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01.
medRxiv (Medicine) 2026-06-18

Distinct Neuronal, Proliferative, and Secretory Pathways are Perturbed in Cancer Survivors with Depressive Symptoms

Authors:
Trudeau↗Thati↗Ng↗D. Q↗Chavez-Iglesias↗Olshen↗A. B↗Dhruva↗Chan↗J. W↗R. J↗Kober↗…

Introduction Depression is highly prevalent among cancer survivors and may be biologically distinct, although clinical studies investigating these mechanisms remain limited. Thus, the aims of this study were to (1) identify perturbed biological pathways associated with depressive symptom severity in cancer survivors, and (2) investigate whether these pathways are common or distinct to those perturbed in an age-matched non-cancer cohort. Methods We analyzed cross-sectional self-reported and transcriptomic data from the Multi-Ethnic Study of Atherosclerosis (PHD #39341). Cancer survivors and an age-matched non-cancer cohort (target ratio 1:2) were identified. The 20-item Center for Epidemiologic Studies Depression Scale (CES-D) was used to split participants into low (CES-D

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02.
arXiv (quant-ph) 2026-06-16

Stronger Entanglement Dies Faster: Quantum Mpemba Effect in Dissipative Qubits

Authors:
Zhilong Liu↗Zehua Tian↗Jieci Wang↗

arXiv:2605.23197v3 Announce Type: replace Abstract: In classical thermodynamics, the Mpemba effect refers to the counterintuitive observation that hot water can freeze faster than cold water, manifesting as an anomalous crossing of dynamical trajectories. While analogues of this phenomenon have been explored in open quantum systems and spin-chain entanglement asymmetry, its connection to the finite-time decoupling of quantum correlations remains elusive. In this work, we report a distinct Mpemba effect for quantum entanglement in a dissipative quantum system associated with entanglement sudden death (ESD). By analyzing two qubits interacting with local amplitude damping reservoirs, we demonstrate that a more strongly entangled initial state can experience a faster collapse into a separable state than a more weakly entangled state. This anomalous decay stems from the competition between initial coherence and excited-state population, where the latter acts as a catalyst for ESD. We provide exact analytical derivations for the trajectory crossover and ESD time, and map the phase diagram to precisely identify the parameter regime where the effect occurs. Our results offer a new strategy for controlling the lifetime of quantum resources in dissipative environments.

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03.
arXiv (CS.CV) 2026-06-15

QualiaNet: An Experience-Before-Inference Network

Authors:
Paul Linton↗

Human 3D vision involves two distinct stages: an Experience Module, where stereo depth is extracted relative to fixation, and an Inference Module, where this experience is interpreted to estimate 3D scene properties. Paradoxically, although stereo vision does not provide us with absolute distance information, it nonetheless affects our inferences about distance. We propose the Inference Module exploits a natural scene statistic: near scenes produce vivid disparity gradients, while far scenes appear comparatively flat. QualiaNet implements this two-stage architecture computationally: disparity maps simulating human stereo experience are passed to a CNN trained to estimate distance. The network can recover distance from disparity gradients alone, validating this approach.

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04.
arXiv (CS.LG) 2026-06-12

Viral Proteins Reveal Geometry of Protein Language Models

Authors:
Arthur Bigot↗Harmon Bhasin↗Core Francisco Park↗Eugene Shakhnovich↗Dianzhuo Wang↗

arXiv:2606.12609v1 Announce Type: new Abstract: Protein language models are trained on highly imbalanced datasets, raising the question of how they represent underrepresented biological sequences. Using viral proteins as a case study across ESM model families, we identify a dominant nativeness axis in embedding space, aligned with masked reconstruction perplexity, that orders sequences from well-modeled cellular proteins through viral proteins to shuffled and random sequences. Scaling contracts this axis unevenly across viral families. Despite this, protein language model embeddings retain viral-specific signal: viral proteins remain linearly separable beyond zero-shot perplexity and shallow sequence features. Together, these results suggest that pLM representations are structured by a general notion of nativeness while preserving information specific to distinct biological groups.

