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01.
arXiv (CS.CV) 2026-06-25

Generalised Medical Phrase Grounding

Medical phrase grounding (MPG) maps textual descriptions of radiological findings to corresponding image regions. These grounded reports are easier to interpret, especially for non-experts. Existing MPG systems mostly follow the referring expression comprehension (REC) paradigm and return exactly one bounding box per phrase. Real reports often violate this assumption. They contain multi-region findings, non-diagnostic text, and non-groundable phrases, such as negations or descriptions of normal anatomy. Motivated by this, we reformulate the task as generalised medical phrase grounding (GMPG), where each sentence is mapped to zero, one, or multiple scored regions. To realise this formulation, we introduce the first GMPG model: MedGrounder. We adopted a two-stage training regime: pre-training on report sentence–anatomy box alignment datasets and fine-tuning on report sentence–human annotated box datasets. Experiments on PadChest-GR and MS-CXR show that MedGrounder achieves strong zero-shot transfer and outperforms REC-style and grounded report generation baselines on multi-region and non-groundable phrases, while using far fewer human box annotations. Finally, we show that MedGrounder can be composed with existing report generators to produce grounded reports without retraining the generator.

02.
arXiv (CS.LG) 2026-06-19

Algebraic Dead Directions in LayerNorm Transformers: A Forward-Pass-Only Diagnostic at LLM Scale

arXiv:2606.19491v1 Announce Type: new Abstract: Pretrained transformers sit near singular minima of the loss, where the Fisher information metric degenerates along dead directions: directions in parameter space along which the directional Fisher vanishes. Locating such a direction normally needs a forward pass and an eigendecomposition of activations, or a sampling-based complexity estimate; none returns a direction computable from the network's parameters alone. We give one, for LayerNorm transformers. The inverse-scale direction $\gamma^{-1}/\|\gamma^{-1}\|$ of the LayerNorm affine is an exact algebraic kernel of the post-final-norm centred activation covariance, for any input distribution, and induces a corresponding dead direction in parameter space. It is read from the LN scale parameter alone, with no forward or backward pass and no eigensolve: the cheapest dead-direction read, specific to LayerNorm. We test it on $14$ pretrained transformers ($9$ LayerNorm, $5$ RMSNorm; $160$M-$35$B; language and vision objectives). At random initialisation the predicted direction matches the measured bottom singular direction (one forward pass, direct SVD) to four decimal places on $9/9$ LayerNorm models, and is correctly absent on $5/5$ RMSNorm models, which lack the mean-subtraction projector that creates it. On the trained checkpoint the covariance eigenvalue along this direction deepens by ${\sim}10^3\times$ and further dead directions open; the random-init-to-trained gap is a one-forward-pass, per-checkpoint readout of singular structure along the predicted coordinate. Two consequences follow in closed form: the residual stream's smallest singular value is preserved block-to-block on $13/14$ transformers measured on their own input distribution, the one exception (Gemma$4$-$31$B) a genuine dead direction the same read pinpoints; and the kernel direction's presence classifies a transformer's normalisation from the parameters alone.

03.
arXiv (CS.AI) 2026-06-25

ReviewGuard: Aligning LLM-Assisted Peer Review with Long-Term Scientific Impact

arXiv:2606.24892v1 Announce Type: cross Abstract: Peer review is central to scientific quality control, yet it can undervalue papers that later achieve substantial citation impact. While frontier large language models have shown promise in automating aspects of peer review, they primarily mimic human reviewer preferences rather than predict long-term scientific value. We introduce ReviewGuard, a two-stage framework that aligns LLM-generated reviews with citation-based estimates of long-term scientific impact rather than contemporaneous reviewer judgments. On 20,861 AI/ML papers from OpenReview augmented with Semantic Scholar citation data, ReviewGuard achieves a Spearman correlation of \r{ho} = 0.776 with future citations on rejected-then-published papers, outperforming human reviewers (\r{ho} = 0.492) and a supervised Expert model (\r{ho} = 0.681). Under the same decision threshold, ReviewGuard flags 10.2% of high-impact rejected papers, compared with 1.8% for human reviewers, corresponding to a 5.6x improvement. Our results demonstrate that impact-aligned reinforcement learning can provide editors with a complementary signal for identifying high-potential work, without replacing human judgment.

