, Psychosocial Factors, and Cardiometabolic Multimorbidity

作者:

Ma↗Cao↗

Social disadvantage is associated with multimorbidity, but the pathways linking social conditions to disease burden remain poorly understood. We developed an AI-driven multimodal mediation framework that integrates socioeconomic, psychosocial, clinical, laboratory, behavioral, and genomic data from the All of Us Research Program. Modality-specific variational autoencoders were used to derive latent representations of each data domain, and mediation analyses were subsequently performed in latent space to evaluate indirect associations between socioeconomic disadvantage, psychosocial factors, and multimorbidity. The final analytic cohort included 20,804 participants with complete multimodal data. Across 800 exposure–mediator–outcome combinations, mediation signals were concentrated within a small number of latent dimensions. The strongest indirect association linked a socioeconomic disadvantage dimension, a psychosocial vulnerability dimension, and a cardiometabolic multimorbidity dimension (NIE = 0.002517). The psychosocial dimension was characterized by poorer mental health, greater loneliness, lower social well-being, and lower health literacy, whereas the outcome dimension was associated with hypertension, diabetes, hyperlipidemia, obesity, chronic kidney disease, and heart disease. Bootstrap analyses supported the stability of the leading pathway. These findings suggest that psychosocial vulnerability may contribute to the association between socioeconomic disadvantage and cardiometabolic multimorbidity. More broadly, the proposed framework illustrates how AI-based representation learning can be used to investigate complex relationships across high-dimensional multimodal health data.

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12.

arXiv (CS.LG) 2026-06-24 DOI: arXiv:2606.20945

Grouped Query Experts: Mixture-of-Experts on GQA Self-Attention

作者:

Vishesh Tripathi↗Abhay Kumar↗

arXiv:2606.20945v2 Announce Type: replace Abstract: Self-attention is central to Transformer performance and is often the most expensive part of the Transformer at long context lengths because its pairwise token interactions scale quadratically with sequence length. Standard dense attention also applies the same set of attention heads to every token regardless of token difficulty or information content. This uniform activation can waste compute, especially as sequences grow longer and attention cost increases rapidly. We propose Grouped Query Experts (GQE), a mixture-of-experts layer on top of grouped-query attention (GQA). Within each GQA group, a router selects k query-head experts per token while all key-value (KV) heads remain dense and unchanged. Thus, GQE keeps the KV cache benefits of GQA and reduces only the active query-head computation. On a fixed 30B token budget at the 250M parameter scale, GQE matches the all-active GQA baseline in downstream accuracy while activating half the query heads per token.

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13.

arXiv (CS.CV) 2026-06-15 DOI: arXiv:2606.14071

ShearFuse-UNet: Hadamard, DCT, and Shearlet Transform Fusion for Next-Day Wildfire Spread Prediction

作者:

Ene Meco↗Yingyi Luo↗Emadeldeen Hamdan↗Adam Watts↗Ahmet Enis Cetin↗

We propose ShearFuse-UNet, a lightweight and computationally efficient deep learning model for next-day wildfire spread prediction from multi-modal satellite data. The model integrates three complementary transform-domain branches inside each encoder block of a U-Net backbone: a 2D Fast Walsh-Hadamard Transform (WHT) branch, a 2D Discrete Cosine Transform (DCT) branch, and a cone-adapted digital Shearlet residual branch. The WHT and DCT branches establish orthogonal latent spaces with learnable spectral scaling and fixed soft-thresholding, while the Shearlet branch provides anisotropic, multi-directional feature decomposition that explicitly encodes the elongated edge structures characteristic of fire fronts. A learned SpectralFusion gate adaptively combines the WHT and DCT responses, and the Shearlet reconstruction is added as a residual. This three-branch design bears a loose structural analogy to transformer self-attention: the WHT and DCT branches provide complementary spectral representations that are adaptively fused, while the Shearlet branch contributes directional content through a residual pathway. Unlike self-attention, the proposed design relies on fixed mathematical transforms rather than learned projection operators, reducing parameter count and computational cost. Evaluated on the WildfireSpreadTS dataset, ShearFuse-UNet achieves an F1 score of 0.596 with only 267k parameters, outperforming a ResNet18-based U-Net (14M parameters, F1 = 0.589) and demonstrating a highly favorable accuracy-efficiency trade-off. Results on the Google Next-Day Wildfire Spread dataset further validate these findings across a different benchmark.