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05.
bioRxiv (Bioinfo) 2026-06-21

DeepCDS: Ab initio coding sequence prediction in prokaryotic short reads

Authors:
Nielsen↗L. S↗Winther↗

Accurate coding sequence prediction in short prokaryotic metagenomic reads remains challenging due to sequence fragmentation, unknown sequence origins, and sequencing errors. Here we introduce DeepCDS, a deep learning-based ab initio coding sequence predictor trained on short prokaryotic sequences with and without simulated Illumina-like sequencing errors. DeepCDS integrates ESM-2 protein language model embeddings with nucleotide-level information to predict complete and fragmented coding sequence regions. Benchmarking on 215 phylogenetically diverse prokaryotic organisms demonstrates that DeepCDS consistently outperforms current state-of-the-art methods in coding sequence detection, start and stop codon localization, and robustness to different sequencing error profiles, while remaining operational at shorter sequence lengths than existing tools support. These findings demonstrate that protein language models capture distinct signals relevant for nucleotide-level coding sequence detection, especially at very short lengths. Ultimately, DeepCDS may help uncover the functional potential of the vast microbial diversity that remains genomically uncharacterized.

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06.
arXiv (CS.AI) 2026-06-16

SMEPilot: Characterizing and Optimizing LLM Inference with Scalable Matrix Extensions

Authors:
Feiyang Chen↗Haibo Chen↗

arXiv:2606.16332v1 Announce Type: cross Abstract: Modern CPUs increasingly integrate matrix extensions, such as Arm Scalable Matrix Extension (SME), that provide high-throughput matrix execution within the CPU. For LLM inference, however, these units are not a universal replacement for conventional CPU cores: prefill, decode, attention, and KV-cache operations expose different arithmetic intensities, vector behavior, and layout requirements, while SME units and CPU cores still compete for shared memory bandwidth. This paper studies this mismatch through a roofline-based characterization of SME-enabled CPUs and uses the resulting model to guide operator-level execution choices. We present SMEPilot, an LLM inference engine that selects CPU-only, SME-only, or cooperative SME+CPU execution for each operator shape. SMEPilot partitions matrix work across SME and CPU cores at tile granularity, overlaps SME-suitable matrix stages with CPU-suitable vector stages in attention, and maintains layout state so packed tensor representations are reused rather than repeatedly rebuilt on critical paths. Across Llama-3.2-3B, Qwen3-4B, and Qwen3-30BA3B on phone, PC, and server platforms, SMEPilot improves end-to-end inference performance by up to 3.94$\times$.

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07.
arXiv (CS.CV) 2026-06-16

ReportQA: QA-Based Radiology Report Evaluation

Authors:
Yiming Shi↗Shaoshuai Yang↗Xi Chen↗Haolin Li↗Hengyu Zhang↗Che Jiang↗Kaiwen Wang↗Xun Zhu↗Dong Xie↗Fei Wang↗Dejing Dou↗Miao Li↗…

Radiology report evaluation is essential for advancing automated report generation. Natural language generation metrics have limited clinical relevance. Clinical efficacy (CE) metrics evaluate important medical findings, but focus mainly on presence and cover only a limited set of entities. Due to heavy reliance on manual annotations, it is difficult for CE metrics to extend clinical entities or attributes. In clinical practice, radiology reports serve as a medium for information transfer. Clinicians use them to perform downstream diagnostic tasks without directly inspecting images. Based on this insight, we propose ReportQA, a clinical-related and flexible radiology report evaluation framework, supporting detailed quantitative analysis of radiology report generation systems. We first collect datasets covering multiple imaging modalities and anatomical regions. We then construct knowledge trees of clinical entities and attributes with radiologist guidance, and use large language models (LLMs) to extract structured information from raw reports. Next, we generate QA pairs from predefined templates and apply quality control through self-filtering and report-based filtering. During evaluation, the report is treated as context, and an LLM acts as a judge model to answer the QA pairs. Based on the resulting QA accuracy, we introduce QAScore metric. Compared with existing metrics, QAScore shows better alignment with radiologist judgments. Experiments on multiple state-of-the-art vision-language models reveal that current report-based inference paradigms struggle to learn fine-grained clinical representations and exhibit strong negative prior biases. In contrast, question-driven inference provides a more effective alternative. For reproducibility and extensibility, we release the knowledge trees, structured reports, and QA pairs, along with the pipeline code for QA construction and evaluation.