04.
arXiv (CS.CL) 2026-06-16

Benchmarking LLM Agents on Meta-Analysis Articles from Nature Portfolio

Meta-analysis is a demanding form of evidence synthesis that combines literature retrieval, PI/ECO-guided study selection, and statistical aggregation. Its structured, verifiable workflow makes it an ideal substrate for evaluating systematic scientific reasoning, yet existing benchmarks lack ground truth across the full retrieval-screening-synthesis pipeline. We introduce MetaSyn, a dataset of 442 expert-curated meta-analyses from Nature Portfolio journals. Each entry pairs a research question with PI/ECO criteria, a retrieval corpus of 140k PubMed articles, verified positive studies, hard negatives that are topically similar but PI/ECO-ineligible, and complete search strategies and date bounds. Benchmarking twelve pipeline configurations (nine RAG variants and a protocol-driven agent) reveals a critical screening bottleneck: despite a retrieval ceiling of 90.9% recall at K=200, no system recovers more than 52.7% of ground-truth included literature. Current LLMs fail to reliably separate eligible studies from PI/ECO-failing distractors in pools of comparable topical relevance. Stage-attributed metrics capture where systems succeed and fail; a single end-to-end score does not.

05.
arXiv (CS.AI) 2026-06-16

Explainable deep learning improves human mental models of self-driving cars

arXiv:2411.18714v3 Announce Type: replace-cross Abstract: Self-driving cars increasingly rely on deep neural networks to achieve human-like driving. The opacity of such black-box planners makes it challenging to accurately anticipate when they will fail, with potentially catastrophic consequences. While research into interpreting these systems has surged, most of it is confined to simulations or toy setups due to the difficulty of real-world deployment, leaving the practical utility of such techniques unknown. Here, we introduce the Concept-Wrapper Network (CW-Net), a method for faithfully explaining the behavior of machine-learning-based planners that causally grounds their reasoning in human-interpretable concepts without sacrificing performance. We deploy CW-Net on a real self-driving car and show that the resulting explanations improve the human driver's mental model of the vehicle, allowing them to better predict its behavior, particularly in surprising situations. This demonstrates that explainable deep learning integrated into self-driving cars can be both understandable and useful in a realistic deployment setting. We anticipate our method could be applied to other safety-critical systems, such as autonomous drones and robotic surgeons, as well as to other architectures, such as end-to-end learning systems and vision-language-action models. Overall, our study establishes a deployment-validated pathway to interpretability for autonomous agents, which could help make them more transparent and safe.

06.
Nature Biotechnology 2026-06-19

Efficient site-specific gene addition using R2 retrotransposons in tobacco and rice

作者:

Precise integration of multikilobase DNA fragments remains a major technical barrier in plants. Here we introduce non-long terminal repeat (non-LTR) R2 retrotransposons as a versatile system for targeted gene integration in plants. We reconstituted R2 activity in Nicotiana benthamiana and benchmarked insertion efficiency and fidelity using a TMV-based episomal reporter system. We demonstrate site-specific integration of GFP (2.2 kb) and recombinase-compatible landing pads (0.6 kb) into 28S rDNA arrays, with intact cassette insertion frequencies up to 75% and 53%, respectively. To temporally constrain donor availability and avoid DNA intermediates, we combined in planta effector expression with recombinant RNA virus-mediated donor delivery. We apply R2 retrotransposons for targeted insertion of resistance cassettes within the rDNA of rice callus, achieving integration efficiencies up to 17%. These results position R2 retrotransposons as a double-strand break-free system for RNA-templated insertion of multikilobase gene cassettes at rDNA loci, for safe-harbor trait stacking in plants with potential applications in crop improvement and synthetic biology. Retrotransposons are applied in plants for safe-harbor transgene integration.