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14.

arXiv (CS.AI) 2026-06-11 DOI: arXiv:2606.08102

Continual Quadruped Robots Coordination via Semantic Skill Discovery

作者:

Daoqing Wang↗Yuchen Xiao↗Weixuan Huang↗Zhilong Zhang↗Shenghua Wan↗Meng Li↗Lei Yuan↗Yang Yu↗

arXiv:2606.08102v2 Announce Type: replace-cross Abstract: Multi-quadruped coordination has attracted increasing attention due to its enhanced payload capacity, broader contact coverage, and improved adaptability to challenging tasks. Existing methods for multi-quadruped manipulation typically focus on predefined or closed task families, often relying on multi-agent reinforcement learning (MARL) to train task-specific coordination policies. However, such methods struggle in open-ended continual learning settings, where tasks arrive sequentially and robots are expected to acquire new coordination skills while reusing previously learned ones without catastrophic forgetting. To address this challenge, we propose Conquer, a semantic skill-library framework that formulates continual multi-quadruped coordination as a retrieve-adapt-update process. First, to accommodate varying team sizes across tasks, we design a team-structured Self-Allies-Goal (SAG) backbone that supports variable-cardinality robot teams by explicitly modeling each robot's own state, teammate context, and task goal. For each incoming task, Conquer constructs a task-level semantic descriptor from pre-execution information and retrieves a relevant skill from the library for adaptation. After successful execution, Conquer updates the skill library by extracting trajectory-level semantic descriptors and organizing them according to semantic distance, thereby enabling continual skill accumulation and cross-task knowledge transfer. Simulation experiments show that Conquer achieves a final average success rate of 95.6%, demonstrating strong forward transfer and negligible catastrophic forgetting. Real-world rollouts on Unitree Go2 teams further validate the deployment feasibility of Conquer for practical multi-quadruped coordination. Simulation and real-robot demonstration videos are available at: https://conquer-project.pages.dev/.

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15.

arXiv (CS.AI) 2026-06-16 DOI: arXiv:2606.15052

PANDA: An LLM-Enhanced Performance-Driven Analog Design Framework Bridging Design Intent and Layout Generation

作者:

Haoyi Zhang↗Weijian Fan↗Xiaohan Gao↗Bingyang Liu↗Runsheng Wang↗Yibo Lin↗

arXiv:2606.15052v1 Announce Type: cross Abstract: Traditional design of analog circuits heavily relies on manual interventions across topology, sizing, and layout, with prior automation addressing stages in isolation. In this work, we propose PANDA, an LLM-enhanced framework that bridges high-level design intent to final layout by actively managing cross-stage dependencies through guided topology synthesis, substructure-aware sizing, and constraint-driven layout generation. This shifts automation from algorithm-centric execution to intent-centric co-design, reducing turnaround time from days or weeks to hours while improving design performance.

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16.

arXiv (CS.LG) 2026-06-11 DOI: arXiv:2606.11676

Neural-Parameterized Cellular Automata for Wildfire Spread

作者:

Maksym Zhenirovskyy↗Ion Matei↗Rohit Vuppala↗Takuya Kurihana↗Hon Yung Wonga↗

arXiv:2606.11676v1 Announce Type: cross Abstract: Traditional wildfire models rely on rigid, low-dimensional parameters and static fuel maps, frequently underpredicting fire spread. To address this weakness, we introduce a hybrid deep-learning parameterized Probabilistic Cellular Automata (CA) framework implemented in JAX. Our approach employs a Multi-Scale Convolutional Neural Network to dynamically generate spatially varying parameters that govern fire-spread probability, wind alignment, and slope influence. This hybrid design captures complex, nonlinear environmental interactions while preserving the physical interpretability of the underlying three-state CA. The JAX implementation enables hardware acceleration and gradient-based parameter calibration. Evaluated on six large-scale wildfires in the western United States, the model maintains IoU > 0.6 over 72-hour forecast horizons after a 10-day data assimilation window during which the model is fitted incrementally to observed perimeters; the resulting forecast is a conditional projection of fire growth under the suppression regime already ncoded in those observations.

