Explore the Frontier of Global Academia

AcademicHub aggregates real-time literature from top journals and preprint platforms. Build your personal research radar and let large language models compile cross-disciplinary analysis briefings automatically.

Authors: Oksa ×

↻ Shuffle

01.

medRxiv (Medicine) 2026-06-22 DOI: HASH:cff11c4c4539678d82d6d8f31489239f

The circulating blood proteome of childhood acute leukemia

Authors:

Enblad ↗A. P ↗Globisch ↗M. A ↗Gogishvili ↗Tuononen ↗Krali ↗Lundmark ↗Oksa ↗Hjort ↗Lysenkova Wiklander ↗Holmfeldt ↗…

The circulating blood proteome provides a systemic readout of disease biology and holds promise for advancing diagnostics and disease monitoring in pediatric leukemia. Here, we profiled 3072 proteins in diagnostic serum from 54 children with acute lymphoblastic leukemia (ALL), 21 with acute myeloid leukemia (AML), and 12 healthy controls using the Olink Proximity Extension Assay. We observed profound alterations in circulating protein levels in leukemia patients compared with controls and identified immunophenotype-specific proteins, including SIGLEC15 in B-cell precursor ALL (BCP-ALL), NOTCH1 in T-ALL, and CEBPA in AML, all which remained high even in patients with low (

Read & Discuss → View Source →

02.

arXiv (CS.AI) 2026-06-17 DOI: arXiv:2606.10376

Belief-Space Control for Personalized Cancer Treatment via Active Inference

Authors:

Deniz Sargun ↗H. Bugra Tulay ↗C. Emre Koksal ↗

arXiv:2606.10376v2 Announce Type: replace Abstract: Cancer treatment is at the core a sequential decision-making problem with partial observability, latent patient heterogeneity, and explicit constraints on the budget for medical measurements. Unlike standard Reinforcement Learning (RL) approaches that control state trajectories, cancer treatments permanently modify patients' transition dynamics, changing how states evolve over time. We model cancer treatment as a belief-space planning problem using active inference, deriving an expected free-energy objective that unifies goal-directed control and information acquisition under measurement budgets without. We implement this framework using real clinical cancer data from the AACR Project GENIE Biopharma Collaborative dataset. Results on clinical data demonstrate a simultaneous patient categorization and high treatment efficacy, under real measurement and treatment constraints.

Read & Discuss → View Source →