07.
arXiv (CS.CV) 2026-06-17

Qwen-RobotManip Technical Report: Alignment Unlocks Scale for Robotic Manipulation Foundation Models

Foundation models in language and multimodality achieve strong generalization by aligning heterogeneous data under a unified formulation and training at scale. In this report, we investigate whether this scaling recipe can be applied to robotic manipulation to achieve genuine generalization. This is challenging because, unlike text, manipulation data is heterogeneous by nature, expensive to collect, and narrow in diversity, making alignment and scale simultaneously difficult. We present Qwen-RobotManip, a generalizable Vision-Language-Action foundation model built on Qwen-VL. Qwen-RobotManip introduces a unified alignment framework across the representation, motion, and behavioral dimensions of manipulation, making large-scale multi-source training coherent rather than conflicting. This alignment capability in turn enables Qwen-RobotManip to absorb manipulation data at a scale that prior training regimes could not sustain. A human-to-robot synthesis pipeline converts egocentric hand demonstrations into robot trajectories across 15 platforms, and a rigorous curation pipeline harmonizes heterogeneous datasets. Using only open-source datasets and human videos without proprietary data collection, Qwen-RobotManip constructs a ~38,100-hour pretraining corpus and exhibits emergent generalization capabilities, including zero-shot instruction following, robustness to perturbations, reactive error recovery, and cross-embodiment transfer. We find that standard benchmarks fail to capture pretraining quality and instead adopt OOD settings including RoboCasa365, LIBERO-Plus, EBench, RoboTwin-Clean2Rand, RoboTwin-IF, and RoboTwin-XE. Qwen-RobotManip substantially outperforms prior state-of-the-art models, including $\pi$0.5, across all OOD settings, ranks 1st in RoboChallenge with a 20% relative improvement, and is validated on real-robot platforms including AgileX ALOHA, Franka, UR, and ARX.

09.
arXiv (CS.CV) 2026-06-18

Motion-Focused Latent Action Enables Cross-Embodiment VLA Training from Human EgoVideos

Training generalist Vision-Language-Action(VLA) models typically requires massive, diverse robotic datasets with high-fidelity action annotations. While egocentric human manipulation videos are abundant and capture significant environmental diversity, the absence of action labels makes them difficult to use in conventional training paradigms. To address this, we propose a latent-action-based framework designed to extract general action priors from unlabeled human videos. The architecture features a Hybrid Disentangled VQ-VAE that decouples motion dynamics from environmental backgrounds through physical masks, enabling the construction of a cross-embodiment action codebook. By pre-training on human videos with the codebook, the VLM backbone learns deep representations of action intent. For adaptation to specific embodiments, we introduce an intent-perception decoupling strategy where the VLM predicts the action intent while a separate frozen visual encoder provides state-specific features to the action expert, thereby reducing action hallucinations. Results in simulation and real-world environments show that our method, pre-trained exclusively on unlabeled human videos, performs competitively with state-of-the-art VLA models trained on massive annotated datasets, requiring only 50 trajectories for downstream adaptation.

10.
arXiv (CS.CV) 2026-06-25

Taxonomy-aware deep learning for hierarchical marine species classification in underwater imagery

Automated classification of marine species from underwater imagery is essential for scalable ocean biodiversity monitoring and conservation policy. Existing approaches struggle with severe domain shift across collection platforms, fine-grained visual similarity between closely related species, and uneven annotation granularity, where many specimens can only be identified to genus or a coarser taxonomic rank. We present a taxonomy-aware deep learning framework that aligns both the training loss and the inference rule with the hierarchical structure of biological classification, combining a taxonomy-weighted loss, minimum-risk Bayesian inference, multi-scale feature encoding, and independent per-rank classification heads. Evaluated on the FathomNet 2025 dataset1 (79 marine classes across seven taxonomic ranks), the system achieves a mean taxonomic distance of 1.581, within 3% of the 1st-place solution (1.535), with the largest gains from metric-aligned inference and simple, decoupled components that generalize better than learned dependencies under distribution shift.