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08.
arXiv (CS.AI) 2026-06-16

The Missing Knowledge Layer in Cognitive Architectures for AI Agents

Authors:
Micha\"el Roynard↗

arXiv:2604.11364v2 Announce Type: replace Abstract: The two most influential cognitive architecture frameworks for AI agents, CoALA [21] and JEPA [12], both lack an explicit Knowledge layer with its own persistence semantics. This gap produces a category error: systems apply cognitive decay to factual claims, or treat facts and experiences with identical update mechanics. We survey persistence semantics across existing memory systems and identify eight convergence points, from Karpathy's LLM Knowledge Base [10] to the BEAM benchmark's near-zero contradiction-resolution scores [22], all pointing to related architectural gaps. We propose a four-layer decom position (Knowledge, Memory, Wisdom, Intelligence) where each layer has fundamentally different persistence semantics: indefinite supersession, Ebbinghaus decay, evidence-gated revision, and ephemeral inference respectively. Companion implementations in Python and Rust demonstrate the architectural separation is feasible. We borrow terminology from cognitive science as a useful analogy (the Knowledge/Memory distinction echoes Tulving's trichotomy), but our layers are engineering constructs justified by persistence-semantics requirements, not by neural architecture. We argue that these distinctions demand distinct persistence semantics in engineering implementations, and that no current framework or system provides this.

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09.
arXiv (quant-ph) 2026-06-12

Exploring Exotic Spin-Dependent Interactions Beyond the Standard Model: Theoretical Foundations and Experimental Investigations

Authors:
L. Y. Wu↗H. Yan↗

arXiv:2606.13318v1 Announce Type: cross Abstract: New interactions mediated by novel particles propose solutions to several important questions in modern physics. Axions serve as examples of such particles; they are lightweight and interact weakly with ordinary matter. This category of particles, including those similar to axions-termed Axion-Like Particles (ALPs)-arises from diverse theoretical frameworks, such as the Peccei-Quinn mechanism addressing the strong CP problem, string theory, and spontaneous supersymmetry breaking. Given their light mass and weak coupling, ALPs are also possible candidates for cold dark matter. Introducing these new interactions mediated by novel particles not only tackles several challenges in modern physics but also raises a crucial question: Are there undiscovered interactions beyond the Standard Model? Many of the interactions predicted by these theories are spin-dependent, which is the primary focus of this review. In this review, we first outline the theoretical foundations for investigating exotic spin-dependent interactions, highlighting their importance in various models beyond the Standard Model. We examine the potential roles of new lightweight particles in mediating these interactions, which may enhance our understanding of dark matter. Relevant formulas derived from theoretical models are included to support experimental investigations. Following this theoretical framework, we conduct a detailed review of recent experimental efforts to detect these exotic interactions. A systematic review of current constraints on these interactions is presented, along with an assessment of various detection approaches.

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10.
arXiv (quant-ph) 2026-06-25

Reading Weakly, Acting Strongly: A Static Parity Horizon and its Dynamical Bypass in the Monitored Lipkin-Meshkov-Glick Model