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17.

arXiv (CS.AI) 2026-06-12 DOI: arXiv:2606.13197

ARMOR-MAD: Adaptive Routing for Heterogeneous Multi-Agent Debate in Large Language Model Reasoning

作者:

Fuqiang Niu↗Bowen Zhang↗

arXiv:2606.13197v1 Announce Type: new Abstract: Multi-agent debate (MAD) can improve large language model reasoning, but fixed debate pipelines often waste computation and can amplify correlated errors among similar agents. We propose ARMOR-MAD, a training-free heterogeneous MAD framework that treats debate as conditional computation. ARMOR-MAD combines three components: Pre-debate Agreement Routing (PAR) decides whether independently generated Round-0 answers require debate; Early Agreement Stopping Evaluator (EASE) stops debate after convergence; and Semantic Outlier Detection (SOD) down-weights abnormal final answers during aggregation. Across MATH Level 5, GSM8K, MMLU, and MMLU-Pro, ARMOR-MAD consistently improves over fixed-round heterogeneous debate with the same model pool, reaching 65.5\%, 96.5\%, 90.0\%, and 81.5\% accuracy, respectively. The results suggest that genuine model heterogeneity and agreement-based control are both important for making MAD more accurate and efficient.

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18.

Nature Biotechnology 2026-06-23 DOI: HASH:bce4556c1376de90e4df808a3e58ef5c

Mapping and engineering the human cell–cell interactome

作者:

Dino Di Carlo↗

Efforts to systematically understand how cell interactions tune tissue-level function have motivated transformative advances in single-cell transcriptomics and spatial profiling. Although these technologies can measure molecular states in individual cells and their spatial mapping within tissues, they also reveal that there exists a fundamental knowledge gap of how cells influence each other in context. In this Perspective, we propose an initiative to map and engineer the human cell–cell interactome: a functional atlas of how all major human cell types communicate. We highlight how recent innovations can make this vision achievable. As a first moonshot, we propose the ‘Billion Cell×Cell Project’, which systematically characterizes the outcomes of defined cell–cell dyads across diverse cell types and conditions. We envision this multistage initiative will produce progressively deeper insights and unlock additional avenues for therapeutic discovery. We call on the scientific community to join us in building the tools, datasets and models that will decode and rewrite the language of life between cells. Di Carlo and colleagues discuss technologies required to map and engineer the human cell–cell interactome and the therapeutic avenues such an atlas could unlock.

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19.

bioRxiv (Bioinfo) 2026-06-18 DOI: HASH:f3275753c51d0f7e10fc0d38c3a75723

MorphoStat: A Statistics-Aware Pipeline for Morphological Profiling Analysis

作者:

Altobi↗Heo↗

High-content imaging produces thousands of morphological measurements per cell. Interpreting these measurements requires normalization to remove plate effects, statistical tests selected on the basis of data distribution, and control over false discoveries across many features tested at once. MorphoStat is an open-source Python pipeline that applies this sequence of steps automatically. Given a CSV file from CellProfiler or a compatible imaging platform, it removes low-quality wells, normalizes each plate against DMSO controls using a MAD-scaled z-score, routes each feature to a parametric or nonparametric test based on a distributional check, applies Benjamini Hochberg correction, and writes out results and publication-ready figures. On the BBBC021 benchmark (MCF-7 breast-cancer cells, 632 wells, 473 features), MorphoStat recovered 12 of 13 known mechanism-of-action classes in principal component space, confirming that the normalization and statistical routing work as intended. The tool is available at https://github.com/Almunthir334/morphostat (DOI: 10.5281/zenodo.20354069) under the MIT license.