11.
arXiv (CS.CV) 2026-06-24

Open-Vocabulary BEV Segmentation with 3D-Aware Geometric Constraints

Bird's-eye view (BEV) perception fuses multi-camera images into a unified top-down representation for autonomous driving. Despite recent progress, state-of-the-art methods remain confined to closed-set scenarios, making them vulnerable to unpredictable real-world environments. In this work, we introduce open-vocabulary BEV segmentation (OVBS), which leverages vision-language models (VLMs) to recognize categories beyond the training set while maintaining precise BEV perception and real-time efficiency. A key challenge in OVBS lies in the 3D geometric inconsistency inherent in the ill-posed lifting of 2D VLM semantics into BEV. To address this, we propose OVBEVSeg, a geometry-aware OVBS framework that enhances efficient Gaussian splatting (GS)-based unprojection by leveraging robust 3D geometric constraints across three progressive stages: (1) 2D-to-BEV pseudo-labeling via reliable 3D projection for OV generalization; (2) joint 2D-BEV per-scene optimization with BEV structural constraints for 3D geometric consistency; and (3) 3D geometric distillation for online efficiency. On the nuScenes dataset, OVBEVSeg achieves state-of-the-art performance, outperforming closed-set methods by 15.3 mIoU on unseen categories. Remarkably, even with no novel-class ground-truth labels, it remains competitive with self- and semi-supervised baselines trained with up to 40% of ground-truth annotations. Furthermore, it achieves 2.5x faster inference with only 0.22x the memory consumption of projection-based methods. Project page: https://hchoi256.github.io/projects/ovbevseg/.

12.
arXiv (CS.CL) 2026-06-17

PACE-RAG: Patient-Aware Contextual and Evidence-Constrained RAG for Clinical Drug Recommendation

Drug recommendation requires a deep understanding of individual patient context, especially for complex conditions like Parkinson's disease. While LLMs possess broad medical knowledge, they fail to capture the subtle nuances of actual prescribing patterns. Existing RAG methods also struggle with these complexities because guideline-based retrieval remains too generic and similar-patient retrieval often replicates majority patterns without accounting for the unique clinical nuances of individual patients. To bridge this gap, we propose PACE-RAG (Patient-Aware Contextual and Evidence-Constrained RAG). Rather than directly copying frequent medications from retrieved patients, PACE-RAG personalizes recommendations by first extracting patient-specific clinical features, retrieving cases around these features, and then refining the final prescription using the patient's current symptoms, active medication history, and focus-specific prescribing tendencies. By analyzing treatment patterns tailored to specific clinical features, PACE-RAG generates patient-specific medication recommendations along with an explainable clinical summary. Evaluated on a Parkinson's cohort and the MIMIC-IV benchmark using Llama-3.1-8B and Qwen3-8B, PACE-RAG achieved state-of-the-art performance, reaching F1 scores of 80.84% and 47.22%, respectively. These results suggest that PACE-RAG is a robust and clinically grounded framework for personalized decision support. Our code is available at: https://github.com/ChaeYoungHuh/PACE-RAG.

13.
arXiv (CS.AI) 2026-06-24

An Introduction to Causal Reinforcement Learning

arXiv:2606.24160v1 Announce Type: new Abstract: Causal inference provides a set of principles and tools that allow one to combine data and knowledge about an environment to reason with questions of counterfactual nature, i.e., what would have happened had reality been different, even when no data of this unrealized reality is currently available. Reinforcement learning provides methods to learn a policy that optimizes a specific measure (e.g., reward, regret) when the agent is deployed in an environment and pursues an exploratory, trial-and-error approach. These two disciplines have evolved independently and with virtually no interaction between them. We note that they operate over different aspects of the same building block, counterfactual relations, which makes them umbilically connected. Based on these observations, novel learning opportunities arise when this connection is explicitly acknowledged and mathematized. To realize this potential, we note that any environment where the RL agent is deployed can be decomposed as a collection of autonomous mechanisms with different causal invariances, parsimoniously modeled as a structural causal model; any standard RL setting implicitly encodes such a model. This formalization allows us to put under a unifying treatment different modes of learning, including online, off-policy, and causal calculus learning, which appear unrelated in the literature. However, these modalities are not exhaustive: we introduce several natural and pervasive classes of learning settings that entail novel dimensions of analysis. Specifically, we introduce and discuss through causal lenses generalized policy learning, where to intervene, imitation learning, and counterfactual learning. These tasks lead to a broader view of counterfactual learning and suggest great potential for studying causal inference and reinforcement learning side by side, which we call causal reinforcement learning (CRL).