Authors:
Stavros Mouslopoulos↗

arXiv:2606.24928v1 Announce Type: new Abstract: We study the broken-symmetry phase of the Lipkin-Meshkov-Glick (LMG) model, whose two lowest states form a near-degenerate parity doublet split by tunnelling. We show that the same instanton action S_inst that sets the doublet splitting also controls how much parity information a static J_z magnetisation readout can extract. Although J_z measures magnetisation rather than parity - and so distinguishes the two wells easily while remaining almost blind to their relative sign - WKB barrier arguments together with exact diagonalisation show that the spectral gap, the total-variation distance, and the nonlinear distinguishability measures (Jensen-Shannon divergence and Chernoff information) share a single instanton exponent, rather than the doubled exponent a naive small-deviation expansion in the lobes would suggest. Exact diagonalisation up to N = 4500 supports a common leading exponent for all four quantities, with fitted values within a few percent of the WKB instanton value in the largest reliable windows. The same coupling acts strongly inside the doublet: its off-diagonal element grows as |J_01| -> N m_*/2, so the bath can disturb the parity label far more strongly than it can read it from a frozen histogram. We call this separation the static parity horizon - a benchmark for the idealised static J_z channel, not a universal bound on time-resolved monitoring. Restoring the full monitored dynamics, continuous-monitoring simulations (1.48 million full-LMG trajectories with matched QND controls across 77 independent settings) show that a time-resolved homodyne record extracts parity information hidden from the single-shot histogram, over a finite window of system sizes organised by the ratio xi = omega_01/Gamma_01 of coherent doublet rotation to measurement-induced dephasing, and closing again under strong measurement.

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11.
arXiv (CS.LG) 2026-06-18

Model-Free Reinforcement Learning Control for Resilient Cyber-Physical Systems

Authors:
Hugo O. Garc\'es↗Alejandro J. Rojas↗Bernardo A. Hern\'andez↗Andr\'es Escalona↗Jonathan M. Palma↗Md. Rezwan Parvez↗Bhushan Gopaluni↗Sirish L. Shah↗

arXiv:2606.19069v1 Announce Type: cross Abstract: This paper compares the performance of model-free controllers on a nonlinear system under cyberattacks, including false data injection and denial-of-service attacks. Four RL reward types are analyzed for accuracy, cost, and resilience. Results show that the Lyapunov reward offers the best resilience with low tracking error. Exponential mode also provides good trade-offs with acceptable resilience under moderate training conditions. Progressive and linear rewards converge faster but are less robust. RL-MPCs show strong steady-state resilience but require longer training times; RL-PID controllers are faster with significantly less training time. Proximal Policy Optimization outperforms Deep Deterministic Policy Gradient with a significant reduction in KPI variance. This study serves to highlight how well-designed RL rewards can improve performance and resilience against cyber threats.

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12.
arXiv (CS.LG) 2026-06-15

Shuttling Compiler for Trapped-Ion Quantum Computers Based on Large Language Models

Authors:
Fabian Kreppel↗Reza Salkhordeh↗Ferdinand Schmidt-Kaler↗Andr\'e Brinkmann↗

arXiv:2512.18021v3 Announce Type: replace-cross Abstract: We present the first shuttling compiler based on large language models (LLMs) for trapped-ion quantum computers, where qubits are shuttled between segments for gate execution and qubit storage. We fine-tune pre-trained LLMs on examples from linear and branched one-dimensional shuttling architectures. Thus, we obtain a layout-independent compilation strategy that learns the required shuttling operations directly from data. Using benchmark circuits with up to 16 qubits, such fine-tuned LLMs can now generate valid schedules for shuttling architectures. Notably, we also obtain a valid schedule for a previously unseen four-way junction layout. This demonstrates that trained LLMs can generalize to layouts not encountered during training. For various architectures, LLM-based schedules improve upon state-of-the-art baseline compiler results, reducing the shuttling effort by up to 15%.

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13.
arXiv (CS.CL) 2026-06-24

When Retrieval Metrics Mislead: Measuring Policy Signal in Long-Horizon Tool-Use Agents