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20.

arXiv (CS.LG) 2026-06-16 DOI: arXiv:2603.14709

Not All Retrievals are Useful: Cross-Attention for Input-Aware RAG in Time Series Forecasting

作者:

Seunghan Lee↗Jaehoon Lee↗Jun Seo↗Sungdong Yoo↗Minjae Kim↗Tae Yoon Lim↗Dongwan Kang↗Hwanil Choi↗SoonYoung Lee↗Wonbin Ahn↗

arXiv:2603.14709v2 Announce Type: replace Abstract: Retrieval-augmented generation (RAG) enhances zero-shot time series (TS) forecasting by leveraging external knowledge bases, yet existing approaches overlook input-level relevance when fusing retrieved samples with the query. We argue that not all retrievals are equally useful, and irrelevant ones can degrade performance. To this end, we propose Cross-RAG, a zero-shot RAG-based forecasting framework that selectively attends to query-relevant retrieved samples via query–retrieval cross-attention. By modeling input-level relevance between the query and retrieved samples, Cross-RAG jointly incorporates three sources of information: 1) the query itself, 2) the retrieved samples, and 3) their relational interactions. In particular, this input-aware design enables Cross-RAG to remain stable as the number of retrieved samples $k$ grows, whereas prior methods without cross-attention require careful $k$ tuning to avoid degradation from irrelevant retrievals. Extensive experiments demonstrate that Cross-RAG consistently improves zero-shot forecasting performance across multiple TSFM backbones and various RAG methods, with additional analyses confirming its effectiveness across various retrieval scenarios. Code is available at https://github.com/seunghan96/cross-rag/.

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21.

arXiv (CS.LG) 2026-06-16 DOI: arXiv:2502.17614

Scalable Graph Condensation with Evolving Capabilities

作者:

Shengbo Gong↗Mohammad Hashemi↗Juntong Ni↗Carl Yang↗Wei Jin↗

arXiv:2502.17614v3 Announce Type: replace Abstract: The rapid growth of graph data creates significant scalability challenges as most graph algorithms scale quadratically with size. To mitigate these issues, Graph Condensation (GC) methods have been proposed to learn a small graph from a larger one, accelerating downstream tasks. However, existing approaches critically assume a static training set, which conflicts with the inherently dynamic and evolving nature of real-world graph data. This work introduces a novel framework for continual graph condensation, enabling efficient updates to the distilled graph that handle data streams without requiring costly retraining. This limitation leads to inefficiencies when condensing growing training sets. In this paper, we introduce GECC (\underline{G}raph \underline{E}volving \underline{C}lustering \underline{C}ondensation), a scalable graph condensation method designed to handle large-scale and evolving graph data. GECC employs a traceable and efficient approach by performing class-wise clustering on aggregated features. Furthermore, it can inherit previous condensation results as clustering centroids when the condensed graph expands, thereby attaining an evolving capability. This methodology is supported by robust theoretical foundations and demonstrates superior empirical performance. Comprehensive experiments including real world scenario show that GECC achieves better performance than most state-of-the-art graph condensation methods while delivering an around 1000$\times$ speedup on large datasets.

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22.

arXiv (CS.CL) 2026-06-24 DOI: arXiv:2606.24460

The African Language Tax: Quantifying the Cost, Latency, and Context Penalty of Tokenizing African Languages in Frontier LLMs

作者:

Olaoye Anthony Somide↗

Commercial large language models bill, scale latency, and budget context per token. Yet tokenizers assign more subword tokens to the same meaning in some languages than in others, so speakers of languages with high token-fertility pay a structural penalty before a model is ever invoked. This penalty is documented for multilingual settings in general, but it has not been measured systematically for African languages at the level of enterprise deployment economics and cognitive context capacity. We measure it across 20 African languages spanning five language families and three scripts (Latin, Ge'ez/Ethiopic, N'Ko; 19 appear in the primary FLORES-200+ corpus, with Nigerian Pidgin measured via MAFAND-MT only), using parallel corpora so that the language effect is isolated from content. Across 11 frontier and open tokenizers on FLORES-200+, every African language carries a tokenization premium above English (median 1.88x on GPT-5 / o200k_base, up to 8.92x for N'Ko); the penalty is largest for Ethiopic and N'Ko scripts (reaching 7-9x) and is near-invariant across corpora (FLORES vs SIB-200 Pearson r = 0.9998). Translated into deployment terms, this results in up to 8.9x inference cost and an equivalent generation-latency multiplier (N'Ko vs English on GPT-5; 7.4x for Amharic), and as little as 11% of English's effective context window. The best currently available tokenizer for African languages, Gemma 4, reduces the mean premium from 3.31x (cl100k_base) to 2.38x, but no tokenizer eliminates the penalty. We release an open measurement tool (afri-fertility), a public leaderboard, a results dataset, and mitigation guidance for African builders. The penalty falls hardest on the languages whose speakers can least afford it, a digital divide encoded directly into the subword vocabulary.