14.
arXiv (quant-ph) 2026-06-16

Enhancing Quantum Machine Learning with Anyons

arXiv:2606.16090v1 Announce Type: new Abstract: The power of quantum computing and quantum machine learning relies on harnessing uniquely quantum phenomena as computational resources. While superposition, coherence and entanglement have been central to this effort, the role of particle exchange statistics remains largely unexplored. Here, we introduce a quantum kernel framework that unifies bosonic, fermionic, and anyonic (fractional) exchange statistics within a single learning paradigm. We study this family of kernels from three perspectives. At the representation level, Haar-averaged effective-dimension analysis shows that fractional exchange phases access feature-space directions inaccessible to the purely symmetric or antisymmetric limits. At the level of kernel geometry, the corresponding Gram matrices show greater separation from the distinguishable-particle baseline and reduced label-dependent model complexity. Finally, on learning benchmarks, anyonic kernels consistently outperform their bosonic and fermionic counterparts, with stronger target alignment and more favorable class geometry. Together, these findings show that exchange statistics reshape the structure and geometry of quantum feature space, leading to enhanced learning performance. Our work identifies particle exchange statistics as an overlooked computational ingredient for quantum machine learning and provides the first systematic comparison of quantum learning models across exchange phases.

15.
arXiv (CS.CL) 2026-06-12

Low-Latency Real-Time Audio Game Commentary System via LLM-Based Parallel Text Generation

We present a low-latency real-time audio game commentary system that generates spoken commentary directly from live gameplay video. In this end-to-end setting, a key bottleneck is accumulated waiting time; conventional pipelines capture frames, generate text, and synthesize speech sequentially for each utterance, and do not request the next generation until speech playback has completed. This strict sequentiality causes long and unnatural silence between utterances. To address this latency bottleneck, our system runs text generation in parallel with speech playback and buffers multiple candidate utterances ahead of time, enabling immediate synthesis at playback boundaries. Experiments on fast-paced game videos show that our parallel design reduces the mean inter-utterance silence from 9.6 seconds to 0.3 seconds compared to sequential baselines. It also improves similarity to professional speaking–silence timing patterns by over 40 %, and a user study with 120 experienced game players confirms significantly improved perceived speaking rhythm. Our demo video is available at: https://youtu.be/pmrRUlvav8M.

16.
medRxiv (Medicine) 2026-06-23

Social networks and their association with quality of life among older adults in rural Burkina Faso

Objective: This study aimed to identify the types of social networks present among older adults in a rural, low-income country setting and describe their association with quality of life (QoL). Methods: A population-representative, cross-sectional survey was conducted in 60 villages around Nouna in Burkina Faso from July to August 2021. Data were collected from resident adults aged 40 years and older. Variables captured were sociodemographic status; social network characteristics (using the Practitioner Assessment of Network Typology (PANT)); quality of life (using the EuroHIS-8 tool); presence of non-communicable diseases, mental health conditions, and disability. Additionally, social networks were broadly categorised as aggregated integrated and aggregated less-integrated groups. Social network types and the groups were described separately, and a multivariable linear regression model was used to understand the association between social network types and QoL, adjusted for sociodemographic and morbidity factors. Results: Among the 2390 respondents, median age was 55 yrs (IQR: 47-64 yrs) and 55.8% were female. Locally Integrated (35.4%) or Family Dependent (30.3%) were the most common PANT social network types, followed by a mixed group (having characteristics of two or more social network types) (30.5%). Private Restricted (2.1%), Locally Self-Contained (1.2%), and Wider Community-Focussed (0.4%) types were uncommon. Adults with aggregated integrated network groups (36.1%) and aggregated less-integrated group (36.0%) were near equal, while others were non-aggregable. Although Wider Community-Focused type showed a significantly better QoL ({beta}= 8.69, 95%CI: 4.10 to 13.27), the association between social networks and QoL were subdued when controlled for morbidity factors, and hence no significant associations were observed between other types or the aggregated groups. Conclusion: Although having integrated social networks lead to a better QoL, morbidity has a greater effect on the QoL among older adults in Nouna and hence, investing more on improving the physical and mental health needs appears more beneficial.