Authors:
Tianyu Ding↗Juan Pablo De la Cruz Weinstein↗

Exact-match retrieval recall is often used as a proxy for whether a retriever supplies useful policy context to a downstream decision model. We test this proxy for pre-action policy classification in tau-bench using Qwen2.5-3B/7B classifiers. Under gold-policy conditioning, a compact structured state improves macro-F1 over raw trajectories by 0.13-0.17 after tuning. We then replace the benchmark-designated policy clause with the top-ranked clause retrieved from decision-time context. Although the exact governing clause is retrieved at rank 1 for only 7% of airline states, the primary 3B classifier obtains macro-F1 0.58 with retrieved clauses versus 0.60 with gold clauses (Delta=-0.02, task-cluster 95% CI [-0.23,+0.21]); mismatched-policy and no-policy controls score 0.32 and 0.21. We do not detect a macro-F1 difference between retrieved and gold clauses in this configuration, although the interval remains too wide to establish non-inferiority. The same qualitative pattern appears with a second retriever and at 7B, while varying across fine-tuning configurations. These results indicate that exact-match clause recall can underestimate downstream policy utility in this benchmark setting, motivating evaluation with retrieved policies in the classification loop rather than recall alone.

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14.
arXiv (math.PR) 2026-06-16

Stein's method for the matrix normal distribution

Authors:
Robert E. Gaunt↗Fr\'ed\'eric Ouimet↗Donald Richards↗

arXiv:2601.11422v2 Announce Type: replace-cross Abstract: This work presents the first systematic development of Stein's method for matrix distributions. We establish the basic essential ingredients of Stein's method for matrix normal approximation: we derive an extended-generator-based Stein identity from a matrix Ornstein-Uhlenbeck diffusion with two-sided scales, provide an explicit semigroup representation for the solution of the Stein equation, and obtain regularity estimates for the solution. The new methodology is demonstrated in three examples: (i) smooth Wasserstein distance bounds to quantify the matrix central limit theorem (a didactic example), (ii) a Wasserstein distance bound for the matrix normal approximation of the centered matrix $T$ distribution, and (iii) a Stein's method-of-moments approach to estimating the row and column covariance factors of the matrix normal, yielding a flexible class of weighted flip-flop Stein estimators that generalize Dutilleul's classical flip-flop algorithm and naturally accommodate row/column importance weights, systematic missingness, and projection onto structured covariance families. The latter two examples are intrinsically matrix-valued and cannot be treated using naive vectorization.

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15.
arXiv (CS.CL) 2026-06-24

Preferences of a Voice-First Nation: Large-Scale Pairwise Evaluation and Preference Analysis for TTS in Indian Languages

Authors:
Srija Anand↗Ashwin Sankar↗Ishvinder Sethi↗Aaditya Pareek↗Kartik Rajput↗Gaurav Yadav↗Nikhil Narasimhan↗Adish Pandya↗Deepon Halder↗Mohammed Safi Ur Rahman Khan↗Praveen S V↗Shobhit Banga↗…

Crowdsourced pairwise evaluation has emerged as a scalable approach for assessing foundation models. However, applying it to Text to Speech(TTS) introduces high variance due to linguistic diversity and multidimensional nature of speech perception. We present a controlled multidimensional pairwise evaluation framework for multilingual TTS that combines linguistic control with perceptually grounded annotation. Using 5K+ native and code-mixed sentences across 10 Indic languages, we evaluate 7 state-of-the-art TTS systems and collect over 120K pairwise comparisons from over 1900 native raters. In addition to overall preference, raters provide judgments across 6 perceptual dimensions: intelligibility, expressiveness, voice quality, liveliness, noise, and hallucinations. Using Bradley-Terry modeling, we construct a multilingual leaderboard, interpret human preference using SHAP analysis and analyze leaderboard reliability alongside model strengths and trade-offs across perceptual dimensions.

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16.
arXiv (quant-ph) 2026-06-25

From Rubble Simulation to Active Magnetic Mapping: Quantum Sensing for Disaster Response