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23.

arXiv (quant-ph) 2026-06-24 DOI: arXiv:2606.24312

Universal Extraction of Quantum Critical Exponents and Phase Transitions via Tailored Hilbert Space

作者:

Ye Xiong↗

arXiv:2606.24312v1 Announce Type: cross Abstract: Finite-size scaling and the renormalization group form the central toolkit for analyzing quantum phase transitions (QPTs). In this Letter, we introduce a novel Hilbert-space tailoring scheme to probe quantum critical phenomena. Applied to the second-order QPT of the one-dimensional (1D) XY model, our method yields precise critical points and exponents on lattices containing merely 50 unit cells. We further establish the universal applicability of this framework via investigations of the Berezinskii-Kosterlitz-Thouless transition in the 1D XXZ chain: critical parameters are recovered with as few as 12 lattice sites. This technique may open an alternative, efficient route to universally characterize QPT across many-body lattice systems.

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24.

arXiv (CS.LG) 2026-06-11 DOI: arXiv:2606.09744

Learning Dynamics Reveal a Hierarchy of Weight-Induced Layerwise Gram Metrics

作者:

Claudio Nordio↗

arXiv:2606.09744v3 Announce Type: replace Abstract: We study feed-forward ReLU networks with fixed readout and quadratic loss. The aim is to rewrite gradient descent not primarily as a dynamics in weight space, but as a collective dynamics closed in terms of fields defined on the training-set space. For a single hidden layer, the weight variables can be eliminated from the activation dynamics, yielding a closed equation for the residuals governed by a collective kernel that factorizes into an input-geometric matrix and a dynamical co-activation matrix. For deeper networks, the residual dynamics retains a clean layer-wise kernel structure. However, from depth three onward, closure requires a hierarchy of weight-induced Gram operators that mediate information transport across layers. Moreover, the conjugate-field dynamics is governed by operators satisfying a backward pullback recursion, of which the weight-induced Gram operators are the first nontrivial instances.

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25.

arXiv (CS.AI) 2026-06-18 DOI: arXiv:2507.04219

Model Collapse Is Not a Bug but a Feature in Machine Unlearning for LLMs

作者:

Yan Scholten↗Sophie Xhonneux↗Leo Schwinn↗Stephan G\"unnemann↗

arXiv:2507.04219v5 Announce Type: replace-cross Abstract: Current unlearning methods for LLMs optimize on the private information they seek to remove by incorporating it into their fine-tuning data. We argue this not only risks reinforcing exposure to sensitive data, but also fundamentally contradicts the principle of minimizing its use. As a remedy, we propose a novel unlearning method-Partial Model Collapse (PMC), which does not require unlearning targets in the unlearning objective. Our approach is inspired by recent observations that training generative models on their own generations leads to distribution collapse, effectively removing information from model outputs. Our central insight is that model collapse can be leveraged for machine unlearning by deliberately triggering it for data we aim to remove. We theoretically analyze that our approach converges to the desired outcome, i.e. the model unlearns the data targeted for removal. We empirically demonstrate that PMC overcomes four key limitations of existing unlearning methods that explicitly optimize on unlearning targets, and more effectively removes private information from model outputs while preserving general model utility. Overall, our contributions represent an important step toward more comprehensive unlearning that better aligns with real-world privacy constraints. Code available at https://www.cs.cit.tum.de/daml/partial-model-collapse/.

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