17.
arXiv (CS.LG) 2026-06-16

The Complexity of Min-Max Optimization for Quadratic Polynomials

arXiv:2606.17000v1 Announce Type: cross Abstract: We prove that computing approximate stationary points of min-max optimization over the hypercube is PPAD-hard for quadratic polynomials. This holds even when the polynomials are multilinear, each variable appears in at most three monomials, and the approximation factor is inverse polynomial. As a direct consequence, we obtain the first PPAD-hardness results for two-team zero-sum polymatrix games.

18.
arXiv (CS.AI) 2026-06-25

Hierarchical Reinforcement Learning for Neural Network Compression (HiReLC): Pruning and Quantization

arXiv:2606.26002v1 Announce Type: cross Abstract: We present HiReLC, a hierarchical ensemble-reinforcement learning framework for automated joint quantization and structured pruning of deep neural networks. The framework decomposes the compression search across two levels of abstraction: low-level agents (LLAs) operate independently per block, selecting per-kernel configurations over a multi-discrete action space spanning bitwidth, pruning keep-ratio, quantization type, and granularity, while high-level agents (HLAs) coordinate global budget allocation via ensemble voting guided by Fisher Information-based sensitivity estimates. To mitigate the computational cost of policy evaluation, an iterative active learning loop interleaves surrogate-guided RL optimization with post-compression fine-tuning, using a lightweight MLP surrogate to amortize expensive evaluations and a logit-MSE proxy during cold-start. The surrogate is used for reward shaping rather than as a replacement for final post-compression evaluation. The controller is architecture-agnostic by design, with a modular layer abstraction decoupling the RL environment from the underlying network topology. Experiments across Vision Transformer and CNN benchmarks demonstrate effective parameter-storage compression ratios of 5.99 - 6.72$\times$ with a 3.83 % gain in one setting and 0.55 - 5.62 % accuracy drops elsewhere, supporting hierarchical policy decomposition and sensitivity-aware guidance as practical design choices for joint neural network compression.

19.
arXiv (math.PR) 2026-06-25

Itô's Formula for It\^{o} processes defined with respect to a cylindrical-martingale valued measure

arXiv:2407.16086v3 Announce Type: replace Abstract: Using the authors' recently developed stochastic integration [Stoch PDE: Anal Comp, 2024], we prove an It\^{o} formula for Hilbert space-valued It\^{o} processes defined with respect to a cylindrical martingale-valued measure. We develop some tools from stochastic analysis, as are the predictable and optional quadratic variation of a stochastic integral, the continuous and purely discontinuous parts of an integral process, and a Riemann representation formula. As an application of our It\^{o} formula, we prove a Burkholder inequality for the stochastic integral defined with respect to a cylindrical martingale-valued measure. Finally, we derive It\^{o} formulas for Hilbert space-valued martingale-valued measures and for cylindrical square integrable martingales.

20.
arXiv (CS.LG) 2026-06-18

Sequential Hiring of Contingent Workers Through Learning-Based Optimization

arXiv:2606.18438v1 Announce Type: cross Abstract: In this paper, we study a sequential workforce management problem in a contingent labor setting with uncertainty in both worker production and labor supply. A firm seeks to maximize cumulative profit by maintaining an active team of fixed size while learning worker productivity over time. We emphasize two critical operational frictions in this problem: replacing workers is costly, and workers may not be available immediately for hiring because of, for example, prior job commitments, scheduling constraints, or onboarding procedures. Thus, hiring decisions take effect only after a random delay. We formulate this problem as a stochastic multi-play bandit with costly switching and delayed actions, and develop a learning-based hiring policy, DR-UCB (DelayedReplacement-UCB), that makes replacement and hiring decisions sequentially through learning cycles. In each cycle, the policy uses real-time production data to determine when to initiate workforce changes and which workers to replace and hire. We show that the leading-order regret of the proposed policy matches its lower bound in its dependence on the time horizon. Our numerical experiments show that DR-UCB outperforms benchmark policies.