Authors:
Samuel Tovey↗Stefan Prestel↗Hiroshi Yamauchi↗

arXiv:2606.25957v1 Announce Type: cross Abstract: Locating survivors of building collapses within the first 72 hours is a critical challenge in disaster response, and existing sensing modalities provide only partial information about the structure beneath the rubble. This paper proposes drone-based quantum magnetometry as a complementary modality and develops a simulation pipeline spanning rubble physics, sensor-array deployment, and active spatial reconstruction. We use Unreal Engine to generate a steel-reinforced concrete parking-garage collapse and compute the induced magnetic field via a per-triangle dipole approximation, establishing that meaningful magnetic structure is recoverable in the sub-pT to sub-nT range from roughly 1 m above the roofline. Then, we feed sparse multi-sensor samples into a Gaussian Process Regression back-end driven by Bayesian active sampling and validate the pipeline across multiple independent collapse realizations; a three-sensor array optimizes the trade-off between gradient resolution and UAV payload constraints, and active sampling reaches peak structural correlation in roughly $100$ samples. Together, these results indicate that quantum-grade sensing could become a useful tool for drone-based structural analysis and potentially void detection in collapsed buildings.

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17.
Nature (Science) 2026-06-10

Whole-genome duplication shaped cell-type evolution in the vertebrate brain

Authors:
Yuanzhen Zhu↗

The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show one-to-one homology with amphioxus. Moreover, ohnologues, particularly those from the first WGD, were more important than small-scale duplication paralogues for vertebrate cell-type evolution. To explore whether ohnologues are mechanistically important for this process, we predicted ancestral cell-type states and compared them to amphioxus and experimentally investigated macroglia. The findings indicate that ohnologues had a role in early vertebrate cell-type diversification. Moreover, by examining paralogue expression across cell types and species, we show that expression changes were mainly driven by dosage selection and subfunctionalization. We also link ohnologues to cellular diversity at different anatomical and cell-type scales. Our findings demonstrate the importance of WGDs for the evolution of early vertebrate brain complexity and highlight that the resultant ohnologues continued to capacitate cell-type evolution long after they were formed. Analyses of brain single-cell transcriptomes from human, mouse, lizard, lamprey and amphioxus reveal that duplicated genes (ohnologues) played a pivotal part in early vertebrate cell-type diversification.

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18.
arXiv (CS.CL) 2026-06-16

Bridging the Usability Gap: Lessons from Interpreting Studies for Machine Interpreting Design

Authors:
Claudio Fantinuoli↗

Machine interpreting (MI), the live, real-time branch of speech translation, has achieved remarkable progress on standard benchmarks, with some systems approaching human parity on textual fidelity. Yet the user experience remains far inferior to interpreter-mediated communication, revealing what we term the accuracy illusion: systems that appear accurate on paper but fail in practice to support smooth, goal-oriented interaction. This paper defines MI as a distinct subfield of speech translation, with its own characteristics and the need for evaluation methods grounded in communicative effectiveness rather than isolated fidelity metrics. Drawing on insights from interpreting studies, we identify critical dimensions of professional interpreting practice that are overlooked by current systems, and consolidate them into three interdependent design priorities for future MI: agency (context-sensitive initiative and repair), grounding (multimodal and discourse-level situational awareness), and experience (adaptive improvement through real interaction). Together, these priorities chart a path toward closing the usability gap and enabling systems that can sustain authentic multilingual communication in real time.

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19.
arXiv (CS.AI) 2026-06-18

NeSyCat Torch: A Differentiable Tensor Implementation of Categorical Semantics for Neurosymbolic Learning

Authors:
Daniel Romero Schellhorn↗Till Mossakowski↗Bj\"orn Gehrke↗

arXiv:2606.19279v1 Announce Type: new Abstract: Neurosymbolic semantics is fragmented: classical, fuzzy, probabilistic and neural systems each define truth by their own inductive rules. NeSyCat, extending ULLER, subsumes them under a single inductive definition of truth, parametric in a strong monad and an aggregation structure on truth-values. NeSyCat has so far lacked an account of predicates and functions learned by neural networks. We provide NeSyCat Torch as the missing link and interpret computational symbols via neural networks, implementing the framework in probabilistic programming and tensor-based backends. We use the distribution monad for reference semantics and metric evaluation, and complement it by a monad for numerically stable, differentiable training: the lazy log-tensor monad over the log-semiring. For efficient training in batches, we furthermore employ a batch monad. The axioms are the source code: written once in monad-based do-notation, monadic bind performs marginalisation, lazily pruning unneeded branches. On MNIST addition, our HaskTorch, JAX, and PyTorch implementations outperform LTN and DeepProbLog in speed and accuracy, while achieving nearly the accuracy of DeepStochLog. However, unlike DeepStochLog, we stay in a uniform framework that applies to many first-order NeSy approaches. Namely, the construction is parametric in the monad; instantiating it with, e.g., the Giry monad extends the approach to continuous probability (working out a neural representation here is left for future work).

