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medRxiv (Medicine) 2026-06-16 DOI: HASH:f761cb028fc6d57c528a58d82118838e

Higher Population Coverage with Typhoid Conjugate Vaccine is Needed to Induce Herd Protection: Evidence from a Cluster-Randomized Trial in Urban Bangladesh

Authors:

Ahmmed ↗khanam ↗Islam ↗Park ↗S. E ↗Ongadi ↗Im ↗Zhang ↗Khan ↗A. I ↗Aziz ↗A. B ↗…

Introduction: A cluster randomized trial (CRT) in Bangladesh found that Vi-tetanus toxoid (Vi-TT) vaccine conferred 85% protection to vaccinees at 18 months of follow-up; however, it failed to confer significant herd protection to non-vaccinees. Methods: In the CRT, children aged 9 months to

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