21.
arXiv (CS.AI) 2026-06-11

Compiler-First State Space Duality and Portable $O(1)$ Autoregressive Caching for Inference

arXiv:2603.09555v2 Announce Type: replace-cross Abstract: High-throughput Mamba-2 inference is usually tied to fused CUDA and Triton kernels, limiting portability across accelerator backends. We show that the state space duality (SSD) recurrence has a compiler-friendly structure: diagonal per-head dynamics, fixed-size chunking, einsum-dominated compute, and static control flow. Expressing this structure in standard JAX primitives gives a single-source inference path with no custom kernels, a registered JAX PyTree cache, and a compiled on-device autoregressive loop. On a single Google Cloud TPU v6e, batch-1 prefill reaches approximately 140 TFLOPS, or 15% model FLOP utilisation (MFU), the roofline ceiling for this regime, and cached decode reaches up to 64% hardware bandwidth utilisation (HBU). At a 4096-token context, cached decode is 27x–36x faster than full-prefix recomputation across five Mamba-2 checkpoints from 130M to 2.7B parameters. The same source runs unmodified on NVIDIA L40S, where cached decode remains sequence-length independent across all model scales. WikiText-103 validation perplexity matches the Triton reference mamba_ssm v2.2.2 within +/-0.0005 points, and hidden states agree to float32 rounding tolerance. Code is available at https://github.com/CosmoNaught/mamba2-jax.

22.
arXiv (CS.AI) 2026-06-19

Modeling Day-Long ECG Signals to Predict Heart Failure Risk with Explainable AI

arXiv:2601.00014v2 Announce Type: replace-cross Abstract: Heart failure (HF) affects 11.8% of adults aged 65 and older, reducing quality of life and longevity. Preventing HF can reduce morbidity and mortality. We hypothesized that artificial intelligence (AI) applied to 24-hour single-lead electrocardiogram (ECG) data could predict the risk of HF within five years. To research this, the Technion-Leumit Holter ECG (TLHE) dataset, including 69,663 recordings from 47,729 patients, collected over 20 years was used. Our deep learning model, DeepHHF, trained on 24-hour ECG recordings, achieved an area under the receiver operating characteristic curve of 0.80 that outperformed a model using 30-second segments and a clinical score. High-risk individuals identified by DeepHHF had a two-fold chance of hospitalization or death incidents. Explainability analysis showed DeepHHF focused on arrhythmias and heart abnormalities. This study highlights the feasibility of deep learning to model 24-hour continuous ECG data, capturing paroxysmal events essential for reliable risk prediction. Artificial intelligence applied to single-lead Holter ECG is non-invasive, inexpensive, and widely accessible, making it a promising tool for HF risk prediction.

23.
arXiv (CS.CL) 2026-06-16

Do LLMs Reliably Identify Correct Information Units in Aphasic Discourse?

Correct Information Units (CIUs) are central to discourse assessment in aphasia because they quantify communicative informativeness rather than linguistic form alone. However, CIU scoring is time intensive and requires trained raters. This study examined whether instruction-tuned large language models (LLMs) can reliably perform token-level CIU classification from aphasic discourse transcripts. Sixteen picture-description transcripts elicited with the Cat Rescue stimulus were annotated for CIU status according to Nicholas and Brookshire (1993). The sample spanned four severity strata: control, mild, moderate, and severe aphasia. Four publicly available instruction-tuned LLMs were benchmarked under zero-shot and two few-shot prompting conditions across five stratified random seeds. Performance was evaluated against consensus human labels using accuracy, precision, recall, F1, and Cohen's kappa. Zero-shot prompting was insufficient across models. In contrast, few-shot prompting yielded substantial gains and produced competitive performance for three viable models. Mean few-shot F1 scores ranged from 0.776 to 0.817 across Llama-3.1-8B, Qwen2.5-7B, and Mistral-7B, with no significant differences between fixed global and per-chunk local example selection. Phi-3-mini was unstable and did not yield reliable performance. Viable models showed high recall but lower precision, suggesting systematic over-classification of tokens as CIUs. Performance also varied by discourse severity, with the weakest results in more severe aphasia. Few-shot LLM prompting can support automated CIU identification without gradient-based task training, but agreement with human annotation remains insufficient for fully autonomous use. These findings support LLM-based CIU scoring as a promising human-in-the-loop component of discourse assessment systems.