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20.
medRxiv (Medicine) 2026-06-16

Exercise Training Improves Skeletal Muscle Insulin Sensitivity and Reprograms the Adipose Transcriptome in Heavier Monozygotic Twins

Authors:
Hentila↗Ullrich↗Ojala↗Lietzen↗M. S↗Heiskanen↗M. A↗Van der Stede↗Honkala↗Helmio↗Rajander↗Eskola↗…

Exercise training improves skeletal muscle insulin sensitivity, yet its effects on white adipose tissue remain incompletely understood. We investigated how adiposity and exercise training influence insulin-stimulated glucose uptake in skeletal muscle and abdominal subcutaneous adipose tissue (ASAT), alongside adaptations in gene expression and DNA-methylation. Ten monozygotic twin pairs discordant for BMI underwent [18F]FDG-PET/CT imaging of skeletal muscle (vastus lateralis, VL) and ASAT during a euglycemic-hyperinsulinaemic clamp before and after six months of exercise training. VL and ASAT biopsies were analyzed using mRNA-sequencing and reduced representation bisulfite sequencing. Exercise training improved whole-body and VL insulin sensitivity in leaner and heavier co-twins (p

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21.
arXiv (CS.CL) 2026-06-11

Hey Chat, Can You Teach Me? Structuring Socratic Dialogue for Human Learning in the Wild

Authors:
Sidney Tio↗Arunesh Sinha↗Pradeep Varakantham↗

Large language models are now widely used for everyday learning, but the underlying interactions are typically unstructured chats rather than following a curriculum. Unlike formal online learning systems, these interactions carry no prior record of the student, so any estimate of what the student already knows must be inferred from the dialogue itself. We show that this gap is not closed by scaling models alone. Frontier and education-tuned LLMs perform poorly when asked to tutor a student over an extended session, because doing so requires three things at once. The tutor must sequence a curriculum, conduct Socratic dialogue, and infer the student's knowledge state from that dialogue. We propose separating these responsibilities. Given a student query, our system constructs a prerequisite knowledge graph in which subtopics are nodes and dependencies are edges, and frames tutoring as deciding which node to teach next and how many dialogue turns to spend on it before moving on. A lightweight PPO policy handles this sequencing decision, while an LLM conducts the Socratic exchange at the chosen node and returns a signal of student progress. Across held-out STEM and non-STEM topics, our PPO-paired tutor outperforms heuristic baselines, frontier general-purpose models, and a model specialised for Socratic dialogue: on both the rate at which students reach full curriculum mastery and the number of turns required. Explicit curriculum structure delivers gains that scaling the underlying model does not.

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22.
arXiv (CS.CV) 2026-06-11

From Correspondence to Actions: Human-Like Multi-Image Spatial Reasoning in Multi-modal Large Language Models

Authors:
Masanari Oi↗Koki Maeda↗Ryuto Koike↗Daisuke Oba↗Nakamasa Inoue↗Naoaki Okazaki↗

While multimodal large language models (MLLMs) have made substantial progress in single-image spatial reasoning, multi-image spatial reasoning, which requires integration of information from multiple viewpoints, remains challenging. Cognitive studies suggest that humans address such tasks through two mechanisms: cross-view correspondence, which identifies regions across different views that correspond to the same physical locations, and stepwise viewpoint transformation, which composes relative viewpoint changes sequentially. However, existing studies incorporate these mechanisms only partially and often implicitly, without explicit supervision for both. We propose Human-Aware Training for Cross-view correspondence and viewpoint cHange (HATCH), a training framework with two complementary objectives: (1) Patch-Level Spatial Alignment, which encourages patch representations to align across views for spatially corresponding regions, and (2) Action-then-Answer Reasoning, which requires the model to generate explicit viewpoint transition actions before predicting the final answer. Experiments on three benchmarks demonstrate that HATCH consistently outperforms baselines of comparable size by a clear margin and achieves competitive results against much larger models, while preserving single-image reasoning capabilities.

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23.
medRxiv (Medicine) 2026-06-11

Foundation model-based tool for automated ulcerative colitis histology scoring demonstrates non-inferiority to pathologists across multiple scoring indices

Authors:
Tahir↗Shamshoian↗Tauber↗Clinton↗L. K↗Griffin↗Shah↗Singh↗Fahy↗Sucipto↗Brosnan-Cashman↗Altepeter↗…

In clinical trials for ulcerative colitis (UC), pathologists assess disease severity through standardized histological indices, including the Geboes Score, Robarts Histopathology Index (RHI), and Nancy Histologic Index (NHI). Despite strong associations with clinical outcomes, histologic scoring suffers from inter- and intra-reader variability, and consensus criteria for histologic remission remain uncertain. Through a consortium approach, we developed an artificial intelligence-based measurement (AIM) tool for scoring histology in UC mucosal biopsies (AIM-HI UC). This model, trained on a large dataset of UC biopsies (N=10,230), utilizes additive multiple instance learning models leveraging PLUTO, a pathology foundation model, that predict each of the Geboes subgrades, from which the Geboes grade-level score, RHI, and NHI can be calculated. Evaluation of this model on a standalone verification set including clinical trial specimens established algorithm non-inferiority and/or superiority relative to standard qualified pathologists through comparison of algorithm-consensus and pathologist-consensus agreement metrics (non-inferior if difference >-0.1, superior if difference >0, inclusive of confidence intervals). AIM-HI UC was determined to be non-inferior to pathologists (N=3) for the prediction of all seven Geboes subgrades, grade-level Geboes, RHI, NHI, histologic improvement (GS

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24.
arXiv (CS.LG) 2026-06-16

Empirical Study of Pop and Jazz Mix Ratios for Genre-Adaptive Chord Generation

Authors:
Jinju Lee↗

arXiv:2605.04998v2 Announce Type: replace-cross Abstract: This revision updates a pop-to-jazz chord-generation rehearsal study. Best-epoch metrics still show that modest pop rehearsal preserves pop accuracy while improving jazz prediction, but v2 corrects released-checkpoint selection: the released F1 equals Phase 0, F2 had a transcription error, and ft-pop80-v2 restores a hash-distinct jazz-adapted F1 across 3 seeds.

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25.
arXiv (CS.CL) 2026-06-25

Why Multi-Step Tool-Use Reinforcement Learning Collapses and How Supervisory Signals Fix It

Authors:
Yupu Hao↗Zhuoran Jin↗Huanxuan Liao↗Kang Liu↗Jun Zhao↗

Tool use enables large language models (LLMs) to perform complex tasks, and recent agentic reinforcement learning (RL) methods show promise for enhancing model capabilities. However, RL alone often leads to instability or limited gains in tool-use tasks. In our experiments, some models exhibit catastrophic collapse, where performance abruptly drops and tool-invocation structures fail. The analysis reveals that these failures stem from unexpected probability spikes in specific control tokens, disrupting structured execution, yet the underlying tool-use capability remains intact, merely obscured by specific formats. To address this, we systematically investigate a diverse set of supervisory signals, including off-policy supervision, hint-based guidance, erroneous example supervision, and others, applied under both synchronous and interleaved training schemes. We find that interleaving supervised fine-tuning (SFT) with RL substantially improves stability, but exhibits degraded performance under format and content out-of-distribution (OOD) evaluation. We also analyze the impact of learning rates and generalization across settings. These results highlight the importance of understanding RL failures and demonstrate how diverse supervisory signals can guide exploratory learning, enabling robust training of LLMs for complex, multi-step tool-use tasks. Our Code is available at https://github.com/hypasd-art/Tool-RL-Box.

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