24.
arXiv (CS.CV) 2026-06-16

LentiAvatar: Pseudo-Multiview Reconstruction and Subpixel Prism Rendering for Real-Time Stereoscopic Communication

Real-time stereoscopic video communication has long been a goal of immersive telepresence, yet practical systems still require specialized capture rigs or reduce remote users to a single portrait view. We present LentiAvatar, a Gaussian head-avatar system that connects monocular avatar capture with subpixel-encoded glasses-free lenticular display for real-time autostereoscopic communication. From a monocular portrait video, LentiAvatar reconstructs a controllable head avatar and optimizes it for the lateral viewing zones induced by the display. The method uses natural head turns as pseudo-multiview (PMV) supervision to constrain regions that are otherwise weakly observed in monocular training, including hair, ears, jaw contours, and neck boundaries. Reliable side frames are yaw-binned, aligned to virtual cameras, and supervised within a strict head-and-hair domain; contour-aware losses and staged regularization further suppress ghosting, alpha leakage, and depth instability while preserving lateral detail. At runtime, LentiAvatar renders 32 virtual views and encodes them into a 4K lenticular raster with calibrated subpixel-routing masks. The live-tracker prototype sustains 10.65 FPS, and a subject-specific distilled driver raises the same display pipeline to 38.49 FPS.

25.
medRxiv (Medicine) 2026-06-12

The Clinical Characteristics and mortality outcomes of Atrial fibrillation complicating Heart failure with reduced ejection fraction: A prospective study from South Africa

Background: A growing burden of cardiovascular risk factors has raised cardiovascular disease-related mortality in Sub-Saharan Africa (SSA), driving higher prevalence of heart failure with reduced ejection fraction (HFrEF) and its complication with atrial fibrillation (AF). No prospective study has examined AF's clinical impact on HFrEF in SSA. Aim: To determine AF prevalence in HFrEF, describe HFrEF-AF clinical characteristics, and determine AF's impact on mortality. Methods: In this prospective observational study at a tertiary hospital in Johannesburg, 136 HFrEF patients were enrolled and categorised as HFrEF- SR (sinus rhythm) or HFrEF-AF. Baseline clinical characteristics and biochemistry were recorded. Comprehensive echocardiography including left atrial strain by 2D speckle-tracking was performed. Median follow-up was 30.6 months. Results: AF was present in 28 patients (21%). The mean age was 58.7 {+/-} 14.9 years (52.9% male) and differed between groups (p < 0.001). Hypertensive heart disease was the leading cause of HFrEF (36%). Compared with SR, HFrEF-AF patients had poorer health status (KCCQ 27 [16-43] vs 45 [32-60], p < 0.001) and lower left atrial strain (26.2 {+/-} 11.3%, p < 0.001). Guideline-directed medical therapy was suboptimal in the AF group: anticoagulation use was higher than SR (60% vs 9.5%, p < 0.001) but overall inadequate; HFrEF-AF patients received lower median doses of carvedilol (15.6 mg vs 25 mg, p = 0.002) and enalapril (10 mg vs 20 mg, p = 0.004), and fewer received spironolactone (50% vs 75.3%, p = 0.013). Survival was significantly lower in HFrEF-AF (0.41 [0.22-0.61]) versus SR (0.73 [0.61-0.82], p < 0.001). Independent predictors of mortality included prior stroke, lower TAPSE and KCCQ, and higher E/e' and heart rate. Conclusion: AF is common among HFrEF patients in this SSA cohort (though lower than in high-income countries) and associates with worse clinical status, suboptimal therapy, and higher mortality.